Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (05): 519 -526. doi: 10.3877/cma.j.issn.1673-5250.2020.05.004

Special Issue:

Forum

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases

Min Jiang1, Yanyan Xie2, Yanjiao Yao2, Dan Lu1,()   

  1. 1. Clinical Medical College, Yangzhou University, Department of Obstetrics and Gynecology, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China
    2. Dalian Medical University, Dalian 116044, Liaoning Province, China
  • Received:2020-01-03 Revised:2020-09-01 Published:2020-10-01
  • Corresponding author: Dan Lu
  • Supported by:
    Scientific Research Project of Maternal and Child Health in Jiangsu Province(F201663); Project of Science and Technology Plan in Yangzhou City(YZ2017075)

Notch gene was originally a gene discovered by Morgan in drosophila in 1917. Part of the gene′s loss of function may cause a gap in the edges of wings of drosophila, so the gene was named as Notch. Studies have found that Notch signaling pathway is a highly conserved type of signaling pathway in evolution process of invertebrates and vertebrates. In recent years, Notch signaling pathway has become one of the research hotspots in many fields, such as auxanology, cell biology, immunology, hematology and oncology. And it participates in the occurrence and development of many diseases shows that latest research on Notch signaling pathway and pregnancy-related diseases shows that the Notch signaling pathway can affect differentiation, proliferation, infiltration and migration of early cytotrophoblasts (CTB), participate in embryo implantation, placenta and its blood vessel formation, play an important role in the blood circulation of placenta, and then it has a certain impact on the occurrence and development of pathological pregnancy, such as preeclampsia, unexplained recurrent spontaneous abortion (URSA) and fetal growth restriction (FGR) and so on. This article focuses on the latest research progress of Notch signaling pathway in pregnancy-related diseases.

