Clinical Analysis of 75 Children With Congenital Syphilis

doi:10.3877/cma.j.issn.1673-5250.2013.04.017

Objective

To investigate clinical feature of the congenital syphilis (CS) and whether combined with other infections such as TORCH infection and organ damage.

Methods

From February 2006 to October 2010, 75 cases diagnosed as CS were included into this study. According to whether with or without TORCH infection, which were divided into pure CS group (n=39) and CS combined with TORCH group (n=36). General data of two groups had no significant difference (P>0.05). This study protocol was approred by the Ethical Review Board of Investigation in Human being of this hospital. Informal consent was obtained from guardians of children. The children in the two groups were compared and analyzed in multiple system lesions and laboratory test results, etc..

Results

In liver hepato splenomegaly, anemia, thrombocytopenia, elevated transaminases, hypoproteinemia and chest X ray, the difference of the children in group CS and group CS with TORCH infection were statistically significant (P<0.05).

Conclusions

The incidence of other organ damage in the respiratory system, digestive system, blood system increased significantly, aminotransferase levels increased obviously, the degree of liver damage was more serious in CS children combined with TORCH infection.

Key words: newborn, congenital syphilis, TORCH infection, multi-system damage

表1 合并TORCH感染的构成比[n(%)]

Table 1 The constituent ratio of children with CS combined with TORCH [n(%)]

合并其他TORCH感染	n(%)
TP＋HSV	3 (8.3)
TP＋RV	11(30.6)
TP＋CMV	8(22.2)
TP＋HSV＋RV	10(27.8)
TP＋CMV＋RV	0 (0.0)
TP＋CMV＋HSV	1 (2.8)
TP＋CMV＋RV＋HSV	3 (8.3)

表1 合并TORCH感染的构成比[n(%)]

Table 1 The constituent ratio of children with CS combined with TORCH [n(%)]

合并其他TORCH感染	n(%)
TP＋HSV	3 (8.3)
TP＋RV	11(30.6)
TP＋CMV	8(22.2)
TP＋HSV＋RV	10(27.8)
TP＋CMV＋RV	0 (0.0)
TP＋CMV＋HSV	1 (2.8)
TP＋CMV＋RV＋HSV	3 (8.3)

表2 2组患儿临床表现[n(%)]

Table 2 The clinical manifestation of two groups [n(%)]

组别	n	肝、脾大	贫血	血小板计数减少	转氨酶水平升高	低蛋白血症	胸部X射线摄片结果异常	白细胞计数升高
单纯CS组	39	13(33.3)	15(38.4)	4(10.3)	17(43.6)	8(20.5)	21(53.8)	29(74.4)
合并TORCH组	36	24(66.7)	23(63.9)	13(36.1)	34(94.4)	19(52.8)	32(88.9)	27(75.0)
校正χ²	?	8.321	4.842	7.139	22.249	8.458	11.090	0.004
P	?	0.004	0.028	0.008	0.000	0.004	0.001	0.949
组别	n	胆红素升高	低出生体重儿	产时窒息	皮疹	颅内出血	尿常规异常
单纯CS组	39	13(33.3)	9(23.1)	6(15.4)	19(48.7)	4(10.3)	7(17.9)
合并TORCH组	36	13(36.1)	14(38.9)	11(30.6)	19(52.8)	8(22.2)	12(33.3)
校正χ²	?	0.064	2.201	2.458	0.123	1.994	2.342
P	?	0.801	0.138	0.117	0.725	0.158	0.126

表2 2组患儿临床表现[n(%)]

Table 2 The clinical manifestation of two groups [n(%)]

组别	n	肝、脾大	贫血	血小板计数减少	转氨酶水平升高	低蛋白血症	胸部X射线摄片结果异常	白细胞计数升高
单纯CS组	39	13(33.3)	15(38.4)	4(10.3)	17(43.6)	8(20.5)	21(53.8)	29(74.4)
合并TORCH组	36	24(66.7)	23(63.9)	13(36.1)	34(94.4)	19(52.8)	32(88.9)	27(75.0)
校正χ²	?	8.321	4.842	7.139	22.249	8.458	11.090	0.004
P	?	0.004	0.028	0.008	0.000	0.004	0.001	0.949
组别	n	胆红素升高	低出生体重儿	产时窒息	皮疹	颅内出血	尿常规异常
单纯CS组	39	13(33.3)	9(23.1)	6(15.4)	19(48.7)	4(10.3)	7(17.9)
合并TORCH组	36	13(36.1)	14(38.9)	11(30.6)	19(52.8)	8(22.2)	12(33.3)
校正χ²	?	0.064	2.201	2.458	0.123	1.994	2.342
P	?	0.801	0.138	0.117	0.725	0.158	0.126

表3 2组转氨酶升高水平比较(U)

Table 3 Comparison of transaminase levels of two groups(U)

组别	ALT			AST
组别	P₂₅	P₅₀	P₇₅	P₂₅	P₅₀	P₇₅
单纯CS组	95.3000	105.0000	156.6000	99.0000	113.2000	154.9000
合并TORCH组	95.0000	166.0000	300.0000	135.9000	316.0000	443.0000
Z	－14.948			－40.079
P	0.000			0.000

