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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (04) : 468 -471. doi: 10.3877/cma.j.issn.1673-5250.2019.04.019

所属专题: 文献

综述

川崎病体外研究现状
郑小兰1, 吴刚1,(), 张怡1, 华益民1, 周开宇1   
  1. 1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2019-03-09 修回日期:2019-07-01 出版日期:2019-08-01
  • 通信作者: 吴刚

In vitro study status of Kawasaki disease

Xiaolan Zheng1, Gang Wu1,(), Yi Zhang1, Yimin Hua1, Kaiyu Zhou1   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2019-03-09 Revised:2019-07-01 Published:2019-08-01
  • Corresponding author: Gang Wu
  • About author:
    Corresponding author: Wu Gang, Email:
  • Supported by:
    National Natural Science Foundation of China(81571515); Science and Technology Program for Wellbeing of Chengdu Science and Technology Bureau(2015-HM01-00456-SF)
引用本文:

郑小兰, 吴刚, 张怡, 华益民, 周开宇. 川崎病体外研究现状[J]. 中华妇幼临床医学杂志(电子版), 2019, 15(04): 468-471.

Xiaolan Zheng, Gang Wu, Yi Zhang, Yimin Hua, Kaiyu Zhou. In vitro study status of Kawasaki disease[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(04): 468-471.

川崎病(Kawasaki disease)是一种主要发生在5岁以下婴幼儿的全身中小动脉血管炎,是发达国家儿童获得性心脏病的最常见病因。临床对于川崎病的发病机制迄今尚未阐明。随着近年分子生物学技术的发展,对川崎病的研究取得很大进步。笔者拟从基因组学、蛋白质组学、外泌体3个方面,对川崎病的体外研究现状进行阐述。

Kawasaki disease is a systemic vasculitis mainly occurs in the middle and small arteries in children under five years old. It has been proved to be the main causation of acquired heart diseases of children in developed countries. The pathogenesis of Kawasaki disease is still unknown, but great progresses have been made in vitro studies of Kawasaki disease with the rapid development of molecular biotechnology in recent years. This article focuses on in vitro research status of Kawasaki disease including genomics, proteomics and exosomes.

