Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (01): 109 -115. doi: 10.3877/cma.j.issn.1673-5250.2019.01.019

Special Issue:

Review

Research progress of relationship between CXC chemokine ligand 3 and related diseases

Hui Wang1, Rong Zhou1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-11-02 Revised:2019-01-11 Published:2019-02-01
  • Corresponding author: Rong Zhou
  • About author:
    Corresponding author: Zhou Rong, Email:
  • Supported by:
    National Natural Science Foundation of China(81571465, 81871175); Key Research and Development Project of Science and Technology Department of Sichuan Province(2017FZ0067)

CXC chemokine ligand (CXCL)3 is one of low relative molecular mass bioactive proteins, secreted by various kinds of cells. CXCL3 plays a pivotal role in the occurrence and development of pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders which may be associated with its participation in the regulation of cell migration, cell invasion, vasculogenesis and so on by recruiting and activating different kinds of cells which express CXC chemokine receptor (CXCR)1/2. Blocking CXCL3 or CXCR1/2 signal transduction pathways could inhibit such pathophysiological processes as cell migration, cell invasion, angiogenesis, tumorigenesis and fibration and may be the potential targets in the prevention and treatment of multiple diseases. Therefore, this paper reviews the latest research progresses of the relationship between CXCL3 and pregnancy-associated diseases, tumors, cardiovascular diseases, and lung disorders, with the aim to reveal the concrete functions of CXCL3 in the pathogenesis of these disorders and to provide a basis for adopting new diagnosis strategies and molecular targeted therapy for these diseases.

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