Impact on Fetal Growth in Fetal With an Isolated Single Umbilical Artery

doi:10.3877/cma.j.issn.1673-5250.2013.05.009

Objective

To determine whether fetuses with an isolated single umbilical artery (SUA) were associated with fetal growth.

Methods

Eighty singleton pregnancies with isolated SUAs diagnosed and delivered from January 2009 to December in our hospital were selected as experimental group. Multiple pregnancies, fetuses with other system malformation and abnormal placenta or amniotic fluid were excluded. For control group, 80 normal singleton pregnancies were searched and paired at a ratio of 1∶1 during the same period in the same hospital The study protocol was approved by the Ethical Review Board of Investigation in Human Being of West China Second University Hospital, Sichuan University. Informed consent was obtained from the parents of each participating neonate.. The statistical analysis was used in two groups collected by retrospective analysis.

Results

①The accuracy of diagnose was 95.2% (80/84) in this study. ②There were no significant differences in age, pregnant, pregnancy, gestational diabetes mellitus(GDM) and gestational hypertension(GH) between two groups (P>0.05). ③No significant difference was observed in neonatal sex between the two groups(P>0.05). ④There were significant differences in birth weight and height between SUA group and control group(P<0.05).

Conclusions

Compared with the normal fetuses, the birth weight is lighter and the birth height is shorter in fetuses with an isolated SUA.

Key words: single umbilical artery, birth weight, birth height, ultrasonography, prenatal

表1 SUA组与对照组胎儿的一般临床资料比较(±s)

Table 1 Comparison of related clinical data between SUA group and control group(±s)

组别	n	孕妇年龄(岁)	孕次	产次	GDM发生率[n(%)]	GH发生率[n(%)]
SUA组	80	29.0±3.5	2.1±0.6	1.1±0.4	7(8.8)	2(2.5)
对照组	80	28.1±5.2	1.8±0.5	1.1±0.2	6(7.5)	1(1.3)
t/χ²	?	3.08	10.78	8.54	3.08	2.99
P	?	0.20	0.07	0.08	0.07	0.07

表1 SUA组与对照组胎儿的一般临床资料比较(±s)

Table 1 Comparison of related clinical data between SUA group and control group(±s)

组别	n	孕妇年龄(岁)	孕次	产次	GDM发生率[n(%)]	GH发生率[n(%)]
SUA组	80	29.0±3.5	2.1±0.6	1.1±0.4	7(8.8)	2(2.5)
对照组	80	28.1±5.2	1.8±0.5	1.1±0.2	6(7.5)	1(1.3)
t/χ²	?	3.08	10.78	8.54	3.08	2.99
P	?	0.20	0.07	0.08	0.07	0.07

表2 SUA组与对照组胎儿的围生期结局比较(±s)

Table 2 Comparison of pregnancy outcomes between SUA group and control group(±s)

组别	n	出生体重(kg)	出生身高(cm)	性别[n(%)]
组别	n	出生体重(kg)	出生身高(cm)	男性	女性
SUA组^a	80	2.96±0.06	45.21±0.91	40(50.0)	40(50.0)
对照组^b	80	3.21±0.04	47.99±0.32	42(52.5)	38(47.5)
组间差值^b-a	80	0.25±0.03	2.78±0.55	?	?
t/χ²	?	58.21	43.54	2.23	2.70
P	?	0.012	0.016	0.18	0.10

表2 SUA组与对照组胎儿的围生期结局比较(±s)

Table 2 Comparison of pregnancy outcomes between SUA group and control group(±s)

组别	n	出生体重(kg)	出生身高(cm)	性别[n(%)]
组别	n	出生体重(kg)	出生身高(cm)	男性	女性
SUA组^a	80	2.96±0.06	45.21±0.91	40(50.0)	40(50.0)
对照组^b	80	3.21±0.04	47.99±0.32	42(52.5)	38(47.5)
组间差值^b-a	80	0.25±0.03	2.78±0.55	?	?
t/χ²	?	58.21	43.54	2.23	2.70
P	?	0.012	0.016	0.18	0.10

1	Gornall AS, Kurinczuk JJ, Konje JC. Antenatal detection of a single umbilical artery: Does it matter[J]? Prenat Diagn, 2003, 23(2)：117-123.
2	Granese R, Coco C, Jeanty P. The value of single umbilical artery in the prediction of fetal aneuploidy: Findings in 12，672 pregnant women[J]. Ultrasound Q, 2007, 23(2)：117-121.
3	Burshtein S, Levy A, Holcberg G, et al. Is single umbilical artery an independent risk fact for perinatal mortality[J]? Arch Gynecol Obstet, 2011, 283(2)：191-194.
4	Persntte WH, Hobbins J．Single umbilical artery：A clinical enigmain modern prenatal diagnosis[J]．Ultrasound Obstet Gynecol，1995，8(2)：216-229.
5	Mu SC, Lin CH, Chen YL，et al.The perinatal outcomes of asymptomatic isolated single umbilical artery in full-term neonates[J]. Pediatr Neonatol，2008, 49(6)：230-233.
6	Hu RX, Peng QH, Tian LQ, et al. Clinical study of single umbilical artery by antenatal sonographic diagnosis[J]. J Clin Res，2007, 24(6)：971-973.
7	Suess G, Raio L, Kuhn A, et al. Arterial-adaptive dilatation and Doppler velocimetry in normal fetuses with a single umbilical artery[J]. Ultraschall Med，2009, 30(5)：485-489.
8	Cristina MP, Ana G, Inés T，et al. Perinatal results following the prenatal ultrasound diagnosis of single umbilical artery[J]. Acta Obstet Gynecol Scand，2005, 84(11)：1068-1074.
9	Dagklis T, Defigueiredo D, Staboulidou I, et al. Isolated single umbilical artery and fetal karyotype[J]. Ultrasound Obstet Gynecol，2010, 36(3)：291-295.
10	Chetty-John S, Zhang J, Chen Z, et al. Long-term physical and neurologic development in newborn infants with isolated single umbilical artery[J]. Am J Obstet Gynecol，2010, 203(4)：368.e1-e7.
11	Deshpande SA, Jog S, Watson H, et al. Do babies with isolated single umbilical artery need routine postnatal renal ultrasonography[J]? Arch Dis Child Fetal Neonatal Ed，2009, 94(4)：F265-267.

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