Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (01): 18 -22. doi: 10.3877/cma.j.issn.1673-5250.2009.01.107

Original Article

Prospective Cohort Research on Cervical Carcinoma Screening of Thinprep Cytological Test Combined With Human Papilloma Virus Hybrid Capture Ⅱ

Ping LIU, Yan-li LIU   

  1. Department of Obstetrics and Gynecology, Hexian Memorial Hospital, Guangzhou 511400, China
  • Published:2009-02-01
  • Supported by:
    * Project No. 2007–YB–189, supported by the Guangzhou Medicine Health Science and Technology
Objective

To investigate the screening value of the thinprep cytological test(TCT) detection combined with human papilloma virus(HPV) hybrid capture Ⅱ(HC-Ⅱ) for cervical carcinoma.

Methods

From January 2003 to January 2005, the thinprep cytological test and hybrid capture Ⅱ were applied to screen cervical carcinoma in 435 cases in the Department of Obstetrics and Gynecology in Hexian Memorial Hospital. The thinprep cytological test was applied to detect cervical carcinoma cytology, and hybrid capture Ⅱ was applied to detect human papilloma virus. According to the detection results, all cases were divided into 4 groups, group of HPV(-), TCT(-), group of HPV(+ ), TCT(-), group of HPV(-), TCT(+ ), group of HPV(+ ), TCT(+ ). A follow-up of 3 years had been carried out, and different groups were checked by the thinprep cytological test and human papilloma virus hybrid capture Ⅱ at different interval times, and colpomicroscope, biopsy and endocervical curettage (ECC) would also be used if necessary. Determinant elements of cytology occurrence were evaluated by the Logistic regression analysis.

Results

The sensitivity, specificity, efficiency, positive predictive value (PPV), negative predictive value(NPV), Kappa values of the thinprep cytological test and human papilloma virus hybrid capture Ⅱwere 85.9%, 96.2%, 94.7%, 79.7%, 97.5%, 0.7959, and 92.2%, 80.1%, 81.8%, 44.4%, 98.3%, 0.4996. The group of HPV(+ ), TCT(-), and the group of HPV(-), TCT(+ ) had higher risk of pathological changes of cervical carcinoma (RR=45.033, 95%CI 17.140~118.313; RR=235.886, 95% CI 70.694~487.088) compared with the group of HPV(-), TCT(-), and the group of HPV(+ ), TCT(+ ) had distinct risks (RR=464.400, 95% CI 105.162~950.806).

Conclusion

The detection of sensitivity and specificity by the combination of the thinprep cytological test with human papilloma virus hybrid capture Ⅱ can be enhanced, which could meet the requirement of screening the early stage of cervical carcinomas and precancerous changes.

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