Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2021, Vol. 17 ›› Issue (02): 138 -141. doi: 10.3877/cma.j.issn.1673-5250.2021.02.003

Special Issue:

Forum

Current research status on pathogenesis of endometriosis

Mengshan Liang, Yaokui Zhu()   

  • Received:2021-01-09 Revised:2021-03-07 Published:2021-04-01
  • Corresponding author: Yaokui Zhu
  • Supported by:
    Natural Science Foundation of Guangdong Province(10151063201000058); Research Foundation of Medical Science and Technology of Guangdong Province(A2011344)

Endometriosis (EMS)is a benign disease with malignant behavior, and its pathogenesis has not been explained completely and clearly so far. Latest studies have found that the occurence and development of EMS can be accounted for transfer, implantation and differentiation of endometrial mesenchymal stem cells (eMSC) or bone marrow stem cells (bMSC). At the same time, inflammatory cascade reaction caused by secretion of a variety of inflammatory mediators by immune cells provides a local microenvironment for growth and invasion of endometrium ectopic tissue. In this paper, research progresses on EMS pathogenesis are summarized based on stem cells and immune cells.

[1]
Horne AW, Saunders PTK. Snap shot: endometriosis[J]. Cell, 2019, 179(7): 1677-1677. DOI: 10.1016/j.cell.2019.11.033.
[2]
郎景和,崔恒,戴毅,等.2015年子宫内膜异位症的诊治指南专家解读[J]. 中华妇产科杂志,2017,52(12): 857-861. DOI: 10.3760/cma.j.issn.0529-567x.2017.12.013.
[3]
Cousins FL, O DF, Gargett CE. Endometrial stem/progenitor cells and their role in the pathogenesis of endometriosis[J]. Best Pract Res Clin Obstet Gynaecol, 2018, 20: 27-38. DOI: 10.1016/j.bpobgyn.2018.01.011.
[4]
Xu S, Chan RWS, Ng EHY, et al. Spatial and temporal characterization of endometrial mesenchymal stem-like cells activity during the menstrual cycle[J]. Exp Cell Res, 2017, 350(1): 184-189. DOI: 10.1016/j.yexcr.2016.11.020.
[5]
Barragan F, Irwin JC, Balayan S, et al. Human endometrial fibroblasts derived from mesenchymal progenitors inherit progesterone resistance and acquire an inflammatory phenotype in the endometrial niche in endometriosis[J]. Biol Reprod, 2016, 94(5): 118. DOI: 10.1095/biolreprod.115.136010.
[6]
Baranov VS, Ivaschenko TE, Yarmolinskaya MI. Comparative systems genetics view of endometriosis and uterine leiomyoma: two sides of the same coin?[J].Syst Biol Reprod Med, 2016, 62(2): 93-105.DOI: 10.3109/19396368.2015.1123325.
[7]
Guo SW. Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology[J]. Hum Reprod Update, 2020, 26(3): 423-449.DOI: 10.1093/humupd/dmz047.
[8]
Bulun SE, Yilmaz BD, Sison C, et al. Endometriosis[J]. Endocr Rev, 2019, 40(4): 1048-1079.DOI: 10.1210/er.2018-00242.
[9]
Wang LX, Zhao J, Li Y, et al. Genome-wide analysis of DNA methylation in endometriosis using illumina human methylation 450 K bead chips[J]. Mol Reprod Dev, 2019, 86(5): 491-501. DOI: 10.1002/mrd.23127.
[10]
Tampaki EC, Tampakis A, Kontzoglou K, et al. Commentary: somatic stem cells and their dysfunction in endometriosis[J]. Front Surg, 2017, 4: 37.DOI: 10.3389/fsurg.2017.00037.
[11]
Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis-associated infertility[J]. Obstet Gynecol Clin North Am, 2012, 39(4): 535-549. DOI: 10.1016/j.ogc.2012.10.002.
[12]
Li F, Alderman MH, Tal A, et al. Hematogenous dissemination of mesenchymal stem cells from endometriosis[J]. Stem Cells, 2018, 36(6): 881-890. DOI: 10.1002/stem.2804.