[1]
张悦,马蕾,薛海波,等. Notch信号通路调控调节性T细胞分化与功能的研究进展[J]. 现代免疫学,2018, 38(2): 162-165.
[2]
Steinbuck MP, Arakcheeva K, Winandy S. Novel TCR-mediated mechanisms of notch activation and signaling [J]. J Immunol, 2018, 200(3): 997-1007. DOI: 10.4049/jimmunol.1700070.
[3]
任文汇,王春梅,李楠. Notch信号通路在B细胞分化发育以及B细胞淋巴瘤中作用的研究进展[J]. 中国肿瘤生物治疗杂志,2016, 23(2): 282-286. DOI: 10.3872/j.issn.1007-385X.2016.02.021.
[4]
Nakano N, Nishiyama C, Yagita H, et al. Notch signaling enhances FcεRI-mediated cytokine production by mast cells through direct and indirect mechanisms [J]. J Immunol, 2015, 194(9): 4535-4544. DOI: 10.4049/jimmunol.1301850.
[5]
Cemgil Arikan D, Aral M, Coskun A, et al. Plasma IL-4, IL-8, IL-12, interferon-î3 and CRP levels in pregnant women with preeclampsia, and their relation with severity of disease and fetal birth weight [J]. J Matern Fetal Neonatal Med, 2012, 25(9): 1569-1573. 10.3109/14767058.2011.648233.
[6]
Campese AF, Grazioli P, de Cesaris P, et al. Mouse sertoli cells sustain de novo generation of regulatory T cells by triggering the notch pathway through soluble JAGGED1 [J]. Biol Reprod, 2014, 90(3): 53. DOI: 10.1095/biolreprod.113.113803.
[7]
Le Friec G, Sheppard D, Whiteman P, et al. The CD46-Jagged1 interaction is critical for human TH1 immunity [J]. Nat Immunol, 2012, 13(12): 1213-1221. DOI: 10.1038/ni.2454.
[8]
Dongre A, Surampudi L, Lawlor RG, et al. Non-canonical notch signaling drives activation and differentiation of peripheral CD4 T cells [J]. Front Immunol, 2014, 5: 54. DOI: 10.1038/ni.2454.
[9]
谢东杰,王爱迪,吴晶魁,等. Notch信号通路对CD4T细胞分化及功能调控的研究进展[J]. 免疫学杂志,2017, 33(12): 1100-1104. DOI: 10.13431/j.cnki.immunol.j.20170191.
[10]
Roderick JE, Gonzalezperez G, Kuksin CA, et al. Therapeutic targeting of Notch signaling ameliorates immune-mediated bone marrow failure of aplastic anemia [J]. J Exp Med, 2013, 210(7): 1311-1329. DOI: 10.1084/jem.20112615.
[11]
Verma NK, Fazil MH, Ong ST, et al. LFA-1/ICAM-1 ligation in human T cells promotes Th1 polarization through a GSK3β signaling-dependent Notch pathway [J]. J Immunol, 2016, 197(1): 108-118. DOI: 10.4049/jimmunol.1501264.
[12]
Jiang S, Han S, Chen J, et al. Inhibition effect of blunting Notch signaling on food allergy through improving TH1/TH2 balance in mice [J]. Ann Allergy Asthma Immunol, 2017, 18(1): 94-102. DOI: 10.1016/j.anai.2016.10.024.
[13]
陈振振,贡欣. Th17/Treg细胞免疫失衡与妊娠相关疾病的研究进展[J]. 医学综述,2017, 23(17): 3359-3362. DOI: 10.3969/j.issn.1006-2084.2017.17.007.
[14]
黄千贻,李慕军. Treg/Th17平衡与复发性流产[J]. 中国免疫学杂志,2015, 31(10): 1422-1425. DOI: 10.3969/j.issn.1000-484X.2015.10.029.
[15]
Keerthivasan S, Suleiman R, Lawlor R, et al. Notch signaling regulates mouse and human Th17 differentiation [J]. J Immunol, 2011, 187(2): 692-701. DOI: 10.4049/jimmunol.1003658.
[16]
Wongchana W, Lawlor RG, Osborne BA, et al. Impact of Notch1 deletion in macrophages on pro-inflammatory cytokine production and the outcome of experimental autoimmune encephalomyelitis [J]. J Immunol, 2015, 195(11): 5337. DOI: 10.4049/jimmunol.1401770.
[17]
Rong H, Shen H, Xu Y, et al. Notch signaling suppresses regulatory T cell function in murine experimental autoimmune uveitis [J]. Immunology, 2016, 149(4): 447-459. DOI: 10.1111/imm.12663.
[18]
