Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2018, Vol. 14 ›› Issue (03): 249 -255. doi: 10.3877/cma.j.issn.1673-5250.2018.03.001

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Research status on clinical problems of rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn

Xue Ao1, Shiqiao Tan1, Haiyan Yu1,()   

  1. 1. Department of Obstetrics and Gynecology, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
  • Received:2017-11-10 Revised:2018-02-22 Published:2018-06-01
  • Corresponding author: Haiyan Yu
  • About author:
    Corresponding author: Yu Haiyan, Email:

Rhesus maternal-fetal blood group incompatibility hemolytic disease of fetus and newborn (Rh-HDFN) is one of the most common causes of passive immune hemolytic anemia in fetuses or neonates. Rh-HDFN is critically ill, which can cause severe fetal anemia, edema, heart failure, stillbirth and neonatal kernicterus, death. Survival newborns with Rh-HDFN may suffer mental retardation, motor disorders and other neurological sequelae. Early diagnosis of Rh-HDFN and timely treatment are closely related to the prognosis of fetus and newborn, which has attracted more and more clinical attention. This article focuses on related clinical issues and the latest research advance in Rh-HDFN.

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