Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (04): 472 -475. doi: 10.3877/cma.j.issn.1673-5250.2019.04.020

Special Issue:

Review

Hyperprolactinemia and menstrual disorder caused by antipsychotics

Xiaolin You1, Cong Xie1   

  1. 1. Department of Obstetrics and Gynecology, The Affiliated Hospital, School of Medicine, USETC Chengdu Women′s & Children′s Central Hospital, Chengdu 610041, Sichuan Province, China
  • Received:2019-01-10 Revised:2019-07-16 Published:2019-08-01
  • About author:
    Corresponding author: Gan Xiaoqin, Email:
  • Supported by:
    Program of Health and Family Planning Commission of Sichuan Province(17PJ412)

Antipsychotics (APS) can be divided into typical and atypical APS. Hyperprolactinemia (HPRL) is characterized by an abnormal increase in prolactin level of peripheral blood circulation. All typical APS and atypical APS risperidone can lead to the serum prolactin level of women with mental illness significantly higher than normal value. While most atypical APS only result in transient and slightly increase of serum prolactin level or even do not lead to the increase of serum prolactin level. HPRL caused by APS is one of the main reasons for menstrual disorders and amenorrhea in women with mental illness. The treatments of HPRL, menstrual disorders and amenorrhea caused by APS are mainly to reduce level of prolactin. The incidences of HPRL and menstrual disorders caused by different APS are different. Accurate clinical evaluation and management of HPRL can improve the quality of life and compliance of female psychiatric patients. This review expounds the treatment of adverse reactions HPRL and menstrual disorders caused by APS in treatment of female psychiatric patients, in order to provide reference for clinical reduction of adverse reactions in female psychiatric patients.

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