Analysis of Human Papillomavirus Infection and Its Related Factors Among 508 Women

doi:10.3877/cma.j.issn.1673-5250.2012.04.009

Objective

To investigate prevalence, genotypes distribution and related infection factors of human papillomavirus (HPV) in order to provide scientific evidence for the prevention and control of HPV infection.

Methods

From January 2009 to December 2010, a total of 508 women who received cervical HPV testing in Second Affiliated Hospital of Qingdao University Medical College were included into this study. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Second Affiliated Hospital of Qingdao University Medical College. After obtaining specimens of cervical cytology, rapid flow-through hybridization technique (namely Hybribio flow-through hybridization) was used to detect HPV genotypes simultaneously. Multiple factors non-conditional logistic regression analytic method was used to discuss the relationship between HPV infection and related factors (age, educational level, initial age for sex, number of pregnancy termination, number of sexual partners, number of spouse's sexual partners, smoking history and contraception measures).

Results

Among 508 women received HPV infection test, the total HPV infection rate was 22.05% (112/508), including the high-risk HPV (HR-HPV) subtypes infection rate was 18.90% (95/508), the low-risk HPV (LR-HPV) subtypes infection rate was 2.17%(11/508), the most common type of Chinese was 1.18% (6/508). The top five high-risk subtypes were HPV-16(7.68%), -52(4.72%), -58(3.74%), -18(3.15%), -31(2.36%). The relative factors of HPV infection in 508 women were initial age for sex, number of sexual partners, number of spouse's sexual partners, number of pregnancy termination and smoking history (χ²=105.539, 5.092, 37.158, 5.076, 13.824, respectively, P<0.05). Multiple factor non-conditional Logistic regression model analysis showed that the independent factors were initial age for sex (OR=13.036), number of sexual partners (OR=5.860), number of spouse's sexual partners (OR=2.120), and smoking history (OR=2.054).

Conclusions

The independent risk factors for HPV infection in women are bad living habits and bad sexual behavior. Changing bad living habits and bad sexual behavior are effective ways to prevent HPV infection.

Key words: human papillomavirus, infection rate, genotypes distribution, related factors

表1 本组患者HPV感染类型分布[n(%)]

Table 1 Distribution of HPV infection types of all the subjects [n(%)]

HPV类型		HPV感染率
HR－HPV		?
?	HPV－16	39(7.68)
?	HPV－52	24(4.72)
?	HPV－58	19(3.74)
?	HPV－18	16(3.15)
?	HPV－31	12(2.36)
?	HPV－33	6(1.18)
?	HPV－68	6(1.18)
?	HPV－56	5(0.98)
?	HPV－59	3(0.59)
?	HPV－35	1(0.20)
?	HPV－51	1(0.20)
LR－HPV		?
?	HPV－6	6(1.18)
?	HPV－11	4(0.79)
?	HPV－42	1(0.20)
常见亚型		?
?	HPV－53	4(0.79)
?	CP8304	2(0.39)

表1 本组患者HPV感染类型分布[n(%)]

Table 1 Distribution of HPV infection types of all the subjects [n(%)]

HPV类型		HPV感染率
HR－HPV		?
?	HPV－16	39(7.68)
?	HPV－52	24(4.72)
?	HPV－58	19(3.74)
?	HPV－18	16(3.15)
?	HPV－31	12(2.36)
?	HPV－33	6(1.18)
?	HPV－68	6(1.18)
?	HPV－56	5(0.98)
?	HPV－59	3(0.59)
?	HPV－35	1(0.20)
?	HPV－51	1(0.20)
LR－HPV		?
?	HPV－6	6(1.18)
?	HPV－11	4(0.79)
?	HPV－42	1(0.20)
常见亚型		?
?	HPV－53	4(0.79)
?	CP8304	2(0.39)

表2 HPV感染因素的单因素分析[n(%)]

Table 2 Univariate analysis of factors of HPV infection[n(%)]

