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中华妇幼临床医学杂志(电子版) ›› 2015, Vol. 11 ›› Issue (06) : 798 -800. doi: 10.3877/cma.j.issn.1673-5250.2015.06.025

所属专题: 文献

综述

妊娠期肝内胆汁淤积症免疫因素的研究进展
孔艳1   
  1. 1. 225001 江苏扬州大学临床医学院妇产科
  • 收稿日期:2015-10-08 修回日期:2015-11-10 出版日期:2015-12-01

Research progress of immune factors in intrahepatic cholestasis of pregnancy

Yan Kong1   

  1. 1. Department of Obstetrics and Gynecology, Clinical Medical College, Yangzhou University, Yangzhou 225001, Jiangsu Province, China
  • Received:2015-10-08 Revised:2015-11-10 Published:2015-12-01
  • About author:
    Corresponding author: Kong Xiang, Email:
引用本文:

孔艳. 妊娠期肝内胆汁淤积症免疫因素的研究进展[J/OL]. 中华妇幼临床医学杂志(电子版), 2015, 11(06): 798-800.

Yan Kong. Research progress of immune factors in intrahepatic cholestasis of pregnancy[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2015, 11(06): 798-800.

妊娠期肝内胆汁淤积症(ICP)是产科较常见疾病,对胎儿具有严重不良影响。ICP病因和发病机制迄今尚未明确,免疫因素被认为参与其发病。辅助性T细胞(Th)中,Th1/Th2免疫平衡向Th1偏移是ICP发病的重要环节。Th17分泌过量白细胞介素(IL)-17,巨噬细胞分泌大量肿瘤坏死因子(TNF)-α,调节性T细胞(Treg)细胞功能及人类白细胞抗原(HLA)表达水平的下调,以及其与其他细胞因子相互作用均可导致其发病。笔者就免疫系统与ICP的发生发展的关系进行综述如下。

Intrahepatic cholestasis of pregnancy(ICP) is a common obstetric disease. It has adverse effects on the fetus. Its etiology and pathogenesis are unclear now. Immune factors are thought to participate in pathogenesis of ICP. In T helper cells (Th), the immune balance of Th1/Th2 shifted towards Th1 is an important part of the pathogenesis of ICP. Th17 secreting excess interleukin(IL)-17, macrophages secreting a lot of tumor necrosis factor (TNF)-α, lower function of regulatory T cells(Treg), lower expression of human leukocyte antigen (HLA) and interacting with other cytokines lead to its pathogenesis. The relationship between the development of ICP and the immune system will be summarized.

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