Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (03): 217 -220. doi: 10.3877/cma.j.issn.1673-5250.2009.03.104

Original Article

Meta Analysis of the Clinical Efficiency of Gangliosides on Children With Cerebral Palsy.

Lin-yin LUO, Fan YANG, Jin-rong LI, Ming-yu LEI   

  1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Published:2009-06-01
Objective

To evaluate the efficiency of gangliosides(GM-1) in the treatment of cerebral palsy (CP).

Methods

Eligible studies were identified by searching Cochrane library, MedLine, CNKI and VIP. No language restrictions were applied. Two reviewers assessed the quality of included studies and extracted data and processed meta-analysis. All randomized and quasi-randomized trials comparing treatment with and without gangliosides with clinical endpoints were reviewed. Development quotient(DQ) was measured by Gesell. RevMan 4.3.2 was used to do the statistical analysis.

Results

Four trials involving 325 patients with cerebral palsy were included. All trials were case-control trials. Meta analysis indicated that using the gangliosides could alter the symptoms and signs for the better [RR=1.24, 95%CI(0.95, 1.62)], and developmental quotient values increased [RR=1.20, 95%CI(1.06, 1.36)], and there were statistic significance.

Conclusion

Gangliosides combined with other treatments can improve the manifestations and developmental quotient of cerebral palsy. However, due to all included trials are not randomized trial controlled (RTC), and numbers of patients of these trials are relatively small, more well-designed multi-center randomized controlled trials should be performed.

图1 神经节苷脂+基础康复治疗与单纯基础康复治疗对脑瘫患儿的症状及体征改善比较
图2 神经节苷脂+基础康复治疗与单纯基础康复治疗对脑瘫患儿发育商影响的比较
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