Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (04): 483 -487. doi: 10.3877/cma.j.issn.1673-5250.2018.04.018

Special Issue:

Review

Research progress on prevention and treatment of wheezing in infants

Li Zhang1, Huifen Zi2,()   

  1. 1. Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014040, Inner Mongolia Autonomous Region, China; Department of Pediatrics, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China
    2. Department of Pediatrics, Baotou Central Hospital, Baotou 014040, Inner Mongolia Autonomous Region, China
  • Received:2018-03-19 Revised:2018-06-30 Published:2018-08-01
  • Corresponding author: Huifen Zi
  • About author:
    Corresponding author: Zi Huifen, Email:

Wheezing is one of the most common clinical manifestations of childhood respiratory diseases. The incidence of wheezing in infants has been obviously rising in recent years. The causes of wheezing in infants are mainly related to respiratory infection and specific constitution of infants, and wheezing is closely related to the attack of asthma, there is a certain correlation between them in the pathogenesis and risk factors. Although there is no precise method for screening wheezing infants who may develop into asthma, some reference indicators can be used for comprehensive assessment of wheezing infants and early intervention. The latest research advances in the etiology, pathogenesis, related factors, prevention, diagnosis and treatment of wheezing in infant are elaborated in order to provide a theoretical basis for reducing the onset of wheezing in infants and thus reducing the incidence of asthma.

