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中华妇幼临床医学杂志(电子版) ›› 2018, Vol. 14 ›› Issue (05) : 608 -611. doi: 10.3877/cma.j.issn.1673-5250.2018.05.019

所属专题: 文献

综述

多胺对人及哺乳动物生殖调控作用
韩阁阁1, 胡艳秋2,()   
  1. 1. 116000 辽宁,大连医科大学
    2. 225000 江苏扬州,苏北人民医院
  • 收稿日期:2018-04-02 修回日期:2018-07-30 出版日期:2018-10-01
  • 通信作者: 胡艳秋

Polyamines regulation on human and mammalian reproduction

Gege Han1, Yanqiu Hu2,()   

  1. 1. Dalian Medical University, Dalian 116000, Liaoning Province, China
    2. Northern Jiangsu People′s Hospital, Yangzhou 225000, Jiangsu Province, China
  • Received:2018-04-02 Revised:2018-07-30 Published:2018-10-01
  • Corresponding author: Yanqiu Hu
  • About author:
    Corresponding author: Hu Yanqiu, Email:
  • Supported by:
    Scientific Research Project of Jiangsu Provincial Commission of Health and Family Planning(QNRC2016347)
引用本文:

韩阁阁, 胡艳秋. 多胺对人及哺乳动物生殖调控作用[J]. 中华妇幼临床医学杂志(电子版), 2018, 14(05): 608-611.

Gege Han, Yanqiu Hu. Polyamines regulation on human and mammalian reproduction[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2018, 14(05): 608-611.

多胺(polyamines)是带有正电荷的脂肪族化合物,通过结合DNA、RNA和蛋白质等,参与人及哺乳动物的基因表达调控、细胞信号传导等。多胺可影响下丘脑-垂体-性腺轴激素的分泌,进而影响生殖细胞质量、黄体形成及胚胎发育,对人及哺乳动物生殖过程发挥调控作用,但是其具体作用机制,迄今尚未阐明。笔者拟就多胺的生物合成,人及哺乳动物体内分布及其来源,对精子发生、卵子形成、囊胚着床及发育作用的最新研究进展进行综述,旨在为多胺用于辅助生殖技术(ART)中,改善妊娠结局提供依据。

Polyamines are positively charged aliphatic compounds, which are involved in regulation of gene expression and cell signal transduction in human and mammalian by binding DNA, RNA and protein. Polyamines can affect the secretion of hypothalamus-pituitary-gonadal axis hormones, and then affect the quality of germ cells, luteal formation and embryonic development, and play a regulatory role in human and mammalian reproductive process, but the specific mechanisms of those effects have not been clarified. This paper focuses on the recent advances in biosynthesis, distribution and origin of polyamines, and the roles of polyamines on spermatogenesis, oogenesis, blastocyst implantation and development. The aim of this study is to provide evidences for the use of polyamines in assisted reproductive techniques (ART) to improve pregnancy outcomes.

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