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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2017, Vol. 13 ›› Issue (03): 332 -336. doi: 10.3877/cma.j.issn.1673-5250.2017.03.016

Special Issue: ；

Original Article

CO2 laser treatment for cervical erosion patients with high risk human papilloma virus infection and clinical symptoms

Yuanyuan Li1, Xueli Li2, Xiaomei Zhang2,†()   

  1. 1. Department of Cervix, Yangzhou Maternal and Child Care Service Centre, Yangzhou 225002, Jiangsu Province, China
    2. Clinical Medical School, Yangzhou University/Reproductive Medicine Center, Northern Jiangsu People′s Hospital, Yangzhou 225001, Jiangsu Province, China
  • Received:2017-02-10 Revised:2017-05-05 Published:2017-06-01
  • Corresponding author: Xiaomei Zhang
  • About author:
    Corresponding author: Zhang Xiaomei, Email:
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Objective

To investigate the effects of CO2 laser treatment for cervical erosion patients with high risk human papilloma virus(HR-HPV) infection and clinical manifestations.

Methods

From January to December 2015, 48 cervical erosion patients with HR-HPV infection combined with clinical symptoms or signs who received CO2 laser treatment in Yangzhou Maternal and Child Care Service Centre were chosen as research subjects. The difference of effective rates between cervical erosion level of mild/moderate and severe was compared. Understand the human papilloma virus (HPV) turn negative rate of the 48 patients after treatment.

Results

After CO2 laser treatment, the treatment effective rate of 27 cases of mild/moderate cervical erosion patients was 96.3% (26/27), the treatment effective rate of 21 cases of severe cervical erosion patients was 90.5%(19/21), there was no significant difference between two effective rates (χ2=0.050, P=0.823). The HPV-DNA recheck results after 3-6 months of operation of 48 patients, 45 cases turned to negative and 3 cases still remained positive. The turn negative rate of HPV was 93.8%(45/48) after operation.

Conclusions

CO2 laser treatment is an effective method for the treatment of cervical erosion patients with HR-HPV infection combine with clinical manifestations.

Key words: Carbon dioxide, Laser therapy, Papillomaviridae, Uterine cervical erosion, Female
[1]
Zou R, Xie W, Wang H, et al. Establishment and application of a method for high-risk human papillomavirus genotyping in cervical cancer tissue[J]. Clin Lab, 2016, 62(6): 1075-1085.
[2]
Tezcan S, Ozgur D, Ulger M, et al. Human papillomavirus genotype distribution and E6/E7 oncogene expression in Turkish women with cervical cytological findings[J]. Asian Pac J Cancer Prev, 2014, 15(9): 3997-4003.
[3]
Liu Y, Zhang C, Gao W, et al. Genome-wide profiling of the human papillomavirus DNA integration in cervical intraepithelial neoplasia and normal cervical epithelium by HPV capture technology[J]. Sci Rep, 2016, 6: 35427.
[4]
Wardak S. Human Papillomavirus (HPV) and cervical cancer[J]. Med Dosw Mikrobiol, 2016, 68(1): 73-84.
[5]
Li H, Wang X, Geng J, et al. Clinical study of styping detection of human papillomavirus (HPV) infection with microarray from paraffinembedded specimens of cervical cancer and precursor lesions[J]. J Nanosci Nanotechnol, 2015, 15(9): 6423-6428.
[6]
Bosch FX, Burchell AN, Schiffman M, et al. Epidemiology and natural history of human papillomavirus infections and type-specific implications in cervical neoplasia[J]. Vaccine, 2008, 26(Suppl 10): K1-K16.
[7]
Benevolo M, Donà MG, Ravenda PS, et al. Anal human papillomavirus infection: prevalence, diagnosis and treatment of related lesions[J]. Expert Rev Anti Infect Ther, 2016, 14(5): 465-477.
[8]
Jiménez-Wences H, Peralta-Zaragoza O, Fernández-Tilapa G. Human papilloma virus, DNA methylation and microRNA expression in cervical cancer (review)[J]. Oncol Rep, 2014, 31(6): 2467.
[9]
Katki HA, Cheung LC, Fetterman B, et al. A joint model of persistent human papillomavirus infection and cervical cancer risk: implications for cervical cancer screening[J]. J R Stat Soc Ser A Stat Soc, 2015, 178(4): 903-923.
[10]
Einstein MH, Burk RD. Persistent human papillomavirus infection: definitions and clinical implications[J]. Papillomavirus Rep, 2001, 12(5): 119-123.
[11]
Gravitt PE, Rositch AF. HPV self-testing and cervical cancer screening coverage[J]. Lancet Oncol, 2014, 15(2): 128-129.
[12]
Castle PE, Schiffman M, Wheeler CM, et al. Human papillomavirus genotypes in cervical intraepithelial neoplasia grade 3[J]. Cancer Epidemiol Biomarkers Prev, 2010, 19(7): 1675-1681.
[13]
Asgary S, Sabbagh S, Eghbal MJ. Published endodontic articles in PubMed-Indexed journals from Iran[J]. Iran Endod J, 2012, 7(1): 1-4.
[14]
Massad LS, Einstein MH, Huh WK, et al. 2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors[J]. Obstet Gynecol, 2013, 121(4): 829-846.
[15]
Ryu A, Nam K, Kwak J, et al. Early human papillomavirus testing predicts residual/recurrent disease after LEEP[J]. J Gynecol Oncol, 2012, 23(4): 217-225.
[16]
缪飞，王秀丽，王宏伟，等. 5-氨基酮戊酸光动力治疗宫颈高危型HPV感染[J]. 中国皮肤性病学杂志，2012, 26(1): 49-50.
[17]
陈晓静，叶菁. 阴道局部干扰素应用对宫颈高危型人乳头瘤病毒感染进程影响的临床研究[J]. 实用妇产科杂志，2016, 32(6): 450-452.
[18]
宣秀芳. 派特灵治疗宫颈HPV高危感染的临床观察[J]. 浙江实用医学，2014, 19(3): 202-203.
[19]
刘小莉. 保妇康栓治疗HPV感染疗效观察[J]. 山西中医，2015, 31(11): 53.
[20]
杨莉. 冷冻联合保妇康栓治疗慢性宫颈炎伴HPV感染的疗效分析[J]. 江苏医药，2016, 42(1): 82-83.
[21]
Schiffman M, Wentzensen N. From human papillomavirus to cervical cancer[J]. Obstet Gynecol, 2010, 116(1): 177-185.
[22]
Schiffman M, Castal PE, Jeronimo J, et al. Human papillomavirus and cervical cancer[J]. Lancet, 2007, 370(9590): 890-907.
[23]
Mayeaux EJ Jr, Cox JT. 现代阴道镜学. 魏丽惠，赵昀，译. 3版[M]. 北京：北京大学医学出版社，2016: 445-455.
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