Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2021, Vol. 17 ›› Issue (05): 510 -515. doi: 10.3877/cma.j.issn.1673-5250.2021.05.003

Forum

Current research status between oral microbiome and common non-oral diseases in children

Lei Yang1,1, Dongqiong Xiao2,2, Yisi Zhong3,3,()   

  • Received:2021-04-11 Revised:2021-09-22 Published:2021-10-01
  • Corresponding author: Yisi Zhong
  • Supported by:
    Basic Appiled Research Project of Science and Technology Department of Sichuan Province(2021YJ0229)

Oral cavity is at the uppermost part of human digestive tract. There are many distinct microenvironments in oral cavity, and oral cavity is the main way for pathogens to enter human body. Compared with adults, the oral microbiome in children changes dynamically with body′s growth, and it is more sensitive to external stimulation. The abnormal changes of oral microbiome in children are closely related to occurrence and development of a variety of diseases. Therefore, non-invasive biological samples can be collected through oral cavity to assist in immediate detection and rapid diagnosis of some diseases for children, and it is of great significance. This article summarizes establishment and characteristics of children′s oral microbiome, focuses on research advances in relationship between oral microbiome and children′s some non-oral diseases in recent years, including asthma, Henoch-Schonlein purpura (HSP), obesity, appendicitis and inflammatory bowel disease (IBD), in order to provide evidences for auxiliary diagnosis of children′s some non-oral diseases.

表1 与儿童哮喘相关的口腔菌群
表2 与过敏性紫癜患儿相关的口腔菌群
表3 与儿童肥胖相关的口腔菌群
表4 与阑尾炎患儿相关的口腔菌群
表5 与炎症性肠病患儿相关的口腔菌群
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