Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2024, Vol. 20 ›› Issue (04): 468 -366. doi: 10.3877/cma.j.issn.1673-5250.2024.04.015

Review

Pathogenesis and innovative treatment of congenital abdominal wall defects in children

Shamuxiding Nafeisha1, Kaisaierjiang Aikeremu2, Yaqi Wang1, Wanfu Li1,()   

  1. 1.Department of Pediatric Surgery,The First Teaching Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China
    2.Department of Pediateic Internal Medicine,The First Teaching Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang Uygur Autonomous Region,China
  • Received:2024-01-28 Revised:2024-07-07 Published:2024-08-01
  • Corresponding author: Wanfu Li

Congenital abdominal wall defects (CAWD)are defects in the development of the abdominal wall at birth,resulting in the formation of defects in the abdominal muscles,skin and other tissues on the abdominal surface,the most common of which are gastroschisis and omphalocele.The causes of CAWD are not fully understood,but research suggests that genetic variations,environmental and nutritional factors may be involved.With advances in human science and technology,prenatal screening and molecular medical research have made it possible to diagnose and treat CAWD child early.In recent years,the incidence of CAWD has gradually increased worldwide,and it will have a serious impact on the life of patients,even life-threatening.At present,the main treatment methods for CAWD are surgical repair of defects,and the therapeutic effect is closely related to the size of the defect and the timing of surgery.With the development of genetic testing technology,the pathogenesis of CAWD has been gradually clarified and have begun to try to improve the quality of life of patients through gene therapy.The author intends to review the latest research progress of embryological background,molecular mechanism,environmental and other influencing factors,innovative treatments,and the prenatal screening and public health management strategies of CAWD,in order to provide reference for the research and treatment of related diseases.

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