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中华妇幼临床医学杂志(电子版) ›› 2011, Vol. 07 ›› Issue (01) : 62 -65. doi: 10.3877/cma.j.issn.1673-5250.2011.01.018

综述

妊娠期肝内胆汁淤积症胎儿宫内缺氧机制的研究进展
何毛毛   
  1. 610041 四川成都,四川大学华西第二医院妇产科
  • 出版日期:2011-02-01

Research Progress of Fetus Hypoxia Mechanism of Intrahepatic Cholestasis of Pregnancy

Mao-mao HE   

  1. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Published:2011-02-01
  • Supported by:
    * Project No.2009SZ0016, supported by Projects in Science & Technology Pillar Program of Sichuan Province
引用本文:

何毛毛. 妊娠期肝内胆汁淤积症胎儿宫内缺氧机制的研究进展[J]. 中华妇幼临床医学杂志(电子版), 2011, 07(01): 62-65.

Mao-mao HE. Research Progress of Fetus Hypoxia Mechanism of Intrahepatic Cholestasis of Pregnancy[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2011, 07(01): 62-65.

妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy, ICP)是发生在妊娠中、晚期的一种妊娠特有并发症,以皮肤瘙痒、胆汁酸升高和肝功能异常为主要临床表现。此妊娠并发症孕产妇预后良好,但可导致胎儿早产、羊水胎粪污染、胎儿宫内窘迫,甚至胎死宫内等严重妊娠结局。因此,研究妊娠期肝内胆汁淤积症胎儿宫内缺氧的机制对围生儿预后至关重要。本文就妊娠期肝内胆汁淤积症胎儿宫内缺氧机制的研究进展,综述如下。

Intrahepatic cholestasis of pregnancy (ICP) is a cholestatic disorder characterized by pruritus with onset in the second or third trimester of pregnancy, elevated serum aminotransferases and bile acid levels, and spontaneous relief of signs and symptoms within two to three weeks after delivery. Maternal prognosis is good, but it increases the risk of preterm delivery, meconium staining of amniotic fluid, fetal distress, and fetal death. This article reviews the mechanism of fetal hypoxia in intrahepatic cholestasis of pregnancy.

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