Clinical Effect of Naloxone Treatment to Severe Pneumonia Complicated With Heart Failure in Children

doi:10.3877/cma.j.issn.1673-5250.2013.02.022

Objective

To explore the clinical effect of naloxone to severe pneumonia complicated with heart failure in children.

Methods

From October 2010 to October 2011, 65 children with severe pneumonia complicated with heart failure were included in the study, and randomly divided into observation group(n=32) and control group(n=33). Basic treatment were given in both groups, and naloxone was given in observation group for treatment too. The symptoms and positive signs recovery time and effective rate were observed. There was no significant difference between two groups in age, sex, symptoms, lab results (P>0.05). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First People's Hospital of Shangqiu.Informed consent was obtained from each parents.

Results

There had significant differences in symptoms and positive signs recovery time between two groups(P<0.05). There also had significant difference in effective rate between two groups(P<0.05).

Conclusions

Naloxone has a significant clinical effect to severe pneumonia complicated with heart failure in children, and it can effectively shorten the course of the disease.

Key words: child, severe pneumonia, heart failure, naloxone

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表1 两组患儿症状和阳性体征缓解时间比较(d，±s)

Table 1 Comparison of positive signs and symptoms recovery time between two groups(d，±s)

组别	n	体温缓解时间	呼吸急促缓解时间	面色发绀缓解时间	心动过速缓解时间	肝脏肿大缓解时间
观察组	33	1.52±0.60	2.43±0.66	2.56±1.01	2.35±0.92	2.62±0.90
对照组	32	2.21±0.72	3.39±0.98	3.21±0.87	3.28±0.73	3.29±1.07
t		2.18	2.73	2.88	3.15	2.44
P		<0.05	<0.01	<0.01	<0.01	<0.05

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

表2 两组患儿治疗5 d时疗效比较[n(%)]

Table 2 Comparison of curative effect between two groups at the fifth day after therapy[n(%)]

组别	n	疗效			有效率
组别	n	治愈	好转	无效	有效率
观察组	33	22(66.7)	8(24.2)	3 (9.1)	30(90.9)
对照组	32	15(46.9)	9(28.1)	8(25.0)	24(75.0)
χ²					13.47
P					<0.01

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