[13]
Koninckx PR, Ussia A, Adamyan L, et al. Pathogenesis of endometriosis: the genetic/epigenetic theory[J]. Fertil Steril, 2019, 111(2): 327-340. DOI: 10.1016/j.fertnstert.2018.10.013.
[14]
O DF, Roskams T, Van den Eynde K, et al. The presence of endometrial cells in peritoneal fluid of women with and without endometriosis[J]. Reprod Sci, 2017, 24(2): 242-251. DOI: 10.1177/1933719116653677.
[15]
Chen P, Mamillapalli R, Habata S, et al. Endometriosis cell proliferation induced by bone marrow mesenchymal stem cells[J]. Reprod Sci, 2021, 28(2): 426-434. DOI: 10.1007/s43032-020-00294-4.
[16]
Du H, Taylor HS. Contribution of bone marrow-derived stem cells to endometrium and endometriosis[J]. Stem Cells, 2007, 25(8): 2082-2086. DOI: 10.1634/stemcells.2006-0828.
[17]
Zondervan KT, Becker CM, Koga K, et al. Endometriosis[J].Nat Rev Dis Primers, 2018, 4(1): 9. DOI: 10.1038/s41572-018-0008-5.
[18]
Moridid I, Mamillapalli R, Cosar E, et al. Bone marrow stem cell chemotactic activity is induced by elevated CXCL12 in endometriosis[J]. Roprod Sci, 2016, 24(4):526-533.DOI: 10.1177/1933719116672587.
[19]
AlAshqar A, Reschke L, Kirschen GW, et al. Role of inflammation in benign gynecologic disorders: from pathogenesis to novel therapies[J]. Biol Reprod, 2021: ioab054.DOI: 10.1093/biolre/ioab054.
[21]
Ahn SH, Khalaj K, Young SL, et al. Immune-inflammation gene signatures in endometriosis patients[J].Fertil Steril, 2016, 106(6): 1420-1431.e7. DOI: 10.1016/j.fertnstert.2016.07.005.
[22]
Chen Y, Wang K, Xu Y, et al. Alteration of myeloid-derived suppressor cells, chronic inflammatory cytokines, and exosomal miRNA contribute to the peritoneal immune disorder of patients with endometriosis[J].Reprod Sci, 2019, 26(8): 1130-1138. DOI: 10.1177/1933719118808923.
[23]
Aksak T, Gümürdülü D, Cetin MT, et al. Expression of monocyte chemotactic protein 2 and tumor necrosis factor alpha in human normal endometrium and endometriotic tissues[J].J Gynecol Obstet Hum Reprod, 2021, 50(5): 101971. DOI: 10.1016/j.jogoh.2020.101971.
[24]
Guo SW, Du YB, Liu X. Platelet-derived TGF-β1 mediates the down-modulation of NKG2D expression and may be responsible for impaired natural killer (NK) cytotoxicity in women with endometriosis[J]. Hum Reprod, 2016, 31(7): 1462-1474. DOI: 10.1093/humrep/dew057.
[25]
Yu JJ, Sun HT, Zhang ZF, et al. IL15 promotes growth and invasion of endometrial stromal cells and inhibits killing activity of NK cells in endometriosis[J]. Reproduction, 2016, 152(2): 151-160. DOI: 10.1530/REP-16-0089.
[26]
Yang HL, Zhou WJ, Chang KK, et al. The crosstalk between endometrial stromal cells and macrophages impairs cytotoxicity of NK cells in endometriosis by secreting IL-10 and TGF-beta[J]. Reproduction, 2017, 154(6): 815-825. DOI: 10.1530/REP-17-0342.
[27]
王卡娜,郄明蓉. 辅助性T细胞17及调节性T细胞比例失衡与子宫内膜异位症研究现状[J/CD]. 中华妇幼临床医学杂志(电子版),2019,15 (1): 2-7. DOI: 10.3877/cma.j.issn.1673-5250.2019.01.001.
[28]
Shan J, Ni Z, Cheng W, et al. Gut microbiota imbalance and its correlations with hormone and inflammatory factors in patients with stage 3/4 endometriosis[J]. Arch Gynecol Obstet, 2021. DOI: 10.1007/s00404-021-06057-z..
[29]
Hou XX, Wang XQ, Zhou WJ, et al. Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu[J]. Commun Biol, 2021, 4(1): 499. DOI: 10.1038/s42003-021-02018-z.
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