Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2020, Vol. 16 ›› Issue (05): 519 -526. doi: 10.3877/cma.j.issn.1673-5250.2020.05.004

Special Issue:

Forum

Current research status of Notch signaling pathway and the occurrence and development of pregnancy-related diseases

Min Jiang1, Yanyan Xie2, Yanjiao Yao2, Dan Lu1,()   

  1. 1. Clinical Medical College, Yangzhou University, Department of Obstetrics and Gynecology, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China
    2. Dalian Medical University, Dalian 116044, Liaoning Province, China
  • Received:2020-01-03 Revised:2020-09-01 Published:2020-10-01
  • Corresponding author: Dan Lu
  • Supported by:
    Scientific Research Project of Maternal and Child Health in Jiangsu Province(F201663); Project of Science and Technology Plan in Yangzhou City(YZ2017075)

Notch gene was originally a gene discovered by Morgan in drosophila in 1917. Part of the gene′s loss of function may cause a gap in the edges of wings of drosophila, so the gene was named as Notch. Studies have found that Notch signaling pathway is a highly conserved type of signaling pathway in evolution process of invertebrates and vertebrates. In recent years, Notch signaling pathway has become one of the research hotspots in many fields, such as auxanology, cell biology, immunology, hematology and oncology. And it participates in the occurrence and development of many diseases shows that latest research on Notch signaling pathway and pregnancy-related diseases shows that the Notch signaling pathway can affect differentiation, proliferation, infiltration and migration of early cytotrophoblasts (CTB), participate in embryo implantation, placenta and its blood vessel formation, play an important role in the blood circulation of placenta, and then it has a certain impact on the occurrence and development of pathological pregnancy, such as preeclampsia, unexplained recurrent spontaneous abortion (URSA) and fetal growth restriction (FGR) and so on. This article focuses on the latest research progress of Notch signaling pathway in pregnancy-related diseases.

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