Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children

Please choose a citation manager

Content to export

doi:10.3877/cma.j.issn.1673-5250.2013.02.022

Objective

To explore the clinical effect of naloxone to severe pneumonia complicated with heart failure in children.

Methods

From October 2010 to October 2011, 65 children with severe pneumonia complicated with heart failure were included in the study, and randomly divided into observation group(n=32) and control group(n=33). Basic treatment were given in both groups, and naloxone was given in observation group for treatment too. The symptoms and positive signs recovery time and effective rate were observed. There was no significant difference between two groups in age, sex, symptoms, lab results (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First People's Hospital of Shangqiu.Informed consent was obtained from each parents.

Results

There had significant differences in symptoms and positive signs recovery time between two groups(P<0.05). There also had significant difference in effective rate between two groups(P<0.05).

Conclusions

Naloxone has a significant clinical effect to severe pneumonia complicated with heart failure in children, and it can effectively shorten the course of the disease.

Key words: child, severe pneumonia, heart failure, naloxone

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

[1]	Xia YB. Clinical analysis of infants with severe pneumonia complicated with heart failure[J]. Jilin Med, 2012(6):1255.
[2]	Foldes FF, Davidson GM, Duncalf D, et al. The respiratory, circulatory, and analgesic effects of naloxone-narcotic mixtures in anaesthetized subjects[J]. Can Anaesth Soc J, 1965, 12(6):608-621.
[3]	Blumberg H, Dayton HB, Wolf PS. Counteraction of narcotic antagonist analgesics by the narcotic antagonist naloxone[J]. Proc Soc Exp Biol Med, 1966, 123(3):755-758.
[4]	Yuan W, Williams BN. Naloxone successfully counters life-threatening toxicity of benzodiazepine in a patient in methadone-maintenance treatment[J].J Neuropsychiatry Clin Neurosci, 2012, 24(3):10015-10016.
[5]	Tarsi G, Paradossi U, Tartuferi L, et al. Effects of naloxone on plasma levels of atrial natriuretic factor and noradrenaline during water load in moderate heart failure[J].G Ital Cardiol, 1996, 26(8):879-885.
[6]	Shen XM, Wang WP, ed.Pediatrics. 7th ed[M]. Beijing: People's Medical Publishing House, 2008. 275.
[7]	Yang HW. The clinical observation of naloxone in the treatment of children with severe pneumonia[J]. Med Rev, 2012, 5(8):34-38.
[8]	Zhang F. The clinical effcacy of naloxone and dexamethasone treating on the neonatal patients with severe pneumonia and heart failure[J]. China Med, 2003, 5(4):147-149.
[9]	Tong YQ, Cheng XY, Zhao XJ. The clinical observation of naloxone in the treatment of children with severe pneumonia[J]. J Pract Med Tech, 2005, 12(22):3365-3366.
[10]	Qian PD, Zhang SD. Naloxone in neonatal diseases[J]. Chin J Pediatr, 2001, 6(3):183-184.

[1]	Hongyu Tao, Jingjing Ye, Jin Yu, Xiuzhen Yang, Jingjing Qian, Bin Xu, Weize Xu, Qiang Shu. Value of contrast transthoracic echocardiography in assessing right-to-left shunt-related diseases in children[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2024, 21(10): 959-965.
[2]	Yigang Wu, Yumin Pan, Shanshan Wu, Mengjuan Hu, Yiwei Wang, Jinsong Zhang, Li Qiao. Efficacy of levosimendan in the treatment of pulmonary hypertension combined with right heart failure: a meta-analysis[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(05): 385-391.
[3]	Lie Zhang, Yihe Yan, Jieyu Du. Predictive efficacy of secretory leukocyte protease inhibitor in severe pneumonia patients with non-invasive ventilation[J]. Chinese Journal of Critical Care Medicine(Electronic Edition), 2024, 17(04): 301-306.
[4]	Xiaofei Li, Hongli Liu, Qiuling Shi, Jing Tian, Li Li, Hongbo Qi, Xin Luo. A prospective randomized controlled study of low intensity focused ultrasound uterine involution treatment for prevention and treatment of postpartum hemorrhage in natural childbirth women[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 534-539.
[5]	Qin Liu, Hanmin Liu, Liang Xie. Current status of research on the role of matrix metalloproteinases in the pathogenesis of childhood asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 564-568.
[6]	Yun Xiang, You Lu, Fan Yang. Current research status of correlation between per-and polyfluoroalkyl substances exposure and childhood obesity[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(05): 569-574.
[7]	Yuxiao Zhang, Fan Yang, Meng Mao. Interpretation of Catch-Up Growth in Infants and Young Children with Faltering Growth：Expert Opinion to Guide General Clinicians[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(04): 361-366.
[8]	Mengsi Zhang, Yiqun Ma, Lijuan Meng, Hui Zhu, Jinfeng Fu. Observation on the effect of the combined use of pressure gloves, webbed finger compression straps and foam silicone gel sheeting after surgery in children with cicatricial syndactyly[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(04): 329-334.
[9]	Xiaoli Yang, Wanfu Li, Zhu Ma, Lan Ma, Yi Zheng, Xiaoli Fu, Jing Wang. Application effect of one-step forceps needle method in laparoscopic high ligation of hernia sac in children[J]. Chinese Journal of Operative Procedures of General Surgery(Electronic Edition), 2024, 18(05): 535-538.
[10]	Hebei Ding, Xun Wang, Weiguo Chen. Comparison of application of sevoflurane inhalation anesthesia and propofol intravenous anesthesia in pediatric indirect inguinal hernia surgery[J]. Chinese Journal of Hernia and Abdominal Wall Surgery(Electronic Edition), 2024, 18(05): 570-574.
[11]	Chinese Society of Organ Transplantation of Chinese Medical Association, Surgery Group of Chinese Society of Surgery of Chinese Medical Association, Transplantation Group of Chinese Society of Surgery of Chinese Medical Association, South China Alliance of Split Liver Transplantation. Chinese Clinical Practice Guidelines on Split Liver Transplantation in Children[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 593-601.
[12]	Jun Liu, Wenjing Qiu, Fanghao Sun, Songying Li, Shuhong Yi, Binsheng Fu, Yang Yang, Hui Luo. Comparison of in vivo and in vitro split liver transplantation in pediatric liver transplantation[J]. Chinese Journal of Hepatic Surgery(Electronic Edition), 2024, 13(05): 688-693.
[13]	Chen Zhang, Ming Qin, Juan Dong, Yulong Chen. Diagnostic value of ultrasound in ischemic changes of intestinal volvulus in children[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 565-568.
[14]	Xiaosheng Chen, Jia He, Fang Liu, Rui Wu, Haitao Yang, Xiaohan Fan. Pacemaker implantation in a child with a 31-second cardiac arrest induced by tilt table test: a case report and literature review[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 488-494.
[15]	Yali Cao, Yumeng Gao, Yingqian Zhang, Bo Li, Junbao Du, Hongfang Jin. Clinical progress of sitting intolerance in children[J]. Chinese Journal of Cerebrovascular Diseases(Electronic Edition), 2024, 18(05): 510-515.

Viewed

Full text

Abstract

Just accepted	Online first	Issue

0	0	19

From	Others	local

Times	12	7
Rate	63%	37%

Just accepted

Online first

Just accepted

Online first