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中华妇幼临床医学杂志(电子版) ›› 2019, Vol. 15 ›› Issue (01) : 86 -91. doi: 10.3877/cma.j.issn.1673-5250.2019.01.015

所属专题: 文献

论著

基于共词分析法分析新生儿重症监护领域超药品说明书用药现状
孙飞扬1, 杨晓燕1, 胡艳玲1, 陈大鹏1,(), 石晶1, 唐军1   
  1. 1. 四川大学华西第二医院儿科、出生缺陷与相关妇儿疾病教育部重点实验室,成都 610041
  • 收稿日期:2018-11-08 修回日期:2019-01-10 出版日期:2019-02-01
  • 通信作者: 陈大鹏

Status quo of the off-label drug use in neonatal intensive care: a co-word analysis

Feiyang Sun1, Xiaoyan Yang1, Yanling Hu1, Dapeng Chen1,(), Jing Shi1, Jun Tang1   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-11-08 Revised:2019-01-10 Published:2019-02-01
  • Corresponding author: Dapeng Chen
  • About author:
    Corresponding author: Chen Dapeng, Email:
  • Supported by:
    National Key Development Program of Clinical Specialist (Neonatologist)(1311200003303); Youth Foundation of National Natural Science Foundation of China(81300524); Applied Basic Research Program of Science and Technology Department of Sichuan Province(2016JY0180); Foundation of Health and Family Planning Commission of Sichuan Province(150104, 150107); Applied Basic Research Program of Science and Technology Department of Sichuan Province(2011JY0085); Innovation Program of Sichuan Medical Association Science for Youth(Q14036)
引用本文:

孙飞扬, 杨晓燕, 胡艳玲, 陈大鹏, 石晶, 唐军. 基于共词分析法分析新生儿重症监护领域超药品说明书用药现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2019, 15(01): 86-91.

Feiyang Sun, Xiaoyan Yang, Yanling Hu, Dapeng Chen, Jing Shi, Jun Tang. Status quo of the off-label drug use in neonatal intensive care: a co-word analysis[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2019, 15(01): 86-91.

目的

探讨采用共词分析法对基于文献报道的国内外新生儿重症监护领域超药品说明书用药(OLDU)现状,旨在为该领域OLDU研究提供方向。

方法

本研究以"新生儿重症监护""超说明书用药"为中文关键词,在中国知网(CNKI)数据库、万方数据库中进行文献检索;同时,以"neonatal intensive care""off-label drug"为英文关键词,在MEDLINE数据库中进行检索。设定文献检索时间为各个数据库建库至2018年6月31日。选择由此获取的符合本研究纳入标准与排除标准的42篇新生儿童症监护领域OLDU相关文献为研究对象。其中,中文文献为3篇,英文文献为39篇。采用Microsoft Office Excel 2016软件对39篇英文文献关键词进行录入、整理。由于该领域中文文献数量太少(3篇),无法建立中文文献的关键词共现矩阵,故仅对英文文献关键词进行提取。对纳入研究的39篇英文文献提取关键词后,继续采用该软件建立关键词共现矩阵,使用Ucinet 6.2绘制关键词共现网络知识图谱,并进行新生儿重症监护领域OLDU共词分析。

结果

自纳入本研究的新生儿重症监护领域OLDU的39篇英文文献中,提取关键词共计18个,最早的文献发表于1999年,并且进行这方面研究文献的数量呈逐年升高趋势。新生儿重症监护领域OLDU英文文献关键词共现网络知识图谱显示,位于图谱中心的是"neonate(新生儿)""off-label drug(超说明书药物)"和"preterm(早产儿)";其次"audit(审查)""antibiotic(抗菌药物)""inhaled nitric oxide(吸入一氧化氮)"也是较为热门关键词。此外,关键词"pharmacokinetics(药物代谢动力学)"的位置虽然偏离核心关键词,但是与关键词"neonate(新生儿)"的联系较为紧密(连线较粗)。

结论

新生儿重症监护领域OLDU相关问题并不少见,国外对该领域的关注时间较长、研究范围覆盖面较广。我国对该领域的研究处于起步阶段,目前需要加强对新生儿重症监护领域OLDU的重视和关注,并开展相关临床试验,以保障新生儿患者用药安全。

Objective

To analyse status quo of literatures on off-label drug use (OLDU) in the field of neonatal intensive care, aiming at discussing the research status and future prospects for OLDU in this field.

Methods

The Chinese National Knowledge Infrastructure (CNKI) databases, Wanfang database and MEDLINE database had been searched using the key words of " neonatal intensive care" and " off-label drug" . And publication time of the literatures are databases construction until June 31, 2018. A total of 42 articles (3 Chinese and 39 English) in accordance with the accepting criteria of this study were included as the research objects. Key words of the included literatures were entered and collated by using Microsoft Office Excel 2016 software. The co-occurrence matrix was established by Excel 2016. Then Ucinet 6.2 was used to plot the knowledge map.

Results

In the 39 English-language literatures related to OLDU in the field of neonatal intensive care, 18 key words were included. The earliest published literature was published in 1999, and the number of related literatures in this field is increasing year by year. The co-word analysis of English literature key words revealed that " neonate" " off-label drug" and " preterm" were the core in the research field of neonatal intensive care unit. Furthermore, " audit" " antibiotic" and " inhaled nitric oxide" were also hot key words. In addition, the position of the key word " pharmacokinetics" was off-center, but it was also closely related to the key word " neonate" .

Conclusions

OLDU is very common in the field of neonatal intensive care. Foreign countries have paid attention to this field for a long time and covered a wide range of research. Eyes are just beginning to be cast on OLDU in neonatal intensive care in China. At present, it is necessary to strengthen the attention and pay more attention to the OLDU in the field of neonatal intensive care. Relevant clinical trials should be carried out to ensure the safety of medication for neonatal patients in neonatal intensive care unit.

图1 39篇新生儿重症监护领域超药品说明书用药相关英文文献发表时间分布柱状图
表1 合并39篇英文文献的同义关键词为本研究设定的关键词对照表
表2 39篇英文文献的18个关键词出现的频次比较(次)
图2 新生儿重症监护领域超药品说明书用药的英文关键词共现网络知识图谱
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