Yao Y, Song J, Wang W, et al. Decidual vascular endothelial cells promote maternal-fetal immune tolerance by inducing regulatory T cells through canonical Notch1 signaling [J]. Immunol Cell Biol, 2017, 95(4): 416. DOI: 10.1038/icb.2017.12.
[19]
王晨曦,林其德,戴良图,等. Notch1蛋白在正常妊娠早中晚期胎盘绒毛中的表达变化及其意义[J]. 现代妇产科进展,2013, 22(3): 199-201. DOI: 10.13431/j.cnki.immunol.j.20170191.
[20]
Cuman C, Menkhorst EM, Rombauts LJ, et al. Preimplantation human blastocysts release factors that differentially alter human endometrial epithelial cell adhesion and gene expression relative to IVF success [J]. Hum Reprod, 2013, 28(5): 1161-1171. DOI: 10.1093/humrep/det058.
[21]
黄静,孙大光,张益,等. Notch1在先兆子痫胎盘组织中的表达[J]. 重庆医科大学学报,2013, 38(10): 1159-1162. DOI: 10.11699/cyxb20131014.
[22]
赵先兰,陶雅,王永红,等. Notch信号通路配体Jagged1、Dll4在子痫前期胎盘组织中的表达[J]. 郑州大学学报(医学版), 2017, 52(3): 359-362. DOI: 10.13705/j.issn.1671-6825.2017.03.029.
[23]
李巧云,吕冉冉,李广太,等. Notch1及其配体DLL4在子痫前期患者胎盘组织中的表达[J]. 中华妇产科杂志,2013, 48(11): 862-864. DOI: 10.3760/cma.j.issn.0529-567x.2013.11.014.
[24]
洪日,戚基萍,吴鹤. Notch信号通路在血管生成方面的作用[J]. 医学综述,2017, 23(21): 4189-4193. DOI: 10.3969/j.issn.1006-2084.2017.21.006.
[25]
Maynard S, Epstein FH, Karumanchi SA. Preeclampsia and angiogenic imbalance [J]. Ann Rev Med, 2008, 59: 61. DOI: 10.1146/annurev.med.59.110106.214058.
[26]
Velicky P, Haider S, Otti GR, et al. Notch-dependent RBP-Jκ inhibits proliferation of human cytotrophoblasts and their differentiation into extravillous trophoblasts [J]. Mol Hum Reprod, 2014, 20(8): 756-766. DOI: 10.1093/molehr/gau038.
[27]
Tang L, Gao C, Gao L, et al. Expression profile of micro-RNAs and functional annotation analysis of their targets in human chorionic villi from early recurrent miscarriage [J]. Gene, 2016, 576(1): 366-371. DOI: 10.1016/j.gene.2015.10.047.
[28]
刘卓,李益亮,张志,等. Notch4受体对血管新生的影响[J]. 中医正骨,2016, 28(6): 56-58.
[29]
Moya IM, Umans L, Maas E, et al. Stalk cell phenotype depends on integration of Notch and Smad1/5 signaling cascades [J]. Dev Cell, 2012, 22(3): 501-514. DOI: 10.1016/j.devcel.2012.01.007.
[30]
谢幸,苟文丽. 妇产科学[M]. 8版. 北京:人民卫生出版社,2013: 64-65.
[31]
赵先兰,王永红,刘彩. Notch信号通路配体Jagged1在子痫前期胎盘组织中的表达及其与胎盘血管形成的关系[J]. 中华妇产科杂志,2016, 51(9): 693-696. DOI: 10.3760/cma.j.issn.0529-567x.2016.09.011.
[32]
赵明智,牛甜甜,李明清,等. 调节性T细胞和Notch1信号通路在原因不明复发性自然流产中的作用[J]. 中华生殖与避孕杂志,2017, 37(6): 469-473. DOI: 10.3760/cma.j.issn.2096-2916.2017.06.009.
[33]
印永祥,韩晓枫,赵益明,等. 原因不明复发性流产中CD4 Notch1 T细胞与IL-10的相关性分析[J]. 标记免疫分析与临床,2010, 17(3): 157-160. DOI: 10.3969/j.issn.1006-1703.2010.03.009.
[34]
Fang Y, Yu S, Ma Y, et al. Association of Dll4/notch and HIF-1a-VEGF signaling in the angiogenesis of missed abortion [J]. PLoS One, 2013, 8(8): e70667. DOI: 10.1371/journal.pone.0070667.
[35]
Nanjo S, Matsushita A, Yahata T, et al. Expression of Notch signaling in placental tissues with preeclampsia (PE) and/or fetal growth restriction (FGR) [J]. Placenta, 2016, 46: 107-108. DOI: 10.1016/j.placenta.2016.08.022.
[36]
Sahin Z, Acar N, Ozbey O, et al. Distribution of Notch family proteins in intrauterine growth restriction and hypertension complicated human term placentas [J]. Acta Histochem, 2011, 113(3): 270-276. DOI: 10.1016/j.acthis.2009.10.006.
[37]
Gundogan F, Bedoya A, Gilligan J, et al. SI-RNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth [J]. Pathol Res Pract, 2011, 207(9): 545-553. DOI: 10.1016/j.prp.2011.06.001.
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