Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2022, Vol. 18 ›› Issue (05): 512 -516. doi: 10.3877/cma.j.issn.1673-5250.2022.05.003

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Research progress on circular RNA in pathogenesis of cervical cancer

Yimiao Wei, