Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2016, Vol. 12 ›› Issue (03): 344 -348. doi: 10.3877/cma.j.issn.1673-5250.2016.03.017

Special Issue:

Review

Research progress of heat shock protein in ovarian cancer

Jiangnan Qiu1, Yijun Yang1   

  1. 1. Department of Gynecology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
  • Received:2015-12-01 Revised:2016-04-25 Published:2016-06-01
  • About author:
    Corresponding author: Cheng Wenjun, Email:

Heat shock proteins (HSP), which are widely expressed in all kinds of cells, are a set of highly conserved proteins molecules. As their expressions increase under the condition of stress, they are also called stress proteins. Studies have found that HSP play an important role in the genesis and development of various tumors. As one of the three most common malignant tumors in female reproductive system, ovarian cancer has a close relationship with HSP in the tumor genesis, development and resistance to chemotherapy. This article clarifies the biological characteristics of HSP and their relationship with the genesis, development, chemoresistance and therapy of ovarian cancer, so that it can provide reference for the treatment of ovarian cancer.

1
Landriscina M, Amoroso MR, Piscazzi A, et al. Heat shock proteins, cell survival and drug resistance: the mitochondrial chaperone TRAP1, a potential novel target for ovarian cancer therapy[J]. Gynecol Oncol, 2010, 117(2):177-182.
2
Elpek GO, Karaveli S, Simsek T, et al. Expression of heat-shock proteins hsp27, hsp70 and hsp90 in malignant epithelial tumour of the ovaries[J]. APMIS, 2003, 111(4):523-530.
3
Wang Q, An L, Chen Y, et al. Expression of endoplasmic reticulum molecular chaperon GRP94 in human lung cancer tissues and its clinical significance[J]. Chin Med J (Engl), 2002, 115(11):1615-1619.
4
Tanaka K, Kondoh N, Shuda M, et al. Enhanced expression of mRNAs of antisecretory factor-1, gp96, DAD1 and CDC34 in human hepatocellular carcinomas[J]. Biochim Biophys Acta, 2001, 1536(1):1-12.
5
Langmár Z, Vleskó G. The potential role of heat shock proteins in the treatment of ovarian cancer[J]. Orv Hetil, 2011, 152(3):92-95.
6
张敏,刘晓民.热休克蛋白与肿瘤的研究进展[J].中华肺部疾病杂志:电子版,2013,6(6):60-62.
7
Akerfelt M, Trouillet D, Mezger V, et al. Heat shock factors at a crossroad between stress and development[J]. Ann N Y Acad Sci, 2007, 1113:15-27.
8
Samali A, Cotter TG. Heat shock proteins increase resistance to apoptosis[J]. Exp Cell Res, 1996, 223(1):163-170.
9
Tamura Y, Torigoe T, Kukita K, et al. Heat-shock proteins as endogenous ligands building a bridge between innate and adaptive immunity[J]. Immunotherapy, 2012, 4(8):841-852.
10
何杨.HSP27增强卵巢癌细胞对顺铂耐药的研究[D].武汉:华中科技大学,2013.
11
王宏宇.卵巢浆液性囊腺癌与交界性囊腺瘤的差异蛋白质组学分析[D].长春:吉林大学,2010.
12
李雅静,石红.HSP70与突变型P53在卵巢癌中的表达及临床意义[J].山西职工医学院学报,2012,22(5):4-8.
13
Stope MB, Koensgen D, Burchardt M, et al. Jump in the fire-heat shock proteins and their impact on ovarian cancer therapy[J]. Crit Rev Oncol Hemato, 2015, 97:152-156.
14
Bodzek P, Partyka R, Damasiewicz-Bodzek A. Antibodies against Hsp60 and Hsp65 in the sera of women with ovarian cancer[J]. J Ovarian Res, 2014, 7:30.
15
Kang HJ, Moon HS, Chung HW. The expression of FAS-associated factor 1 and heat shock protein 70 in ovarian cancer[J]. Obstet Gynecol Sci, 2014, 57(4):281-290.
16
Hoffman-Goetz L, Spagnuolo PA. Effect of repeated exercise stress on caspase 3, Bcl-2, HSP 70 and CuZn-SOD protein expression in mouse intestinal lymphocytes[J]. J Neuroimmunol, 2007, 187(1-2):94-101.
17
Vidyasagar A, Wilson NA, Djamali A. Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target[J]. Fibrogenesis Tissue Repair, 2012, 5(1):7.
18
Takeuchi K, Nakajima M, Miyazaki T, et al. Is p53 and heat shock protein 70 expression a useful parameter for preoperative hyperthermoradiation therapy in advanced rectal carcinoma[J]. Hepatogastroenterology, 2007, 54(74):367-372.
19
Akyol S, Gercel-Taylor C, Reynolds LC, et al. HSP-10 in ovarian cancer: expression and suppression of T-cell signaling[J]. Gynecol Oncol, 2006, 101(3):481-486.
