Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (01): 103 -108. doi: 10.3877/cma.j.issn.1673-5250.2019.01.018

Special Issue:

Review

YAP/TAZ-mediated regulation mechanism in cardiac development and pathologic remodeling

Peng Yue1, Yimin Hua1, Kaiyu Zhou1, Yifei Li1, Gang Wu1,()   

  1. 1. Department of Pediatrics, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-09-07 Revised:2019-01-11 Published:2019-02-01
  • Corresponding author: Gang Wu
  • About author:
    Corresponding author: Wu Gang, Email:
  • Supported by:
    National Natural Science Foundation of China(81570369, 81571515, 81700360); Program for Changjiang Scholars and Innovative Research Team(IRT0935); Science and Technology Pillar Program of Science and Technology Department of Sichuan Province(2016SZ0056)

As an organ that is extremely sensitive to mechanical stimulation, mechanical stress stimulation is of great significance in the process of cardiac development and cardiac pathological remodeling. With the deepening of research in recent years, the mechanical signal transmission and related regulatory mechanisms have attracted more and more attention. YAP/TAZ, as a pair of newly clarified co-transcriptional factors, links the regulation of the heart by intracellular and external stimulation. Previous studies showed that YAP/TAZ and related Hippo signaling pathway are involved in the genesis and proliferation of myocardial cells, as well as in cardiac pathological remodeling and various pathological processes. This article reviews YAP/TAZ-mediated regulatory mechanisms in cardiac development and cardiac pathological remodeling.

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