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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (04) : 472 -475. doi: 10.3877/cma.j.issn.1673-5250.2019.04.020

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综述

抗精神病药与高催乳素血症及月经紊乱
游小林1, 谢聪1   
  1. 1. 电子科技大学医学院附属医院·成都市妇女儿童中心医院妇产科 610041
  • 收稿日期:2019-01-10 修回日期:2019-07-16 出版日期:2019-08-01

Hyperprolactinemia and menstrual disorder caused by antipsychotics

Xiaolin You1, Cong Xie1   

  1. 1. Department of Obstetrics and Gynecology, The Affiliated Hospital, School of Medicine, USETC Chengdu Women′s & Children′s Central Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2019-01-10 Revised:2019-07-16 Published:2019-08-01
  • About author:
    Corresponding author: Gan Xiaoqin, Email:
  • Supported by:
    Program of Health and Family Planning Commission of Sichuan Province(17PJ412)
引用本文:

游小林, 谢聪. 抗精神病药与高催乳素血症及月经紊乱[J/OL]. 中华妇幼临床医学杂志(电子版), 2019, 15(04): 472-475.

Xiaolin You, Cong Xie. Hyperprolactinemia and menstrual disorder caused by antipsychotics[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(04): 472-475.

抗精神病药(APS)可被分为典型APS和非典型APS。高催乳素血症(HPRL)表现为外周血循环中催乳素水平异常增高。所有典型APS与非典型APS中的利培酮,均可导致女性精神疾病患者血清催乳素水平较正常值显著升高。多数非典型APS仅导致血清催乳素水平短暂、轻微增高,甚至对血清催乳素水平无影响。APS所致HPRL是导致女性精神疾病患者月经紊乱,甚至闭经的主要原因之一。目前针对APS所致HPRL及月经紊乱、闭经治疗的主要措施为降低催乳素水平。不同APS所致HPRL及月经紊乱发生率不同,临床准确评估和管理HPRL,可提高女性精神疾病患者的生活质量及治疗依从性。笔者拟就APS治疗女性精神疾病患者时导致的HPRL与月经紊乱不良反应的处理进行阐述,以期为临床降低该类患者的不良反应提供参考。

Antipsychotics (APS) can be divided into typical and atypical APS. Hyperprolactinemia (HPRL) is characterized by an abnormal increase in prolactin level of peripheral blood circulation. All typical APS and atypical APS risperidone can lead to the serum prolactin level of women with mental illness significantly higher than normal value. While most atypical APS only result in transient and slightly increase of serum prolactin level or even do not lead to the increase of serum prolactin level. HPRL caused by APS is one of the main reasons for menstrual disorders and amenorrhea in women with mental illness. The treatments of HPRL, menstrual disorders and amenorrhea caused by APS are mainly to reduce level of prolactin. The incidences of HPRL and menstrual disorders caused by different APS are different. Accurate clinical evaluation and management of HPRL can improve the quality of life and compliance of female psychiatric patients. This review expounds the treatment of adverse reactions HPRL and menstrual disorders caused by APS in treatment of female psychiatric patients, in order to provide reference for clinical reduction of adverse reactions in female psychiatric patients.

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