[1]
Newburger JW. Kawasaki disease: state of the art[J]. Congenit Heart Dis, 2017, 12(5): 633-635.
[2]
Daniels LB, Burns JC. Adjunctive testing in the evaluation of adults after Kawasaki disease[J]. Circ J, 2015, 79(11): 2299-2305.
[3]
McCrindle BW, Rowley AH, Newburger JW, et al. Diagnosis, treatment, and long-term management of Kawasaki disease: a scientific statement for health professionals from the American heart association[J]. Circulation, 2017, 135(17): e927-e999.
[4]
Onouchi Y. The genetics of Kawasaki disease[J]. Int J Rheum Dis, 2018, 21(1): 26-30.
[5]
Kataoka M, Wang DZ. Non-coding RNAs including miRNAs and lncRNAs in cardiovascular biology and disease[J]. Cells, 2014, 3(3): 883-898.
[6]
Wang H, Peng R, Wang J, et al. Circulating microRNAs as potential cancer biomarkers: the advantage and disadvantage[J]. Clin Epigenetics, 2018, 10(1): 59.
[7]
Mohr AM, Mott JL. Overview of microRNA biology[J]. Semin Liver Dis, 2015, 35(1): 3-11.
[8]
Shimizu C, Kim J, Stepanowsky P, et al. Differential expression of miR-145 in children with Kawasaki disease[J]. PLoS One, 2013, 8(3): e58159.
[9]
Ni FF, Li CR, Li Q, et al. Regulatory T cell microRNA expression changes in children with acute Kawasaki disease[J]. Clin Exp Immunol, 2014, 178(2): 384-393.
[10]
褚茂平,胡晨,周爱华,等. 川崎病血清特异相关miR-23a对人脐静脉内皮细胞生长及迁移的影响[J]. 温州医科大学学报,2015, 45(5): 321-326.
[11]
Chu M, Wu R, Qin S, et al. Bone marrow-derived microRNA-223 works as an endocrine genetic signal in vascular endothelial cells and participates in vascular injury from Kawasaki disease[J]. J Am Heart Assoc, 2017, 6(2): e004878.
[12]
He M, Chen Z, Martin M, et al. miR-483 targeting of CTGF suppresses endothelial-to-mesenchymal transition: therapeutic implications in Kawasaki disease[J]. Circ Res, 2017, 120(2): 354365.
[13]
Wu R, Shen D, Sohun H, et al. miR-186, a serum microRNA, induces endothelial cell apoptosis by targeting SMAD6 in Kawasaki disease[J]. Int J Mol Med, 2018, 41(4): 1899-1908.
[14]
Rinn JL, Chang HY. Genome regulation by long noncoding RNAs[J]. Annu Rev Biochem, 2012, 81: 145-166.
[15]
Salviano-Silva A, Lobo-Alves SC, Almeida RC, et al. Besides pathology: long non-coding RNA in cell and tissue homeostasis[J]. Noncoding RNA, 2018, 4(1): 3.
[16]
Batista PJ, Chang HY. Long noncoding RNAs: cellular address codes in development and disease[J]. Cell, 2013, 152(6): 1298-1307.
[17]
Li Z, Chao TC, Chang KY, et al. The long noncoding RNA THRIL regulates TNFα expression through its interaction with hnRNPL[J]. Proc Natl Acad Sci USA, 2014, 111(3): 1002-1007.
[18]
刘秉文,陈俊杰. 医学分子生物学[M]. 2版. 北京:中国协和医科大学出版社,2005: 532-533.
[19]
Suppers A, van Gool AJ, Wessels HJCT. Integrated chemometrics and statistics to drive successful proteomics biomarker discovery[J]. Proteomes, 2018, 6(2): 20.
[20]
Yu HR, Kuo HC, Sheen JM, et al. A unique plasma proteomic profiling with imbalanced fibrinogen cascade in patients with Kawasaki disease[J]. Pediatr Allergy Immunol, 2009, 20(7): 699-707.
[21]
Kentsis A, Shulman A, Ahmed S, et al. Urine proteomics for discovery of improved diagnostic markers of Kawasaki disease[J]. EMBO Mol Med, 2013, 5(2): 210-220.
[22]
Zhang L, Jia HL, Huang WM, et al. Monitoring of the serum proteome in Kawasaki disease patients before and after immunoglobulin therapy[J]. Biochem Biophys Res Commun, 2014, 447(1): 19-25.
[23]
Kuo HC, Huang YH, Chung FH, et al. Antibody profiling of Kawasaki disease using escherichia coli proteome microarrays[J]. Mol Cell Proteomics, 2018, 17(3): 472-481.
[24]
Wu HJ, Wu E. The role of gut microbiota in immune homeostasis and autoimmunity[J]. Gut Microbes, 2012, 3(1): 4-14.
[25]
Liu W, Liu C, Zhang L, et al. Molecular basis of coronary artery dilation and aneurysms in patients with Kawasaki disease based on differential protein expression[J]. Mol Med Rep, 2018, 17(2): 2402-2414.
[26]
Colombo M, Raposo G, Théry C. Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles[J]. Annu Rev Cell Dev Biol, 2014, 30(1): 255-289.
[27]
Simpson RJ, Jensen SS, Lim JW. Proteomic profiling of exosomes: current perspectives[J]. Proteomics, 2008, 8(19): 4083-4099.
[28]
Sluijter JP, Verhage V, Deddens JC, et al. Microvesicles and exosomes for intracardiac communication[J]. Cardiovasc Res, 2014, 102(2): 302-311.
[29]
Zhang L, Wang W, Bai J, et al. Proteomic analysis associated with coronary artery dilatation caused by Kawasaki disease using serum exosomes[J]. Rev Port Cardiol, 2016, 35(5): 265-273.
[30]
Zhang L, Song QF, Jin JJ, et al. Differential protein analysis of serum exosomes post-intravenous immunoglobulin therapy in patients with Kawasaki disease[J]. Cardiol Young, 2017, 27(9): 1786-1796.
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