Therapeutic Effects of Meglumine Adenosine Cyclophosphate Combined With Fructose l, 6-Diphosphate on Bronchiolitis Complicated With Myocardial Damage

doi:10.3877/cma.j.issn.1673-5250.2011.01.010

Objective

To investigate therapeutic effects of meglumin adenosine cyclophosphate (MAC) combined with fructose l, 6-diphosphate (FDP) in the treatment of bronchiolitis complicated with myocardial damage.

Methods

From January 2007 to June 2009, 235 children who were diagnosed as bronchiolitis complicated with myocardial damage were recruited into this study. They were randomly divided into two groups, treatment group (n=115) and control group (n=120). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Third People's Hospital of Jinan, Shandong Province. Informed consent was obtained from all participants. Two groups were received the routine treatment, then, treatment group were added meglumine adenosine cyclophosphate+ fructose l, 6-diphosphate, while control group were added energy mixture. The regression time of main clinical symptoms and change trend of myocardial enzymes were observed.

Results

The regression time of main clinical symptoms, recovery time of serum myocardial enzymes in treatment group were shorter than those of control group (P<0.01).

Conclusion

Therapeutic effects of meglumin adenosine cyclophosphate combined with fructose l, 6-diphosphate in the treatment of bronchiolitis complicated with myocardial damage is effective with no adverse reaction. But further study should be conducted to comfirm whether it is worthy of clinical application.

Key words: bronchiolitis, myocardial enzymes, myocardial damage, meglumine adenosine cyclophosphate (MAC), fructose l, 6-diphosphate (FDP)

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