Effects of Recombinant Human Growth Hormone on Stature in Short Children Born Small for Gestational Age

doi:10.3877/cma.j.issn.1673-5250.2012.05.007

Objective

To explore the therapeutic effects of recombinant human growth hormone (rhGH)on children with short stature born small for gestational age (SGA).

Methods

This was a prospective observational study with institutional ethics approval and written maternal consent. A total of 20 children with short stature born in SGA were selected in Department of Pediatrics, Sichuan Provincial People's Hospital and West China Second Hospital, Sichuan University from January 2008 to October 2011. Their average age was (8.95±4.06) years old. Each child was treated with rhGH by subcutaneous injection every night before sleep, and the dosage was (0.15-0.20) U/(kg·d) for 2.3-18.0 months. The height (Ht), height standard deviation score (HtSDS)and height velocity (HV) were statistically analyzed before and after rhGH treatment.

Results

Before and after rhGH treatment, there had significant differences in the Ht[(110.34±22.1) cm vs.(115.88±22.29) cm], HtSDS (-4.31±1.47 vs. -3.71±1.36)and HV[(4.06±0.6) cm/year vs. (9.86±4.01)cm/year](P<0.05).

Conclusions

rhGH can play a significant role in promoting growth of children with short stature born in SGA.

Key words: small for gestational age, recombinant human growth hormone, stature, child

表1 20例身材矮小SGA儿的rhGH治疗疗效(±s)

Table 1 Comparison of Ht, HtSDS and HV before and after rhGH treatment (±s)

时间	Ht(cm)	HtSDS	HV(cm/年)
治疗前	110.34±22.10	－4.31±1.47	4.06±0.61
治疗后	115.88±22.29	－3.71±1.36	9.86±4.01
t	－5.083	－3.972	－5.834
P	<0.01	<0.01	<0.01

表1 20例身材矮小SGA儿的rhGH治疗疗效(±s)

Table 1 Comparison of Ht, HtSDS and HV before and after rhGH treatment (±s)

时间	Ht(cm)	HtSDS	HV(cm/年)
治疗前	110.34±22.10	－4.31±1.47	4.06±0.61
治疗后	115.88±22.29	－3.71±1.36	9.86±4.01
t	－5.083	－3.972	－5.834
P	<0.01	<0.01	<0.01

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