探讨CO₂激光治疗有症状宫颈糜烂合并高危型人乳头瘤病毒(HR-HPV)感染的有效性。

选择2015年1至12月，在扬州市妇幼保健院采用CO₂激光治疗的宫颈糜烂合并HR-HPV感染，并且伴临床症状或体征的48例宫颈糜烂患者为研究对象。统计学分析轻、中度有症状宫颈糜烂合并HR-HPV感染患者与重度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率，了解48例患者经CO₂激光治疗后的人乳头瘤病毒(HPV)转阴率。

CO₂激光治疗后，27例轻、中度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率为96.3%(26/27)，21例重度有症状宫颈糜烂合并HR-HPV感染患者的治疗有效率为90.5%(19/21)，二者比较，差异无统计学意义(χ²＝0.050，P＝0.823)。48例患者术后3～6个月复查HPV-DNA，其中45例为HPV呈阴性，3例仍然呈阳性，术后HPV转阴率为93.8%(45/48)。

CO₂激光治疗是临床治疗有症状宫颈糜烂合并HR-HPV感染的有效治疗方法。

To investigate the effects of CO₂ laser treatment for cervical erosion patients with high risk human papilloma virus(HR-HPV) infection and clinical manifestations.

From January to December 2015, 48 cervical erosion patients with HR-HPV infection combined with clinical symptoms or signs who received CO₂ laser treatment in Yangzhou Maternal and Child Care Service Centre were chosen as research subjects. The difference of effective rates between cervical erosion level of mild/moderate and severe was compared. Understand the human papilloma virus (HPV) turn negative rate of the 48 patients after treatment.

After CO₂ laser treatment, the treatment effective rate of 27 cases of mild/moderate cervical erosion patients was 96.3% (26/27), the treatment effective rate of 21 cases of severe cervical erosion patients was 90.5%(19/21), there was no significant difference between two effective rates (χ²=0.050, P=0.823). The HPV-DNA recheck results after 3-6 months of operation of 48 patients, 45 cases turned to negative and 3 cases still remained positive. The turn negative rate of HPV was 93.8%(45/48) after operation.

CO₂ laser treatment is an effective method for the treatment of cervical erosion patients with HR-HPV infection combine with clinical manifestations.