Clinical effect of bioelectric stimulation on endometrial repair after artificial termination of pregnancy

doi:10.3877/cma.j.issn.1673-5250.2021.01.014

Objective

To explore clinical effects of bioelectric stimulation on endometrial repair after artificial termination of pregnancy.

Methods

From January 2017 to June 2018, a total of 100 patients who underwent artificial termination of pregnancy in Huai′an Women and Children Health Hospital were selected as research subjects. According to the random number table method, they were divided into observation group (n=50, treated with bioelectric stimulation) and control group (n=50, treated with oral drospirenone ethinyl estradiol). The general clinical data, endometrial thickness, uterine spiral artery pulsatility index (PI) and resistance index (RI) were observed before and after treatment. This study complies with the requirements of the Helsinki Declaration of the World Medical Association revised in 2013, and was approved by the Ethics Committee of Huai′an Women and Children Health Hospital (Approval No. 2016008). Informed concent was obtained from each participates.

Results

① There were no significant differences between two groups in the aspects of age, times of artificial termination of pregnancy and body mass index (BMI) (P>0.05). ② After treatment, the endometrial thickness of observation group was (9.8±2.8) mm, which was thicker than that of control group (8.0±2.5) mm, and the difference was statistically significant (t=7.012, P=0.007). In addition, there were significant differences in endometrial thickness before and after treatment of observation group and control group, respectively (t=15.619, 12.952, P<0.001, <0.001). ③ After treatment, PI and RI of uterine spiral artery of observation group were 1.0±0.1 and 0.7±0.1, respectively, which were significantly higher than those of control group (0.9±0.1 and 0.6±0.1, respectively), and the difference between two groups was statistically significant (t=4.106、2.028, P=0.003, 0.016). In addition, there were significant difference in PI and RI of uterine spiral artery before and after treatment of observation group and control group, respectively (observation group: t=3.261, 12.432, P=0.010, <0.001; control group: t=3.065, 10.307, P=0.021, <0.001).

Conclusions

The effect of bioelectric stimulation on endometrial repair was better than that of oral drospiroone ethinylestradiol treatment. Because this study is just a retrospective study, the clinical application value of this technology needs to be confirmed by the results of large sample, multicenter and randomized controlled study.

Key words: Electric stimulation therapy, Drug therapy, Abortion, induced, Endometrium, Comparative effectiveness research, Pregnant women

表1 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者一般临床病例资料比较(±s)

组别	例数	年龄(岁)	人工终止妊娠术史(次)	BMI(kg/m²)
观察组	50	21.8±4.7	3.0±0.7	21.4±1.8
对照组	50	20.5±4.3	2.8±0.7	20.8±1.6
t值		0.617	1.643	1.739
P值		0.542	0.083	0.095

表1 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者一般临床病例资料比较(±s)

组别	例数	年龄(岁)	人工终止妊娠术史(次)	BMI(kg/m²)
观察组	50	21.8±4.7	3.0±0.7	21.4±1.8
对照组	50	20.5±4.3	2.8±0.7	20.8±1.6
t值		0.617	1.643	1.739
P值		0.542	0.083	0.095

表2 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者治疗前、后子宫内膜厚度比较(mm，±s)

组别	例数	治疗前	治疗后	t值	P值
观察组	50	3.8±1.4	9.8±2.8	15.619	<0.001
对照组	50	4.0±1.6	8.0±2.5	12.952	<0.001
t值		1.056	7.012
P值		0.736	0.007

表2 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者治疗前、后子宫内膜厚度比较(mm，±s)

组别	例数	治疗前	治疗后	t值	P值
观察组	50	3.8±1.4	9.8±2.8	15.619	<0.001
对照组	50	4.0±1.6	8.0±2.5	12.952	<0.001
t值		1.056	7.012
P值		0.736	0.007

表3 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者治疗前、后子宫螺旋动脉PI及RI比较(±s)

组别	例数	PI				RI
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
观察组	50	0.8±0.1	1.0±0.1	3.261	0.010	0.6±0.1	0.7±0.1	12.432	<0.001
对照组	50	0.8±0.1	0.9±0.1	3.065	0.021	0.6±0.1	0.6±0.1	10.307	<0.001
t值		2.689	4.106			1.087	2.028
P值		0.055	0.003			0.338	0.016

表3 2组接受人工终止妊娠术后子宫内膜厚度<7 mm患者治疗前、后子宫螺旋动脉PI及RI比较(±s)

组别	例数	PI				RI
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
观察组	50	0.8±0.1	1.0±0.1	3.261	0.010	0.6±0.1	0.7±0.1	12.432	<0.001
对照组	50	0.8±0.1	0.9±0.1	3.065	0.021	0.6±0.1	0.6±0.1	10.307	<0.001
t值		2.689	4.106			1.087	2.028
P值		0.055	0.003			0.338	0.016

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