20
Suzuki M, Matsushima-Nishiwaki R, Kuroyanagi G, et al. Regulation by heat shock protein 22 (HSPB8) of transforming growth factor-alpha-induced ovary cancer cell migration[J]. Arch Biochem Biophys, 2015, 571:40-49.
21
Pavan S, Musiani D, Torchiaro E, et al. HSP27 is required for invasion and metastasis triggered by hepatocyte growth factor[J]. Int J Cancer, 2014, 134(6):1289-1299.
22
宋晓敏.分泌型热休克蛋白90α在肿瘤发生和转移中的作用机理[D].北京:清华大学,2010.
23
Elstrand MB, Stavnes HT, Trope CG, et al. Heat shock protein 90 is a putative therapeutic target in patients with recurrent advanced-stage ovarian carcinoma with serous effusions[J]. Hum Pathol, 2012, 43(4):529-535.
24
Song TF, Zhang ZF, Liu L, et al. Small interfering RNA-mediated silencing of heat shock protein 27 (HSP27) increases chemosensitivity to paclitaxel by increasing production of reactive oxygen species in human ovarian cancer cells (HO8910)[J]. J Int Med Res, 2009, 37(5):1375-1388.
25
Yang X, Wang J, Zhou Y, et al. Hsp70 promotes chemoresistance by blocking Bax mitochondrial translocation in ovarian cancer cells[J]. Cancer Lett, 2012, 321(2):137-143.
26
Milicevic ZT, Petkovic MZ, Drndarevic NC, et al. Expression of heat shock protein 70 (HSP70) in patients with colorectal adenocarcinoma-immunohistochemistry and Western blot analysis[J]. Neoplasma, 2007, 54(1):37-45.
27
Sugimura M, Sagae S, Ishioka S, et al. Mechanisms of paclitaxel-induced apoptosis in an ovarian cancer cell line and its paclitaxel-resistant clone[J]. Oncology, 2004, 66(1):53-61.
28
Afanasyeva EA, Komarova EY, Larsson LG, et al. Drug-induced Myc-mediated apoptosis of cancer cells is inhibited by stress protein Hsp70[J]. Int J Cancer, 2007, 121(12):2615-2621.
29
Yang L, Li H, Jiang Y, et al. Inhibition of mortalin expression reverses cisplatin resistance and attenuates growth of ovarian cancer cells[J]. Cancer Lett, 2013, 336(1):213-221.
30
Zhao M, Ding JX, Zeng K, et al. Heat shock protein 27: a potential biomarker of peritoneal metastasis in epithelial ovarian cancer?[J]. Tumour Biol, 2014, 35(2):1051-1056.
31
Calderwood SK, Murshid A, Gong J. Heat shock proteins: conditional mediators of inflammation in tumor immunity[J]. Front Immunol, 2012, 3:75.
32
Li D, Li H, Zhang P, et al. Heat shock fusion protein induces both specific and nonspecific anti-tumor immunity[J]. Eur J Immunol, 2006, 36(5):1324-1336.
33
Gong J, Zhang Y, Durfee J, et al. A heat shock protein 70-based vaccine with enhanced immunogenicity for clinical use[J]. J Immunol, 2010, 184(1):488-496.
34
Yuan J, Kashiwagi S, Reeves P, et al. A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma[J]. J Hematol Oncol, 2014, 7:15.
35
杨淑莉,金月梅,付莉,等.负载gp96多肽复合物的树突状细胞抗耐药卵巢癌细胞株作用的实验研究[J].中国妇幼保健,2008,23(33):4759-4762.
36
Olejek A, Damasiewicz-Bodzek A, Bodzek P, et al. Concentrations of antibodies against heat shock protein 27 in the sera of women with ovarian carcinoma[J]. Int J Gynecol Cancer, 2009, 19(9):1516-1520.
37
Zhang Z, Xie Z, Sun G, et al. Reversing drug resistance of cisplatin by hsp90 inhibitors in human ovarian cancer cells[J]. Int J Clin Exp Med, 2015, 8(5):6687-6701.
38
Han FF, Li L, Shang BY, et al. Hsp90 inhibitor geldanamycin enhances the antitumor efficacy of enediyne lidamycin in association with reduced DNA damage repair[J]. Asian Pac J Cancer Prev, 2014, 15(17):7043-7048.
39
孙广宇.格尔德霉素及其顺铂联合应用对人卵巢癌细胞SKOV3及SKOV3/DDP耐药性影响的研究[D].石家庄:河北医科大学,2012.
40
Oude Munnink TH, Korte MA, Nagengast WB, et al. 89Zr-trastuzumab PET visualises HER2 downregulation by the HSP90 inhibitor NVP-AUY922 in a human tumour xenograft[J]. Eur J Cancer, 2010, 46(3):678-684.
41
Vesci L, Milazzo FM, Carollo V, et al. Preclinical antitumor activity of SST0116CL1: a novel heat shock protein 90 inhibitor[J]. Int J Oncol, 2014, 45(4):1421-1429.
42
Li W, Wang W, Dong H, et al. Cisplatin-induced senescence in ovarian cancer cells is mediated by GRP78[J]. Oncol Rep, 2014, 31(6):2525-2534.
43