[1]
Alvarez-Alvarez I, Niu H, Guillen-Grima F, et al. Meta-analysis of prevalence of wheezing and recurrent wheezing in infants[J]. Allergol Immunopathol (Madr), 2018, 46(3): 210-217.
[2]
魏琳,张玉娥,金惠娣,等. 反复喘息患儿1 035例随访分析[J]. 临床儿科杂志,2014, 32(6): 532-535.
[3]
钱胜华,张莉,王晓花,等. 5岁以下儿童反复喘息发作呼吸道病原分析[J]. 临床肺科杂志,2016, 21(12): 2249-2251.
[4]
Rossi GA, Colin AA. Infantile respiratory syncytial virus and human rhinovirus infections: respective role in inception and persistence of wheezing[J]. Eur Respir J, 2015, 45(3): 774-789.
[5]
Takeyama A, Hashimoto K, Sato M, et al. Clinical and epidemiologic factors related to subsequent wheezing after virus-induced lower respiratory tract infections in hospitalized pediatric patients younger than 3 years[J]. Eur J Pediatr, 2014, 173(7): 959-966.
[6]
Ding FX, Luo J, Fu Z. Research progress in the relationship between childhood wheezing and bacteria[J]. Chin J Contemp Pediatr, 2015, 17(5): 528-532.
[7]
赵志云. 儿童哮喘与肺炎支原体感染检验结果及相关性探讨[J]. 临床肺科杂志,2014, 19(8): 1497-1498.
[8]
Abrahamsson TR, Sandberg Abelius M, Forsberg A, et al. A Th1/Th2-associated chemokine imbalance during infancy in children developing eczema, wheeze and sensitization[J]. Clin Exp Allergy, 2011, 41(12): 1729-1739.
[9]
江霞辉,陆俏群,赵若雯. 毛细支气管炎与哮喘患儿T淋巴细胞亚群及干扰素-γ、白介素-4的对比分析[J]. 中国妇幼保健,2013, 28(23): 3784-3786.
[10]
毛国其,蒋文良. 小儿呼吸道合胞病毒毛细支气管炎血Th17/Treg失衡机制及意义[J]. 中国妇幼健康研究,2017, 28(12): 1734-1735.
[11]
Chkhaidze I, Zirakishvili D, Shavshvishvili N, et al. Prognostic value of TH1/TH2 cytokines in infants with wheezing in a three year follow-up study[J]. Pneumonol Alergol Pol, 2016, 84(3): 144-150.
[12]
Guilbert TW, Morgan WJ, Krawiec M, et al. The prevention of early asthma in kids study: design, rationale and methods for the childhood asthma research and education network[J]. Control Clin Trials, 2004, 25(3): 286-310.
[13]
赵德育. 婴幼儿喘息流行病学及发展趋势[J]. 中国实用儿科杂志,2014, 29(6): 401-404.
[14]
Amin P, Levin L, Epstein T, et al. Optimum predictors of childhood asthma: persistent wheeze or the asthma predictive index?[J]. J Allergy Clin Immunol Pract, 2014, 2(6): 709-715.
[15]
Burbank AJ, Szefler SJ. Current and future management of the young child with early onset wheezing[J]. Curr Opin Allergy Clin Immunol, 2017, 17(2): 146-152.
[16]
Price D, Ryan D, Burden A, et al. Using fractional exhaled nitric oxide (FeNO) to diagnose steroid-responsive disease and guide asthma management in routine care[J]. Clin Transl Allergy, 2013, 3(1): 37.
[17]
蔡青,邓金强. 婴幼儿喘息性疾病FeNO检测与sIgE、IgE的相关性分析[J]. 中国医药导报,2017, 14(12): 97-100.
[18]
王红,兰常肇,马少杰,等. 婴幼儿反复喘息与血清维生素D水平相关性研究[J]. 国际儿科学杂志,2014,7(4): 421-423.
[19]
孙秋凤,蒋吴君,陈正荣,等. 血清25-羟维生素D3水平与婴儿喘息关系及临床意义探讨[J]. 中国实用儿科杂志,2015, 30(3): 199-202.
[20]
徐艳娜,顾建华,李永莲,等. 反复喘息婴幼儿维生素D3水平及与Th1/Th2细胞平衡变化的相关性研究[J]. 中华实用儿科临床杂志,2015, 30(4): 264-266.
[21]
Nenna R, Ferrara M, Nicolai A, et al. Viral load in infants hospitalized for respiratory syncytial virus bronchiolitis correlates with recurrent wheezing at thirty-six-month follow-up[J]. Pediatr Infect Dis J, 2015, 34(10): 1131-1132.
[22]
de Sousa RB, Medeiros D, Sarinho E, et al. Risk factors for recurrent wheezing in infants: a case-control study[J]. Rev Saude Publica, 2016, 50: 15.
[23]
田曼,赵德育,文惯宇,等. RSV毛细支气管炎及其后反复相关影响因素分析[J]. 中华实验和临床病毒学杂志,2009, 23(5): 371-374.
[24]
Aranda CS, Wandalsen G, Fonzar L, et al. Risk factors for recurrent wheezing--International Study of Wheezing in Infants (EISL) phase 3[J]. Allergol Immunopathol (Madr), 2016, 44(1): 3-8.
[25]
曹向可,王维,钱庆增,等. 3岁以下婴幼儿喘息的危险因素分析[J]. 广东医学,2017, 38 (10): 1548-1551.
[26]
Miller EK, Avila PC, Khan YW, et al. Wheezing exacerbations in early childhood: evaluation, treatment, and recent advances relevant to the genesis of asthma[J]. J Allergy Clin Immunol Pract, 2014, 2(5): 537-543.
[27]
单文婕,卢燕鸣,李亚琴,等. 婴幼儿反复喘息危险因素Meta分析[J]. 中华实用儿科临床杂志,2015, 30(10): 761-764.
[28]
Zeiger RS, Mauger D, Bacharier LB, et al. Daily or intermittent budesonide in preschool children with recurrent wheezing[J]. N Engl J Med, 2011, 365(21): 1990-2001.
[29]
Tenero L, Piazza M, Piacentini G, et al. Recurrent wheezing in children[J]. Transl Pediatr, 2016, 5(1): 31-36.
[30]
Beigelman A, Bacharier LB. Management of preschool recurrent wheezing and asthma: a phenotype-based approach[J]. Curr Opin Allergy Clin Immunol, 2017, 17(2): 131-138.
[31]
Sears MR. Predicting asthma outcomes[J]. J Allergy Clin Immunol, 2015, 136(4): 829-836.
[32]
储昭乐,彭美芳,李章. 吸入糖皮质激素预防毛细支气管炎后喘息随机对照试验的Meta分析[J/CD]. 中华临床医师杂志(电子版), 2013, 7(19): 8813-8820.
[33]
