Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2013, Vol. 09 ›› Issue (03): 337 -343. doi: 10.3877/cma.j.issn.1673-5250.2013.03.013

Special Issue:

Original Article

Epidemiological Study on Thalassaemia Among the Children Under 7 Years Old From Yunnan Province With Unique Ethnic Minority Origin

Li-qin YAO1, Tuan-biao ZOU1, Jin-tao LIU1, Xing QUAN1, Qian CHEN1, Fa-bin YANG1, Li-sha HU1, Xing-tian WANG1, Zhong-ming ZHAO1()   

  1. 1. Yunnan Provincial Maternal and Child Health Hospital, Kunming 650051, Yunnan Province, China
  • Received:2012-12-03 Revised:2013-04-01 Published:2013-06-01
  • Corresponding author: Zhong-ming ZHAO
  • About author:
    (Corresponding author: ZHAO Zhong-ming, Email: )
Objective

To investigate the epidemiological status of Thalassaemia among the children under 7 years old from Yunnan province with 15 unique ethnic minority.

Methods

From June 2009 to September 2011, blood samples from 14 088 children were tested by blood cell automatic analysis, hemoglobin electrophoresis, and genetic analysis. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Yunnan Provincial Maternal and Child Health Hospital. Informed consent was obtained from all participates' parents.

Results

The incidence rates of Thalassaemia, β-Thalassemia and α-Thalassemia were 20.9%(1793/8559), 11.3%(964/8559), and 9.7%(829/8559), respectively. Significant difference were also detected among children from different ethnic groups as well as regions. The detection rate of Thalassaemia of border areas was higher than that of non-border areas. The highest detection rate of all the regions was 43.1% in Dehong city, followed by 33.7% in Xishuangbanna, 26.3% in Nujiang, 10.7% in Lincang, 9.8% in Baoshang.

Conclusions

Occurrence of Thalassemia varies substantially between different ethnic groups as well as regions, especially Southwestern areas. This study may provide a valuable basis for counseling of Thalassemia in Yunnan province.

表1 各民族7岁以下儿童血液样本抽样范围、地点及样本量
Table 1 The general information of children under 7 years old among different ethnics
表2 地中海贫血患者的血红蛋白电泳分析结果[n(%)]
Table 2 Results of hemoglobin electrophoresis of Thalassaemia among 8559 cases[n(%)]
表3 不同地区同一民族地中海贫血分析结果[n(%)]
Table 3 Results of Thalassaemia in different parts of the same ethnic
表4 不同民族的地中海贫血的血红蛋白电泳分析结果[n(%)]
Table 4 Results of hemoglobin electrophoresis of Thalassaemia of different nationalities[n(%)]
表5 云南省10州(市)地中海贫血、G6PD缺乏症发病率与地理气候的情况
Table 5 Situation among Thalassaemia, G6PD, geography and climate of Yunnan Province
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