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中华妇幼临床医学杂志(电子版) ›› 2023, Vol. 19 ›› Issue (05) : 497 -504. doi: 10.3877/cma.j.issn.1673-5250.2023.05.001

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宫颈癌治疗研究现状
马敏榕, 李聪, 周勤()   
  1. 重庆医科大学附属第一医院妇产科,重庆 400000
  • 收稿日期:2023-04-17 修回日期:2023-09-08 出版日期:2023-10-01
  • 通信作者: 周勤

Current research status of treatment of cervical cancer

Minrong Ma, Cong Li, Qin Zhou()   

  1. Department of Gynaecology and Obstetrics, First Affiliated Hospital of Chongqing Medical University, Chongqing 400000, China
  • Received:2023-04-17 Revised:2023-09-08 Published:2023-10-01
  • Corresponding author: Qin Zhou
  • Supported by:
    National Natural Science Foundation of China for Youths(81100399)
引用本文:

马敏榕, 李聪, 周勤. 宫颈癌治疗研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2023, 19(05): 497-504.

Minrong Ma, Cong Li, Qin Zhou. Current research status of treatment of cervical cancer[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 497-504.

2022年《全球癌症统计报告》显示,全球女性中宫颈癌发病率位居妇科3大恶性肿瘤之首,在美国宫颈癌是女性第4类最常见妇科癌症,也是恶性肿瘤导致女性相关死亡的第4大原因。国际妇产科联盟(FIGO)临床分期为晚期或复发性宫颈癌患者的预后较差,是导致该病患者死亡的主要原因。宫颈癌的经典治疗方案包括放疗、化疗及手术治疗等。但是这些治疗方式的疗效,可能对某些患者,尤其是对晚期或复发性宫颈癌患者并不佳。近年研究发现,病毒基因整合、细胞氧化应激、血管内皮生长因子(VEGF)、表皮生长因子(EGFR)、程序性细胞死亡受体(PD)-1等多种相关信号通路对宫颈癌的发生、发展起着重要作用,基于这些信号通路的多种新型治疗策略被开发及临床应用,为更多晚期或复发性宫颈癌患者的治疗带来了希望。此外,仍有大量关于宫颈癌干细胞(CCSC)、外泌体微小RNA(miR)-651等宫颈癌潜在治疗靶点的研究正在开展中。笔者拟就宫颈癌的新辅助化疗(NACT)、药物靶向治疗、免疫治疗、治疗性疫苗接种及光化学疗法(PDT) 5种新型治疗方案及其潜在治疗靶点的最新研究进展进行阐述。

According to the 2022 Global Cancer Statistics Report, the incidence of uterine cervical neoplasms ranks first among third major gynecological malignancies in the world, it is the fourth most common type of gynecological cancer in women, and is also the fourth leading cause of malignancy related death in women in the United States. According to International Federation of Obstetrics and Gynecology (FIGO), patients with advanced or recurrent cervical cancer have a poor prognosis and are the leading cause of death from uterine cervical neoplasms. The classical treatments of cervical cancer include radiotherapy, chemotherapy and surgery, etc.. However, the effectiveness of these treatments may not be good to some patients, especially those patients with advanced or recurrent uterine cervical neoplasms. Recent research have found that viral gene integration, cellular oxidative stress, vascular endothelial growth factor (VEGF), epidermal growth factor (EGFR), programmed cell death receptor (PD)-1 and other related signaling pathways play an important role in uterine cervical neoplasms occurrence and development. A variety of novel and emerging therapeutic strategies based on these signaling pathways have been developed and applied clinically, bringing hope for treatment of more patients with advanced or recurrent uterine cervical neoplasms. In addition, there are still a lot of researches on uterine cervical neoplasms stem cells (CCSC), exosome microRNA (miR)-651 and other potential therapeutic targets of uterine cervical neoplasms is under way. The authors intend to review the latest research progresses of 5 new therapeutic schemes of neoadjuvant chemotherapy (NACT), drug targeted therapy, immunotherapy, therapeutic vaccine and photodynamic therapy (PDT), and their potential therapeutic targets for uterine cervical neoplasms.

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