Clinical Analysis of 75 Children With Congenital Syphilis

doi:10.3877/cma.j.issn.1673-5250.2013.04.017

Objective

To investigate clinical feature of the congenital syphilis (CS) and whether combined with other infections such as TORCH infection and organ damage.

Methods

From February 2006 to October 2010, 75 cases diagnosed as CS were included into this study. According to whether with or without TORCH infection, which were divided into pure CS group (n=39) and CS combined with TORCH group (n=36). General data of two groups had no significant difference (P>0.05). This study protocol was approred by the Ethical Review Board of Investigation in Human being of this hospital. Informal consent was obtained from guardians of children. The children in the two groups were compared and analyzed in multiple system lesions and laboratory test results, etc..

Results

In liver hepato splenomegaly, anemia, thrombocytopenia, elevated transaminases, hypoproteinemia and chest X ray, the difference of the children in group CS and group CS with TORCH infection were statistically significant (P<0.05).

Conclusions

The incidence of other organ damage in the respiratory system, digestive system, blood system increased significantly, aminotransferase levels increased obviously, the degree of liver damage was more serious in CS children combined with TORCH infection.

Key words: newborn, congenital syphilis, TORCH infection, multi-system damage

表1 合并TORCH感染的构成比[n(%)]

Table 1 The constituent ratio of children with CS combined with TORCH [n(%)]

合并其他TORCH感染	n(%)
TP＋HSV	3 (8.3)
TP＋RV	11(30.6)
TP＋CMV	8(22.2)
TP＋HSV＋RV	10(27.8)
TP＋CMV＋RV	0 (0.0)
TP＋CMV＋HSV	1 (2.8)
TP＋CMV＋RV＋HSV	3 (8.3)

表1 合并TORCH感染的构成比[n(%)]

Table 1 The constituent ratio of children with CS combined with TORCH [n(%)]

合并其他TORCH感染	n(%)
TP＋HSV	3 (8.3)
TP＋RV	11(30.6)
TP＋CMV	8(22.2)
TP＋HSV＋RV	10(27.8)
TP＋CMV＋RV	0 (0.0)
TP＋CMV＋HSV	1 (2.8)
TP＋CMV＋RV＋HSV	3 (8.3)

表2 2组患儿临床表现[n(%)]

Table 2 The clinical manifestation of two groups [n(%)]

组别	n	肝、脾大	贫血	血小板计数减少	转氨酶水平升高	低蛋白血症	胸部X射线摄片结果异常	白细胞计数升高
单纯CS组	39	13(33.3)	15(38.4)	4(10.3)	17(43.6)	8(20.5)	21(53.8)	29(74.4)
合并TORCH组	36	24(66.7)	23(63.9)	13(36.1)	34(94.4)	19(52.8)	32(88.9)	27(75.0)
校正χ²	?	8.321	4.842	7.139	22.249	8.458	11.090	0.004
P	?	0.004	0.028	0.008	0.000	0.004	0.001	0.949
组别	n	胆红素升高	低出生体重儿	产时窒息	皮疹	颅内出血	尿常规异常
单纯CS组	39	13(33.3)	9(23.1)	6(15.4)	19(48.7)	4(10.3)	7(17.9)
合并TORCH组	36	13(36.1)	14(38.9)	11(30.6)	19(52.8)	8(22.2)	12(33.3)
校正χ²	?	0.064	2.201	2.458	0.123	1.994	2.342
P	?	0.801	0.138	0.117	0.725	0.158	0.126

表2 2组患儿临床表现[n(%)]

Table 2 The clinical manifestation of two groups [n(%)]

组别	n	肝、脾大	贫血	血小板计数减少	转氨酶水平升高	低蛋白血症	胸部X射线摄片结果异常	白细胞计数升高
单纯CS组	39	13(33.3)	15(38.4)	4(10.3)	17(43.6)	8(20.5)	21(53.8)	29(74.4)
合并TORCH组	36	24(66.7)	23(63.9)	13(36.1)	34(94.4)	19(52.8)	32(88.9)	27(75.0)
校正χ²	?	8.321	4.842	7.139	22.249	8.458	11.090	0.004
P	?	0.004	0.028	0.008	0.000	0.004	0.001	0.949
组别	n	胆红素升高	低出生体重儿	产时窒息	皮疹	颅内出血	尿常规异常
单纯CS组	39	13(33.3)	9(23.1)	6(15.4)	19(48.7)	4(10.3)	7(17.9)
合并TORCH组	36	13(36.1)	14(38.9)	11(30.6)	19(52.8)	8(22.2)	12(33.3)
校正χ²	?	0.064	2.201	2.458	0.123	1.994	2.342
P	?	0.801	0.138	0.117	0.725	0.158	0.126

表3 2组转氨酶升高水平比较(U)

Table 3 Comparison of transaminase levels of two groups(U)

组别	ALT			AST
组别	P₂₅	P₅₀	P₇₅	P₂₅	P₅₀	P₇₅
单纯CS组	95.3000	105.0000	156.6000	99.0000	113.2000	154.9000
合并TORCH组	95.0000	166.0000	300.0000	135.9000	316.0000	443.0000
Z	－14.948			－40.079
P	0.000			0.000

表3 2组转氨酶升高水平比较(U)

Table 3 Comparison of transaminase levels of two groups(U)

组别	ALT			AST
组别	P₂₅	P₅₀	P₇₅	P₂₅	P₅₀	P₇₅
单纯CS组	95.3000	105.0000	156.6000	99.0000	113.2000	154.9000
合并TORCH组	95.0000	166.0000	300.0000	135.9000	316.0000	443.0000
Z	－14.948			－40.079
P	0.000			0.000

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