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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2013, Vol. 09 ›› Issue (03): 357 -360. doi: 10.3877/cma.j.issn.1673-5250.2013.03.017

Special Issue: ；

Original Article

Relationship Between BsmⅠ Vitamin D Receptor Gene Polymorphism and Childhood Type 1 Diabetes Mellitus: A Meta-Analysis

Ling-fei WANG1(), Yao-dong ZHANG1, Hai-yan WEI1   

  1. 1. Department of Endocrinology, Zhengzhou Children's Hospital, Zhengzhou 450052, Henan Province, China
  • Received:2013-02-25 Revised:2013-05-15 Published:2013-06-01
  • Corresponding author: Ling-fei WANG
  • About author:
    (Corresponding author: WANG Ling-fei, Email: )
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Objective

To explore the correlation of BsmⅠ vitamin D receptor (VDR) gene polymorphism and type 1 diabetes mellitus(T1DM) in children.

Methods

Taking"VDR","vitamin D receptor","T1DM","type 1 diabetes mellitus","gene polymorphism"as the key words, We searched PubMed, Cochrane Library, EMbase, Springer, Ovid, Chinese Journal Full-text Database (CNKI), China Biology Medicine (CBM) and Wanfang Data to collected all the publications about the correlation between BsmⅠ VDR gene polymorphism and T1DM in children. Meta-analysis was performed for checking the difference between two groups about genotypes such as Bb, bb, Bb+ bb by Revman 5.1 software.

Results

A total of 7 studies involving 948 T1DM children and 1055 healthy children were included in the Meta-analysis.According to the heterogeneity test results of these studies, pooled OR value(95%CI) of Meta-analysis of Bb, bb, Bb+ bb genotype of BsmⅠ VDR gene polymorphism by fixed effect model were 0.68(0.48-0.96), 0.64(0.47-0.88) and 0.63 (0.48-0.82).

Conclusions

This Meta-analysis demonstrates the correlation between BsmⅠ VDR gene polymorphism and T1DM in children.

Key words: Meta-analysis, vitamin D receptor, type 1 diabetes mellitus, gene polymorphism, child
表1 7篇纳入文献的基本资料
Table 1 General data of seven included studies
纳入文献 发表时间(年) 来源国家 T1DM组基因型 对照组基因型 NOS评分
n BB Bb bb n BB Bb bb
Chang等[6] 2000 中国台湾 157 4 16 137 248 1 16 231 8
García等[7] 2007 智利 216 21 110 77 203 14 74 115 7
Gy?rffy等[8] 2002 匈牙利 107 17 53 35 103 18 44 40 6
Mory等[9] 2009 巴西 189 60 57 60 194 38 74 70 7
Panierakis等[10] 2009 希腊 96 38 43 15 100 23 57 20 8
San-Pedro等[11] 2005 西班牙 71 15 40 16 88 17 44 27 8
Skrabi?等[12] 2003 克罗地亚 134 24 58 52 132 17 74 41 7
图1 VDR基因BsmⅠ位点Bb基因型与儿童T1DM的关系
Figure 1 Relationship of Bb genotype of BsmⅠ VDR gene polymorphism and susceptibility to type 1 diabetes
图2 VDR基因BsmⅠ位点bb基因型与儿童T1DM的关系
Figure 2 Relationship of bb genotype of BsmⅠ VDR gene polymorphism susceptibility to type 1 diabetes
图3 VDR基因BsmⅠ位点Bb＋bb基因型与儿童T1DM的关系
Figure 3 Relationship of Bb＋bb genotype of BsmⅠ VDR gene polymorphism susceptibility to type 1 diabetes
表2 两种效应模型对Bb，bb，Bb＋bb基因型的OR值及其95%CI比较
Table 2 Comparison of OR value(95%CI) of Bb，bb，Bb＋bb genotype between two effect models
基因型 随机效应模型 固定效应模型
OR值 95%CI OR值 95%CI
Bb 0.66 0.50～0.87 0.68 0.49～0.96
bb 0.64 0.47～0.87 0.64 0.47～0.88
Bb＋bb 0.62 0.48～0.80 0.63 0.48～0.82
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