Newborn infants are special groups of children. Their pharmacokinetics and pharmacodynamics are significantly different from those of children and adults. In the past, children and adults medication experiences were used on newborn infants and then caused severe consequence. Due to the high cost, high risk, ethical issues, difficulty of participant recruitment and other issues of neonatal clinical medication, neonatal clinical medication still needs to be strengthened and highlighted up to now. At present, as many countries have made laws and regulations to promote and regulate the children clinical medication, and new research techniques and methods have been applied to neonatal clinical medication, neonatal clinicians, clinical pharmacists and other researchers should work together to improve the progress of neonatal clinical medication and ensure the safety and effectiveness of neonatal clinical medication.