Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (02): 162 -167. doi: 10.3877/cma.j.issn.1673-5250.2023.02.007

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Current research status and prospect in diagnosis of children with Duchenne muscular dystrophy by high-frequency ultrasound and shear wave elasticity imaging

Kunkun Qiang, Hong Luo()   

  1. Department of Ultrasound, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2022-09-02 Revised:2023-01-30 Published:2023-04-01
  • Corresponding author: Hong Luo
  • Supported by:
    Key Research and Development Support Plan Project of Science and Technology Bureau in Chengdu(2021-YF05-02096-SN)

Duchenne muscular dystrophy (DMD) is a recessive hereditary neuromuscular disease that involved sproximate muscles initially and progressing to distal muscles. The main clinical manifestations of DMD are muscle weakness, muscle atrophy, and eventually complete loss of exercise ability of children with DMD. Ultrasound is an important tool for diagnosing DMD, among which high-frequency ultrasound (HFU) can precisely locate superficial soft tissue structures such as muscles, tendons and peripheral nerves and can obtain parameters such as muscle thickness and cross-section area, which has a high sensitivity. Shear wave elastography (SWE) can quantitatively and dynamically evaluate muscle stiffness in real time and then evaluate changes of muscle mechanical properties in children with DMD. This article intends to elaborate the latest research progress of pathophysiological mechanism, routine clinical diagnosis methods, application status and prospect of HFU and SWE technologies in children with DMD.

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