Comparison Study on the Efficacy of Bronchiolitis Between Different Dosage of Nebulised Budesonide Suspension for Inhalation

doi:10.3877/cma.j.issn.1673-5250.2013.01.013

Objective

To evaluate the clinical features of children with bronchiolitis, and compared their treatment response between different dosage of nebulised budesonide suspension for inhalation.

Methods

From January to December 2011, a total of 157 cases of children with bronchiolitis were recruited. Related clinical data of children diagnosed and administrated were collected and analyzed by soft ware SPSS 19.0. The patients were randomly divided into low dose group(n=78) and high dose group(n=79), they were nebulised budesonide suspension for inhalation 0.5 mg once and 1.0 mg once, respectively. Informed consent was obtained from the parents of each participating child. There had no significance difference between two groups among age, gender ratio and classified of bronchiolitis evaluated(P>0.05).

Results

At treatment 30 minutes, children with mild bronchiolitis, Beck score, respiratory frequency in high dose group were much lower than those in low dose group(P<0.001, P=0.01), pulse oxygen saturation in high dose group was statistically higher than that in low dose group(t=3.596, P<0.001). The same result could be seen in children with severe bronchiolitis. At treatment 60 minutes, children with mild bronchiolitis, Beck score, respiratory frequency in high dose group were much lower than those in low dose group(P=0.003, P=0.001), pulse oxygen saturation in high dose group was much higher than that in low dose group(t=4.593, P<0.001), The same result could be seen in children with severe bronchiolitis. There had no significance difference between high and low dose group in hospitalization time and expenses (P<0.05), and those in high dose group were much shorter and less cost.

Conclusions

Treatment by 1.0 mg budesonide suspension, response of children with bronchiolitis are much better than that of 0.5 mg group. Related clinical data include faster changing in Beck clinical score, respiratory frequency, pulse oxygen saturation; shorter hospitalization time and less cost of hospitalization expenses.

Key words: bronchiolitis, budesonide suspension, dosage, clinical effect, child

图1 小儿毛细支气管炎发病的好发季节比较

Figure 1 Comparison of seasonal occurrence rate of bronchiolitis

表1 两组患儿治疗前及接受0.5 mg与1.0 mg雾化吸入治疗30 min，60 min时的Beck评分比较(分，±s)

Table 1 Comparison of Beck score between two groups at admission, and treatment 30 min, 60 min (score，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	10.35±2.14	8.63±1.52^a	7.63±0.52^a
?	低剂量组	24	10.23±2.17	9.56±1.75^b	8.72±0.74^a
?	t	?	－0.198	2.040	7.042
?	P	?	0.844	0.047	<0.001
轻度患儿		?	?	?	?
?	高剂量组	53	5.65±1.28	5.02±0.21^a	4.81±0.41^a
?	低剂量组	54	5.72±1.21	5.18±0.36^a	5.02±0.53^a
?	t	?	0.861	4.293	3.069
?	P	?	0.391	<0.001	0.003

表1 两组患儿治疗前及接受0.5 mg与1.0 mg雾化吸入治疗30 min，60 min时的Beck评分比较(分，±s)

Table 1 Comparison of Beck score between two groups at admission, and treatment 30 min, 60 min (score，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	10.35±2.14	8.63±1.52^a	7.63±0.52^a
?	低剂量组	24	10.23±2.17	9.56±1.75^b	8.72±0.74^a
?	t	?	－0.198	2.040	7.042
?	P	?	0.844	0.047	<0.001
轻度患儿		?	?	?	?
?	高剂量组	53	5.65±1.28	5.02±0.21^a	4.81±0.41^a
?	低剂量组	54	5.72±1.21	5.18±0.36^a	5.02±0.53^a
?	t	?	0.861	4.293	3.069
?	P	?	0.391	<0.001	0.003

表2 两组患儿治疗前及接受雾化吸入治疗30 min，60 min时的呼吸频率比较(次/min，±s)

