Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2019, Vol. 15 ›› Issue (01): 2 -7. doi: 10.3877/cma.j.issn.1673-5250.2019.01.001

Special Issue:

Editorial

Current status of relationship between helper T cell 17/regulatory T cell imbalance and endometriosis

Kana Wang1, Mingrong Qie1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2018-09-29 Revised:2018-12-22 Published:2019-02-01
  • Corresponding author: Mingrong Qie
  • About author:
    Corresponding author: Qie Mingrong, Email:
  • Supported by:
    Scientific Research Project of Health and Family Planning Commission of Sichuan Province(17PJ236)

Endometriosis (EMs) is a common disease that seriously perplex the women of childbearing age at present. Because of its complicated pathogenesis, unknown etiology and characteristics of easy implantation and recurrence similar to tumor, there is still no definite diagnosis and treatment strategies for EMs. Recent studies have found that EMs is an autoimmune disease and closely related to T cell immunity. The helper T cell (Th) 17 and regulatory T cell (Treg) are two important subtypes of CD4+ T cells. The imbalance of Th17/Treg and imntraperitoneal environment affected by the imbalance of two cells proportion are related to the occurrence and degree of EMs, and also related to infertility of EMs. In this article, we focus on the latest research status of Th17/Treg and immune-internal environment imbalance in EMs.

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