徐红艳,周罗根. 婴幼儿毛细支气管炎后喘息的干预[J]. 实用临床医药杂志,2014, 18(24): 150-160.
[34]
Peng WS, Chen X, Yang XY, et al. Systematic review of montelukast′s efficacy for reventing post-bronchiolitis wheezing[J]. Pediatr Allergy Immunol, 2014, 25(2): 143-150.
[35]
Stokholm J, Chawes BL, Vissing NH, et al. Azithromycin for episodes with asthma-like symptoms in young children aged 1-3 years: a randomised, double-blind, placebo-controlled trial[J]. Lancet Respir Med, 2016, 4(1): 19-26.
[36]
Beigelman A, Isaacson-Schmid M, Sajol G, et al. Randomized trial to evaluate azithromycin′s effects on serum and upper airway IL-8 levels and recurrent wheezing in infants with respiratory syncytial virus bronchiolitis[J]. J Allergy Clin Immunol, 2015, 135(5): 1171-1178.
[37]
田野,嵇若旭,鲍一笑,等. 阿奇霉素在婴幼儿喘息联合降阶梯疗法中的疗效[J]. 中华实用儿科杂志,2014, 29(4): 261-264.
[38]
Mochizuki H, Kusuda S, Okada K, et al. Palivizumab prophylaxis in preterm infants and subsequent recurrent wheezing: 6 year follow up study[J]. Am J Respir Crit Care Med, 2017, 196(1): 29-38.
[39]
Lemanske RF Jr. Early life wheezing and respiratory syncytial virus prevention[J]. N Engl J Med, 2013, 368(19): 1839-1841.
[40]
黄花荣,曾森强,吴敬芳. 大剂量丙种球蛋白对喘息婴儿外周血IL-4和CD20水平以及喘息再发的影响[J]. 中国病理生理杂志,2010, 26(8): 1575-1578.
[41]
李缙. 静脉滴注丙种球蛋白治疗毛细支气管炎的临床疗效观察[J]. 儿科药学杂志,2017, 28(8): 32-35.
[1] Peng Yuan. Advancement of HER-2 positive breast cancer treatment in 2023[J]. Chinese Journal of Breast Disease(Electronic Edition), 2024, 18(02): 66-70.
[2] Lili Lei, Xiaofeng Yu, Yuanyuan Wang, Yingjun Xu. Expression and clinical significance of NLRP3 and TLR4 in peripheral blood of children with acute wheezing caused by human rhinovirus[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 440-445.
[3] Lin Yang, Rutie Yin. Current research status on etiology and treatment of patients with white lesions of vulva[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(02): 157-165.
[4] Yufan Meng, Yongzheng Li, Zhiyao Fan, Hanxiang Zhan. Mechanism and research progress in intratumoral microbiota in the pathogenesis and progression of pancreatic cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(04): 577-582.
[5] Jing Zhao, Jiaxin Zhang, Yan Gao, Xisheng Xie. Progress of research on minimal change disease in its pathogenesis and treatment[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(04): 207-212.
[6] Ding Sun, Bin Wang, Xiangmei Chen, Yizhi Chen. Progress in the study of heat stress nephropathy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2024, 13(03): 170-176.
[7] Hongyan Jia, Dan Wang, Ranran Zhang, Qian Ma, Yonghong Jiao. Genetic analysis on the pathogenesis of Möbius syndrome based on whole exome sequencing[J]. Chinese Journal of Ophthalmologic Medicine(Electronic Edition), 2024, 14(03): 146-154.
[8] Yanan An, Duanran Wang, Tiantian Guo, Xirun Wu. Research progress of Helicobacter pylori negative gastric mucosa-associated lymphoid tissue lymphoma[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(03): 268-274.
[9] Qi Liu, Shoukai Wang, Shuai Wang, Yuqing Su, Zhuang Ma, Haijun Chen, Pilei Si. Advances in research of intratumoral microbiome in breast cancer[J]. Chinese Journal of Clinicians(Electronic Edition), 2024, 18(09): 841-845.
[10] Qiuyi Chen, Xi Lin, Zhenyin Liu. Advances in the molecular mechanism of lymphatic malformations[J]. Chinese Journal of Interventional Radiology(Electronic Edition), 2024, 12(04): 374-379.
[11] Ruifang Hu, Lijuan Fan. Research progress on diagnostic biomarkers of esophageal squamous intraepithelial neoplasia and status of non-endoscopic treatment[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(04): 281-286.
[12] Ruonan Li, Jin Song, Yuzhong Wang. Progress on the pathogenesis and diagnosis and treatment of postherpetic neuralgia[J]. Chinese Journal of Diagnostics(Electronic Edition), 2024, 12(03): 199-205.
[13] Kehan Wang, Tao Xu, Quanhong Zhou. Research progress on perioperative delirium and stress[J]. Chinese Journal of Geriatrics Research(Electronic Edition), 2024, 11(03): 45-49.
[14] Yuanxin Lu, Lilin Gong, Menghua Zeng. Research progress in the relationship between obesity and non-alcoholic fatty liver disease[J]. Chinese Journal of Obesity and Metabolic Diseases(Electronic Edition), 2024, 10(02): 113-119.
[15] Yue Yu, Yuan Wang, Muhui Sang, Qin Shi. Analysis of vertigo pathogenesis syndrome element distribution using a vertigo syndrome differentiation scale[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 454-458.
Viewed
Full text


Abstract