[1] |
中华医学会儿科学分会呼吸学组,《中华儿科杂志》编辑委员会.儿童支气管哮喘诊断与防治指南[J].中华儿科杂志,2008,46(10):745–753.
|
[2] |
Hill VL,Wood PR.Asthma epidemiology,pathophysiology,and initial evaluation[J].Pediatr Rev,2009,30(9):331–335.
|
[3] |
Burke W, Fesinmeyer M, Reed K,et al.Family history as a predictor of asthma risk[J].Am J Prev Med,2003,24(2):160–169.
|
[4] |
Masoli M,Fabian D,Holt S,et al.The global burden of asthma:executive summary of the GINA Dissemination Committee report[J].Allergy,2004,59(5):469–478.
|
[5] |
全国儿科哮喘协作组,中国疾病预防控制中心环境与健康相关产品安全所.第三次中国城市儿童哮喘流行病学调查[J].中华儿科杂志,2013,51(10):729–735.
|
[6] |
Bønnelykke K, Sleiman P, Nielsen K,et al.A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations[J].Nat Genet,2014,46(1):51–55.
|
[7] |
Hulpiau P, van Roy F. Molecular evolution of the cadherin superfamily[J]. Int J Biochem Cell Biol,2009,41(2):349–369.
|
[8] |
Nawijn MC, Hackett TL, Postma DS,et al. E-cadherin:gatekeeper of airway mucosa and allergic sensitization[J]. Trends Immunol,2011,32(6):248–255.
|
[9] |
Koppelman GH, Meyers DA, Howard TD, et al. Identification of PCDH1 as a novel susceptibility gene for bronchial hyperresponsiveness[J]. Am J Respir Crit Care Med,2009,180(10):929–935.
|
[10] |
Schmitz J, Owyang A, Oldham E,et al.IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].Immunity,2005,23(5):479–490.
|
[11] |
Netea MG, Van Der Graaf CA, Vonk AG,et al.The role of toll-like receptor (TLR) 2 and TLR4 in the host defense against disseminated candidiasis[J].J Infect Dis,2002,185(10):1483–1489.
|
[12] |
Villamón E, Gozalbo D, Roig P,et al.Toll-like receptor-2 is essential in murine defenses against Candida albicans infections[J].Microbes Infect,2004,6(1):1–7.
|
[13] |
Gantner BN, Simmons RM, Canavera SJ,et al.Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2[J].J Exp Med,2003,197(9):1107–1117.
|
[14] |
Borish L,Steinke JW.Interleukin-33 in asthma:how big of a role does it play?[J].Curr Allergy Asthma Rep,2011,11(1):7–11.
|
[15] |
Kamekura R,Kojima T,Takano K,et al. The role of IL-33 and its receptor ST2 in human nasal epithelium with allergic rhinitis[J].Clin Exp Allergy,2012,42(2):218–228.
|
[16] |
Roussel L, Erard M, Cayrol C, et al.Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket[J].EMBO Rep,2008,9(10):1006–1012.
|
[17] |
Carriere V, Roussel L, Ortega N,et al.IL-33,the IL-1-like cytokine ligand for ST2 receptor, is a chromatin-associated nuclear factor in vivo[J].Proc Natl Acad Sci U S A,2007,104(1):282–287.
|
[18] |
Préfontaine D, Lajoie-Kadoch S, Foley S,et al.Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells[J].J Immunol. 2009,183(8):5094–5103.
|
[19] |
Savenije OE,Mahachie John JM,Granell R,et al.Association of IL-33-IL-1 receptor-like 1 (IL1RL1) pathway polymorphisms with wheezing phenotypes and asthma in childhood[J].J Allergy Clin Immunol,2014,134(1):170–177.
|
[20] |
Gudbjartsson DF, Bjornsdottir US, Halapi E,et al.Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction[J].Nat Genet,2009,41(3):342–347.
|
[21] |
Weidinger S, Gieger C, Rodriguez E, et al.Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus[J]. PLoS Genet,2008,4(8):e1000166.
|
[22] |
Rosenberg HF, Phipps S, Foster PS. Eosinophil trafficking in allergy and asthma[J]. J Allergy Clin Immunol,2007,119(6):1303–1310.
|
[23] |
Akhabir L, Sandford AJ.Genome-wide association studies for discovery of genes involved in asthma[J].Respirology,2011,16(3):396–406.
|
|
Lee GR, Fields PE, Griffin TJ,et al. Regulation of the Th2 cytokine locus by a locus control region[J]. Immunity,2003,19(1):145–153.
|
[24] |
Li X, Howard TD, Zheng SL.Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions[J].J Allergy Clin Immunol,2010,125(2):328–335.
|
[25] |
Tulah AS,Holloway JW,Sayers I,et al.Defining the contribution of SNPs identified in asthma GWAS to clinical variables in asthmatic children[J].BMC Med Genet,2013,14:100.
|