表3 2组转氨酶升高水平比较(U)

Table 3 Comparison of transaminase levels of two groups(U)

组别	ALT			AST
组别	P₂₅	P₅₀	P₇₅	P₂₅	P₅₀	P₇₅
单纯CS组	95.3000	105.0000	156.6000	99.0000	113.2000	154.9000
合并TORCH组	95.0000	166.0000	300.0000	135.9000	316.0000	443.0000
Z	－14.948			－40.079
P	0.000			0.000

1	Wang GC, ed. Dermatovenereology[M]. Beijing: People's Medical Publishing House, 1994, 120.
2	Chen ZQ, Zhang GC, Gong XD, et al. Syphilis in china: Results of a national surveillance programme[J]. Lancet, 2007, 369(9556): 132-138.
3	Jing HZ, Huang DM, Guan XJ. Practical of neonatology. 3rd ed[M]. Beijing: People's Medical Publishing House, 2008, 359-362.
4	Hu YM, Jiang ZF, Zhu FT. Practical pediatrics. 7th ed[M]. Beijing: People's Medical Publishing House, 2002, 1022-1026.
5	Cao YX, Qiu LX, Zhang PL, et al. Study on the relationship between the history of abnormal pregnancy and TORCH infection in pregnant woman[J]. Chin J Obstet Gynecol, 1999, 34(9): 517.
6	Shen CY, Chang SF, Chao MF, et al. Cytomegalovirus recurrence in seropositive pregnant women attending obstetric clinics[J]. J Med Virol, 1993, 41(1): 24-29.

[1]	Bo Li, Dexuan Kong, Fanghua Peng, Wenying Wu. Value of ultrasound in diagnosis of fetal anomalous pulmonary venous connection[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(04): 437-441.
[2]	Yanjuan Bao, Xiaohong Yang, Xinghai Yang, Shengbao Pan, Fan Yang, Sheng Zhao. Clinical and ultrasonographic features of retroperitoneal fetus in fetu in prenatal and neonatal period[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(12): 1349-1354.
[3]	Yanhua Xie, Weiling Chen, Zijian Tang, Hongwei Tao, Xuezhi He, Bingxuan Huang, Na Xu, Bei Xia. Ultrasound diagnosis of septic hip arthritis in neonates and small infants: a case series[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2022, 19(12): 1377-1382.
[4]	Ruizhi Dai, Meichi Huo, Zheng Li. Clinical efficacy of noninvasive high-frequency oscillation ventilation in premature infants with respiratory distress syndrome[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2022, 15(05): 372-378.
[5]	Xiaoyan Dong, Qi Zhao, Jun Tang, Li Zhang, Xiaoyan Yang, Jiao Li. Clinical characteristics of neonates infected with the Omicron variant of severe acute respiratory syndrome coronavirus 2[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 595-603.
[6]	Xu Wei, Ge Zhang, Jinlin Wu. Monitoring and treatment of neonatal sepsis-induced coagulopathy[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 379-386.
[7]	Ying Yang, Yan Liu, Yangdan Wang. Neonatal tuberous sclerosis complex related epilepsy: a case report and literature review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 464-472.
[8]	Jinqi Zhao, Nan Yang, Lifei Gong, Yue Tang, Lulu Li, Haihe Yang, Yuanyuan Kong. Analysis on birth status of small for gestational age infants in Beijing, 2011-2020[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(03): 278-286.
[9]	Yulian Chen, Hanmin Liu. Research progress on respiratory system microflora and development characteristics of lung microbiome and homeostasis of lung microflora in early life[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(01): 31-37.
[10]	Wen Zhang, Hongyan Xu, Yanchun Zhang, Kaibo Liu. Epidemiological analysis of congenital heart disease in Beijing from 2017 to 2021[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(01): 61-68.
[11]	Dongming Li, Sheng He. Research progress on early screening for congenital cytomegalovirus infection[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(06): 627-633.
[12]	Xiao Hao, Xingli Liu, Xiaoye Xia, Xueqin Diao, Meixue Yao. Predictive analysis of maternal immunoglobulin G irregular antibody titer and titer score on blood exchange transfusion in rhesus maternal-fetal blood group incompatibility hemolytic disease of newborn[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(06): 677-684.
[13]	Jiali Li, Yang Wu, Li Zhang, Bin Xia, Yang He, Zhong Chen, Jun Tang, Dezhi Mu. Clinical characteristics and outcomes of neonatal gastrointestinal perforation[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2022, 18(06): 703-711.
[14]	Jinglei Ji, Xiuli Li, Yanan Jia, Huimin Feng, Liyan Liu. Evaluation of brain injury in high-risk full-term low body weight newborns by modified aEEG scores[J]. Chinese Journal of Neurotraumatic Surgery(Electronic Edition), 2023, 09(03): 165-169.
[15]	Guangfeng Qiang, Lanlan Meng, Jing Zhao, Fenghai Niu, Xueyun Ren. Predictive value of lung ultrasound scores for the use of invasive mechanical ventilation in neonates with respiratory distress[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(02): 104-108.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export