相关因素		n	HPV感染率	χ²	P
年龄(岁)		?	?	?	?
?	20～30	56	9(16.1)	3.433	0.330
?	30～40	204	52(25.5)	?	?
?	40～50	169	37(21.9)	?	?
?	>50	79	14(17.7)	?	?
文化程度		?	?	?	?
?	<大专	165	42(25.5)	1.651	0.210
?	≥大专	343	70(20.4)	?	?
初次性生活年龄(岁)		?	?	?	?
?	≤20	81	53(65.4)	105.539	0.000
?	>20	427	59(13.8)	?	?
配偶性伴侣数(个)		?	?	?	?
?	1	407	67(16.5)	37.158	0.000
?	≥2	101	45(44.6)	?	?
性伴侣数(个)		?	?	?	?
?	1	359	69(19.2)	5.092	0.019
?	≥2	149	43(28.9)	?	?
流产次数(次)		?	?	?	?
?	0～2	344	66(19.2)	5.076	0.029
?	≥3	164	46(28.0)	?	?
吸烟史		?	?	?	?
?	是	123	42(34.1)	13.824	0.000
?	否	385	70(18.2)	?	?
避孕方式		?	?	?	?
?	避孕套	206	48(23.3)	3.066	0.094
?	非避孕套	302	64(21.2)	?	?

表2 HPV感染因素的单因素分析[n(%)]

Table 2 Univariate analysis of factors of HPV infection[n(%)]

相关因素		n	HPV感染率	χ²	P
年龄(岁)		?	?	?	?
?	20～30	56	9(16.1)	3.433	0.330
?	30～40	204	52(25.5)	?	?
?	40～50	169	37(21.9)	?	?
?	>50	79	14(17.7)	?	?
文化程度		?	?	?	?
?	<大专	165	42(25.5)	1.651	0.210
?	≥大专	343	70(20.4)	?	?
初次性生活年龄(岁)		?	?	?	?
?	≤20	81	53(65.4)	105.539	0.000
?	>20	427	59(13.8)	?	?
配偶性伴侣数(个)		?	?	?	?
?	1	407	67(16.5)	37.158	0.000
?	≥2	101	45(44.6)	?	?
性伴侣数(个)		?	?	?	?
?	1	359	69(19.2)	5.092	0.019
?	≥2	149	43(28.9)	?	?
流产次数(次)		?	?	?	?
?	0～2	344	66(19.2)	5.076	0.029
?	≥3	164	46(28.0)	?	?
吸烟史		?	?	?	?
?	是	123	42(34.1)	13.824	0.000
?	否	385	70(18.2)	?	?
避孕方式		?	?	?	?
?	避孕套	206	48(23.3)	3.066	0.094
?	非避孕套	302	64(21.2)	?	?

表3 HPV感染相关因素的多因素非条件logistic回归分析

Table 3 Logistic regression analysis of the relative factors of HPV infection

变量	β_j	S_b	χ²	P	OR	95%CI
初次性生活年龄	2.568	0.319	64.912	0.000	13.036	6.980～24.347
性伴侣数	1.768	0.276	41.010	0.000	5.860	3.411～10.067
配偶性伴侣数	0.751	0.299	6.318	0.012	2.120	1.180～ 3.808
吸烟史	0.720	0.298	5.816	0.016	2.054	1.144～ 3.686

表3 HPV感染相关因素的多因素非条件logistic回归分析

Table 3 Logistic regression analysis of the relative factors of HPV infection

变量	β_j	S_b	χ²	P	OR	95%CI
初次性生活年龄	2.568	0.319	64.912	0.000	13.036	6.980～24.347
性伴侣数	1.768	0.276	41.010	0.000	5.860	3.411～10.067
配偶性伴侣数	0.751	0.299	6.318	0.012	2.120	1.180～ 3.808
吸烟史	0.720	0.298	5.816	0.016	2.054	1.144～ 3.686

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