Table 2 Comparison of respiratory rate between two groups at admission, and treatment 30 min, 60 min (/min，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	56.42±4.97	49.43±3.95^a	45.32±6.87^a
?	低剂量组	24	55.71±5.23	52.15±4.32^a	49.50±7.12^a
?	t	?	－0.448	2.311	2.087
?	P	?	0.628	0.025	0.042
轻度患儿		?	?	?	?
?	高剂量组	53	48.31±4.95	41.92±6.83^a	40.21±5.07^a
?	低剂量组	54	47.12±5.09	44.27±7.12^a	43.17±4.59^a
?	t	?	－1.160	－2.628	3.322
?	P	?	0.249	0.010	0.001

表2 两组患儿治疗前及接受雾化吸入治疗30 min，60 min时的呼吸频率比较(次/min，±s)

Table 2 Comparison of respiratory rate between two groups at admission, and treatment 30 min, 60 min (/min，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	56.42±4.97	49.43±3.95^a	45.32±6.87^a
?	低剂量组	24	55.71±5.23	52.15±4.32^a	49.50±7.12^a
?	t	?	－0.448	2.311	2.087
?	P	?	0.628	0.025	0.042
轻度患儿		?	?	?	?
?	高剂量组	53	48.31±4.95	41.92±6.83^a	40.21±5.07^a
?	低剂量组	54	47.12±5.09	44.27±7.12^a	43.17±4.59^a
?	t	?	－1.160	－2.628	3.322
?	P	?	0.249	0.010	0.001

表3 两组患儿治疗前及接受雾化吸入治疗30 min，60 min时的血氧饱和度比较(%，±s)

Table 3 Comparison of pulse oxygen saturation between two groups at admission, and treatment 30 min, 60 min (%，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	90.87±2.95	95.79±2.41^a	97.63±2.28^a
?	低剂量组	24	91.26±3.12	93.36±2.73^a	95.52±3.46^a
?	t	?	0.454	－3.349	－2.562
?	P	?	0.652	0.002	0.014
轻度患儿		?	?	?	?
?	高剂量组	53	93.81±3.23	97.41±2.15^a	98.42±1.49^a
?	低剂量组	54	93.52±3.18	95.41±3.52^a	96.53±2.73^a
?	t	?	－0.390	－3.596	－4.593
?	P	?	0.698	<0.001	<0.001

表3 两组患儿治疗前及接受雾化吸入治疗30 min，60 min时的血氧饱和度比较(%，±s)

Table 3 Comparison of pulse oxygen saturation between two groups at admission, and treatment 30 min, 60 min (%，±s)

组别		n	治疗前	30 min时	60 min时
重度患儿		?	?	?	?
?	高剂量组	26	90.87±2.95	95.79±2.41^a	97.63±2.28^a
?	低剂量组	24	91.26±3.12	93.36±2.73^a	95.52±3.46^a
?	t	?	0.454	－3.349	－2.562
?	P	?	0.652	0.002	0.014
轻度患儿		?	?	?	?
?	高剂量组	53	93.81±3.23	97.41±2.15^a	98.42±1.49^a
?	低剂量组	54	93.52±3.18	95.41±3.52^a	96.53±2.73^a
?	t	?	－0.390	－3.596	－4.593
?	P	?	0.698	<0.001	<0.001

表4 两组患儿平均住院时间、住院费用比较 (±s)

Table 4 Comparison of hospitalization time and expenses between two groups(±s)

组别		n	住院时间(d)	住院费用(元)
重度患儿		?	?	?
?	高剂量组	26	8.62±2.67	2573±196
?	低剂量组	24	10.73±3.27	2816±184
?	t	?	2.504	4.556
?	P	?	0.016	<0.001
轻度患儿		?	?	?
?	高剂量组	53	6.17±1.64	2029±213
?	低剂量组	54	7.12±1.28	2215±162
?	t	?	3.721	5.504
?	P	?	<0.001	<0.001

表4 两组患儿平均住院时间、住院费用比较 (±s)

Table 4 Comparison of hospitalization time and expenses between two groups(±s)

组别		n	住院时间(d)	住院费用(元)
重度患儿		?	?	?
?	高剂量组	26	8.62±2.67	2573±196
?	低剂量组	24	10.73±3.27	2816±184
?	t	?	2.504	4.556
?	P	?	0.016	<0.001
轻度患儿		?	?	?
?	高剂量组	53	6.17±1.64	2029±213
?	低剂量组	54	7.12±1.28	2215±162
?	t	?	3.721	5.504
?	P	?	<0.001	<0.001

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