Two Methods for the Treatment of Nonneoplastic Epithelial Disorders of Skin and Mucosa of Vulva Curative Effect Comparison

doi:10.3877/cma.j.issn.1673-5250.2013.06.024

Objective

To investigate the effect of ultrasonic therapy for nonneoplastic epithelial disorders of skin and mucosa of vulva (NEDV).

Methods

From January 2010 to January 2011,a total of 73 cases of NEDV patients were treated and randomly (according to numbers of treatment) divided into two groups:ultrasonic therapy group(n= 36), drug therapy group(n = 37). There were no significant difference in general clinical data between two groups (P>0. 05). Observe the clinical symptoms, signs and histological changes between two groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Beings of Nanjing Pukou District Center Hospital. Informed consent was obtained from each participating patient.

Results

The ultrasonic treatment group of 36 patients with vulva pruritus symptom disappeared basically, and epithelium lesions in different level back to normal, the cure and significant efficiency rate was 91. 7 %. Comparison of curative effect between different pathological type in the same group,the data has no significant difference (P>0. 05). There had significant difference between two groups in cure rate and significant efficiency rate (P<0. 05).

Conclusions

Curative effect of ultrasonic therapy for NEDV is obvious.

Key words: ultrasonic therapy, nonneoplastic epithelial disorders of skin and mucosa of vulva, drug therapy, women

表1 超声治疗后疗效分析[n(％)]

Table 1 Curative effects after ultrasonic treatment [n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	20	12(33.3)	6(16.7)	2(5.6)	0(0. 0)	1(2.8)
硬化苔癣型	16	11(30.6)	4(11.1)	1(2.8)	0(0. 0)	0(0.0)
合计	36	23(63.9)	10(27.8)	3(8.3)	0(0. 0)	1(2.8)
χ²	0. 467	0. 295	0. 111	0. 164	?	0. 823
P	0. 882	0. 731	1. 000	1. 000	?	1. 000

表1 超声治疗后疗效分析[n(％)]

Table 1 Curative effects after ultrasonic treatment [n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	20	12(33.3)	6(16.7)	2(5.6)	0(0. 0)	1(2.8)
硬化苔癣型	16	11(30.6)	4(11.1)	1(2.8)	0(0. 0)	0(0.0)
合计	36	23(63.9)	10(27.8)	3(8.3)	0(0. 0)	1(2.8)
χ²	0. 467	0. 295	0. 111	0. 164	?	0. 823
P	0. 882	0. 731	1. 000	1. 000	?	1. 000

表2 药物治疗后疗效分析[n(％)]

Table 2 Curative effects after drug therapy[n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	18	6(16.2)	6(16.2)	3 (8. 1)	3(8.1)	12(32. 4)
硬化苔癣型	19	5(13.5)	7(18.9)	4(10.8)	3(8.1)	13(35. 1)
合计	37	11(29.7)	13(35.1)	7(18.9)	6(16.2)	25(67. 6)
χ²	0. 508	0. 218	0. 050	0. 116	0. 005	0. 130
P	1. 000	0. 728	1. 000	1. 000	1. 000	1. 000

表2 药物治疗后疗效分析[n(％)]

Table 2 Curative effects after drug therapy[n(%)]

病理类型	n	治愈率	显效率	好转率	无效率	复发率
鳞状上皮增生型	18	6(16.2)	6(16.2)	3 (8. 1)	3(8.1)	12(32. 4)
硬化苔癣型	19	5(13.5)	7(18.9)	4(10.8)	3(8.1)	13(35. 1)
合计	37	11(29.7)	13(35.1)	7(18.9)	6(16.2)	25(67. 6)
χ²	0. 508	0. 218	0. 050	0. 116	0. 005	0. 130
P	1. 000	0. 728	1. 000	1. 000	1. 000	1. 000

表3 2组病人疗效比较[n(%)]

Table 3 Comparison of curative effects between two groups[n(%)]

组别	n	治愈及显效率	复发率
超声治疗组	36	33(91. 7)	1 (2.8)
药物治疗组	37	24(64. 9)	25(67.6)
χ²	?	7. 659	33. 402
P	?	0. 010	0. 000

表3 2组病人疗效比较[n(%)]

Table 3 Comparison of curative effects between two groups[n(%)]

组别	n	治愈及显效率	复发率
超声治疗组	36	33(91. 7)	1 (2.8)
药物治疗组	37	24(64. 9)	25(67.6)
χ²	?	7. 659	33. 402
P	?	0. 010	0. 000

1	Toyari Yoshi, Shen K. Obstetrics and Gynecology[M]. 2nd ed. Beijing: People's Medical Publishing House, 2011:306.
2	Liu BN. Pathological changes of white lesions of the vulva [J]. J Pract Obstet Gynecol, 2003,19:3-5.
3	Wang ZB. White lesions of the vulva by ultrasound treatment[J]. J Pract Obstet Gynecol, 2003,19(1) :6.
4	Pei LH. Focused ultrasound in the treatment of white lesions of the vulva:Clinical observation of 92 cases [J]. Binzhou Med Univ J, 2009,32 (5):385-386.
5	Wang DB. Focused ultrasound treatment technology in gynecologic field research and application[J]. Chin J Obstet Gynecol, 2006,41 (9):638-639.
6	Li CZ, Du YH, Cao YD, et al. Experimental study of high intensity focused ultrasound in the treatment of advanced vulvar neoplasms[J]. Chin J Ultrasound Med, 2002,18(7) :489-492.
7	Yin GP, Wu AF, Liang J, et al. Expression of survivin, estrogen and progesterone receptor in focal tissues before and after treatment by high intensity focused ultrasound for nonneoplasia epithelial disorders of skin and mucosa of vulva[J/CD]. Chin J Obstet Gynecol Pediatr: Electron Ed,2013,(05) : 589-593.
8	Yin GP, Ti SM, Yang SJ, et al. Therapeutic methods and effects of high intensity focused ultrasound on the treatment of nonneoplasia epithelial disorders of skin and mucosa of vulva [J/CD]. Chin J Obstet Gynecol Pediatr : Electron Ed, 2010,6(4) : 7-11.

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