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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2015, Vol. 11 ›› Issue (05): 613 -616. doi: 10.3877/cma.j.issn.1673-5250.2015.05.013

Special Issue: ；

Original Article

Analysis of Mycoplasma pneumoniae and Legionella pneumophila IgM antibody testing results in children with acute respiratory tract infection

Yulu Wu1, Chengbin Xie1(), Zhe Su1, Juan Yi1, Yuan Yan1, Shuying Zhu1, Xuemei Ni1   

  1. 1. Department of Clinical Laboratory, Sichuan Provincial Hospital of Women and Children, Chengdu 610045, Sichuan Province, China
  • Received:2015-05-03 Revised:2015-08-27 Published:2015-10-01
  • Corresponding author: Chengbin Xie
  • About author:
    Corresponding author: Xie Chengbin, Email:
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Objective

To investigate Mycoplasma pneumoniae(MP) and Legionella pneumophila serogroup 1(LP1) infection and epidemiologic characteristics in children with acute respiratory tract infection(ARI).

Methods

A total of 1 167 children who were diagnosed as ARI in Sichuan Provincial Hospital of Women and Children from January to December in 2013 were chosen as study subjects.Indirect immunofluorescence assay was used to detect serum IgM antibody of MP and LP1.The positive detection rates were compared statistically amomg different quarters of 2013, age and gender.

Results

①The positive detection rates of MP, LP1 and MP+ LP1 were 25.0%, 7.4% and 4.3% respectively in 1 167 ARI patients.②The positive detection rate of MP in the second quarter of 2013(36.5%) was higher than that in the first, the third and the fourth quarter of 2013(21.2%, 23.1%, 22.6%), and the differences were statistically significant(χ2=7.57, 12.07, 13.55; P<0.01). There were no significant differences among LP1 and MP+ LP1 positive detection rates in different quarters of 2013(χ2=6.57, 5.88; P>0.05). ③There were no significant differences among the positive detection rates of MP, LP1 and MP+ LP1 in different age of children with ARI (χ2=199.01, 35.18, 19.89; P<0.01), and the positive detection rates of MP, LP1 and MP+ LP1 increased with increasing age of children with ARI.④The positive detection rate of MP in female children with ARI was higher than that in male, and the difference was statistically significant(29.0% vs 22.6%, χ2=5.88, P<0.05); but there were no significant differences of LP1 and MP+ LP1 positive detection rates in different gender(P>0.05).

Conclusion

The children with ARI had high positive detection rates of MP and LP1, and should be paid enough attention by paediatricians.

Key words: Mycoplasma pneumoniae, Legionella pneumophila, Immunoglobulin M, Child
表1 2013年不同季度本组ARI患儿MP、LP1和MP＋LP1阳性检出率比较[例数(%)]
季度 例数 MP LP1 MP＋LP1
一季度 108 23(21.2) 12(11.1) 9(8.3)
二季度 197 72(36.5) 11 (5.6) 8(4.1)
三季度 415 96(23.1) 38 (9.1) 19(4.6)
四季度 447 101(22.6) 26 (5.8) 14(3.1)
χ2值   16.94 6.57 5.88
P值   <0.01 >0.05 >0.05
表2 不同年龄ARI患儿的MP、LP1及MP＋LP1阳性检出率比较[例数(%)]
年龄(岁) 例数 MP LP1 MP＋LP1
<1 622 53 (8.5) 25 (4.0) 15 (2.4)
≥1～3 312 125(40.1) 32(10.3) 25 (8.0)
≥3～6 194 94(48.5) 20(10.3) 16 (8.2)
≥6～14 39 20(51.3) 10(25.6) 4(10.2)
χ2值   199.01 35.18 19.89
P值   <0.01 <0.01 <0.01
表3 不同性别ARI患儿MP、LP1和MP＋LP1阳性检出率比较[例数(%)]
性别 例数 MP LP1 MP＋LP1
男性 725 164(22.6) 54(7.4) 30(4.1)
女性 442 128(29.0) 33(7.5) 20(4.5)
χ2值   5.88 0.00 0.10
P值   <0.05 >0.05 >0.05
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