Elstrand MB, Kleinberg L, Kohn EC, et al. Expression and clinical role of antiapoptotic proteins of the bag, heat shock, and Bcl-2 families in effusions, primary tumors, and solid metastases in ovarian carcinoma[J]. Int J Gynecol Pathol, 2009, 28(3):211-221.
44
Lv Q, Sun H, Cao C, et al. Overexpression of tumor necrosis factor receptor-associated protein 1 (TRAP1) are associated with poor prognosis of epithelial ovarian cancer[J]. Tumour Biol, 2016, 37(2):2721-2727.
[1] Jingyu Qian, Mingming Zheng. Interpretation of the Italian guidelines on non-invasive and invasive prenatal diagnosis:executive summary of recommendations for practice the Italian Society for Obstetrics and Gynecology(SIGO)[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 486-492.
[2] Xialin Li, Fang He. Risk assessment and early warning system for postpartum hemorrhage[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 498-503.
[3] Ziyang Liu, Jianjian Cui, Yin Zhao. Current research status on obstetric disseminated intravascular coagulation and its scoring system[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 511-518.
[4] Fanying Zeng, Jie Ruan, Xinghui Liu, Guolin He. Current status of perinatal medicine advances under the new reproductive situation and coping strategies in prenatal care[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 519-524.
[5] Xiaofei Li, Hongli Liu, Qiuling Shi, Jing Tian, Li Li, Hongbo Qi, Xin Luo. A prospective randomized controlled study of low intensity focused ultrasound uterine involution treatment for prevention and treatment of postpartum hemorrhage in natural childbirth women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 534-539.
[6] Rong Huang, Ziyu Liang, Wenjin Qi. Expression and significance of NLRP3 inflammasome in serum of pregnant women with premature rupture of membranes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 540-548.
[7] Xia He, Rong Huang, Wenjin Qi. High-throughput sequencing study on the abundance of placenta and fetal membrane flora in pregnant women with premature rupture of membranes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 549-555.
[8] Jiangyan Xie, Yafei Wang, Fang He. Pregnancy complicated with thrombotic thrombocytopenic purpura:two cases report and literature review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 556-563.
[9] Jinhan Yao, Weina Wang, Yuquan Zhang. Current research status on prognosis of patients with pregnancy-related deep vein thrombosis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 367-373.
[10] Tingting Xu, Yongchi Zhan, Xiaodong Wang, Xiaodong Wang. Perinatal outcomes of fetomaternal hemorrhage syndrome pregnant women with sinusoidal fetal heart tracing[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 382-389.
[11] Xiaoyan Han, Hua Yang. Relationship between low level of serum placental growth factor in the second trimester pregnancy women and adverse fetal prognosis[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 398-402.
[12] Chenglin Piao, Xin Lan, Zhenduo Si, Qiang Li, Jian Feng, Fengduo An, Jianjun Leng. Analysis of the therapeutic effect of pancreaticoduodenectomy combined with liver resection: A report of 5 cases (video attached)[J]. Chinese Archives of General Surgery(Electronic Edition), 2024, 18(05): 363-367.
[13] Huazhi Li, Guang Cao, Diangang Liu, Yajing Zhang. Clinical comparison of descending hepatectomy with different approaches for primary hepatocellular carcinoma[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2025, 19(01): 52-55.
[14] Yuefang Xu, Wang Liu, Miaotian Zeng, Yushu Guo. Clinical efficacy of polymyxin B and polymyxin E in the treatment of surgical multi-drug resistant infections Security analysis[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(06): 700-703.
[15] Yifan Li, Diwen Zhu, Weixin Ren, Yingjun Bao, Junpeng Gu, Haixiao Zhang, Gengfei Cao, Weizheng Ji. Role of serum GP73 level in the evaluation of TACE efficacy for primary liver cancer[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(06): 825-830.
Viewed
Full text


Abstract