Comparative Study of Methylprednisolone and Hydrocortisoneon Treatment of Bronchiolitis

doi:10.3877/cma.j.issn.1673-5250.2010.02.013

Objective

To compare therapeutic effects between methylprednisolone and hydrocortisone on treatment of bronchiolitis.

Methods

From January 2008 to July 2009, 63 children with bronchiolitis were randomly divided into two groups, 31 cases were treated with methylprednisolone (1-2 )mg/(kg·d)×5-day+ aminofilina (3 mg/kg) intravenous infusion under conventional therapy (treatment group), another 32 cases were treated with hydrocortisone(5-10) mg/(kg·d) ×5-day+ aminofilina (3 mg/kg) intravenous infusion under conventional therapy (control group). Both groups were changed to oral administration when symptoms improved. Informed consent was obtained from all participants. Comparison between gender, ages, symptoms, and physical signs had no significant.

Results

The total effective rate of treatment group was significantly higher than that of control group(25/31, 80.65% vs. 17/32, 53.13%, P<0.05), and the hospitalize time of treatment group was significantly shorter than that of control group [(7.03±1.22)d vs.(9.75±1.41)d, P<0.05].

Conclusion

Methyprednisolone is effective and safe in treatment of bronchiolitis.

Key words: methylprednisolone, hydrocortisone, bronchiolitis

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