Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (03): 249 -255. doi: 10.3877/cma.j.issn.1673-5250.2018.03.001

Special Issue:

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Research status on clinical problems of rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn

Xue Ao1, Shiqiao Tan1, Haiyan Yu1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2017-11-10 Revised:2018-02-22 Published:2018-06-01
  • Corresponding author: Haiyan Yu
  • About author:
    Corresponding author: Yu Haiyan, Email:

Rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn (Rh-HDFN) is one of the most common causes of passive immune hemolytic anemia in fetuses or neonates. Rh-HDFN is critically ill, which can cause severe fetal anemia, edema, heart failure, stillbirth and neonatal kernicterus, death. Survival newborns with Rh-HDFN may suffer mental retardation, motor disorders and other neurological sequelae. Early diagnosis of Rh-HDFN and timely treatment are closely related to the prognosis of fetus and newborn, which has attracted more and more clinical attention. This article focuses on related clinical issues and the latest research advance in Rh-HDFN.

[1]
Shao CP, Mass JH, Su YQ, et al. Molecular background of Rh D-positive, D-negative, D(el) and weak D phenotypes in Chinese[J]. Vox Sang, 2002, 83(2): 156-161.
[2]
Moise KJ Jr, Argoti PS. Management and prevention of red cell alloimmunization in pregnancy: a systematic review[J]. Obstet Gynecol, 2012, 120(5): 1132-1139.
[3]
邵超鹏,秦建江,孙国栋,等. Rh阳性个体RHD杂合性分析[J]. 中华医学遗传学杂志,2011, 28(1): 29-32.
[4]
Achargui S, Benchemsi N. A quantitative determination of IgG anti-D subclasses by Elisa in hemolytic disease of the newborn[J]. Transfus Clin Biol, 2003, 10(4): 284-291.
[5]
American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 75: management of alloimmunization during pregnancy[J]. Obstet Gynecol, 2006, 108(2): 457-464.
[6]
韩梅宁,马兆霞,张明刚. 126例Rh阴性妇女D抗原刺激后血清抗体分析[J]. 现代检验医学杂志,2009, 24(2): 125-127.
[7]
苏奶助,沈雨青,龚君顺,等. 厦门地区RhD阴性孕产妇血清学表型及不规则抗体监测的研究[J]. 临床血液学杂志,2016, 29(3): 471-473.
[8]
Rubod C, Deruelle P, Le Goueff F, et al. Long-term prognosis for infants after massive fetomaternal hemorrhage[J]. Obstet Gynecol, 2007, 110(2 Pt 1): 256-260.
[9]
Kulinska R. Haemolytic disease of the fetus and newborn/HDFN/timing in pregnant women and prophylaxis[J]. Akush Ginekol (Sofiia), 2014, 53(2): 58-63.
[10]
Shao CP, Xu H, Xu Q, et al. Antenatal Rh prophylaxis is unnecessary for " Asia type" DEL women[J]. Transfus Clin Biol, 2010, 17(4): 260-264.
[11]
Wang M, Wang BL, Xu W, et al. Anti-D alloimmunisation in pregnant women with DEL phenotype in China[J]. Transfus Med, 2015, 25(3): 163-169.
[12]
Kapur R, Della Valle L, Sonneved M, et al. Low anti-RhD IgG-Fc-fucosylation in pregnancy: a new variable predicting severity in haemolytic disease of the fetus and newborn[J]. Br J Haematol, 2014, 166(6): 936-945.
[13]
危燕芬,严康峰,汪丽娟,等. 单核单层实验在Rh系统新生儿溶血病中的应用[J]. 国际检验医学杂志,2008, 29(6): 496-497, 500.
[14]
Mari G, Norton ME, Stone J. et al. Society for Maternal-Fetal Medicine (SMFM) Clinical Guideline #8: the fetus at risk for anemia-diagnosis and management[J]. Am J Obstet Gynecol, 2015, 212(6): 697-710.
[15]
Mari G, Deter RL, Carpenter RL, et al. Non-invasive diagnosis by Doppler ultrasonography of fetal anemia due to maternal red-cell alloimmunization. Collaborative Group for Doppler Assessment of the Blood Velocity in Anemic Fetuses[J]. N Engl J Med, 2000, 342(1): 9-14.
[16]
Maisonneuve E, Jayot A, Friszer S, et al. Accuracy of middle cerebral artery doppler assessment between 34 and 37 weeks in fetuses with red cell alloimmunization[J]. Fetal Diagn Ther, 2017, 42(3): 225-231.
[17]
Avent ND, Reid ME. The Rh blood group system: a review[J]. Blood, 2000, 95(2): 375-387.
[18]
赵黎,黄醒华. 孕妇输血史与围产儿Rh溶血病的关系[J]. 中华妇产科杂志,1999, 34(4): 45-46.
[19]
De Haas M, Thurik FF, van der Ploeg CP, et al. Sensitivity of fetal RhD screening for safe guidance of targeted anti-D immunoglobulin prophylaxis: prospective cohort study of a nationwide programme in the netherlands[J]. BMJ, 2016, 355(3): i5789.
[20]
Mackie FL, Hemming K, Allen S, et al. The accuracy of cell-free fetal DNA-based non-invasive prenatal testing in singleton pregnancies: a systematic review and bivariate Meta-analysis[J]. BJOG, 2017, 124(1): 32-46.
[21]
Soothill PW, Finning K, Latham T, et al. Use of cffDNA to avoid administration of anti-D to pregnant women when the fetus is RhD-negative: implementation in the NHS[J]. BJOG, 2015, 122(12): 1682-1686.
[22]
Fung Kee Fung K, Eason E, Crane J, et al. Prevention of Rh alloimmunization[J]. J Obstet Gynaecol Can, 2003, 25(9): 765-773.
[23]
Qureshi H, Massey E, Kirwan D, et al. BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn[J]. Transfus Med, 2014, 24(1): 8-20.
[24]
Delaney M, Matthews DC. Hemolytic disease of the fetus and newborn: managing the mother, fetus, and newborn[J]. Hematology Am Soc Hematol Educ Program, 2015, 2015: 146-151.
[25]
Harrod KS, Hanson L, Vandevusse L, et al. Rh negative status and isoimmunization update: a case-based approach to care[J]. J Perinat Neonatal Nurs, 2003, 17(3): 166-178.
[26]
Lindenburg IT, van Kamp IL, van Zwet EW, et al. Increased perinatal loss after intrauterine transfusion for alloimmune anaemia before 20 weeks of gestation[J]. BJOG, 2013, 120(7): 847-852.
[27]
Papantoniou N, Sifakis S, Antsaklis A. Therapeutic management of fetal anemia: review of standard practice and alternative treatment options[J]. J Perinat Med, 2013, 41(1): 71-82.
[28]
van Klink JM, van Veen SJ, Smits-Wintjens VE, et al. Immunoglobulins in neonates with rhesus hemolytic disease of the fetus and newborn:long-term outecome in a randomized trial[J]. Fetal Diagn Ther, 2016, 39(3): 209-313.
[29]
Louis D, More K, Oberoi S, et al. Intravenous immunoglobulin in isoimmune haemolytic disease of newborn: an updated systematic review and Meta-analysis[J]. Arch Dis Child Fetal Neonatal Ed, 2014, 99(4): 325-331.
[30]
Scheier M, Hernandez-Andrade E, Fonseca EB, et al. Prediction of severe fetal anemia in red blood cell alloimmunization after previous intrauterine transfusions[J]. Am J Obstet Gynecol, 2006, 195(6): 1550-1556.
[31]
Payam Khaja Pasha R, Shokri F. Immunologic basis and immunoprophylaxis of Rh(D) induced hemolytic disease of the newborn(HDN)[J]. Iran J Immunol, 2008, 5(4): 181-189.
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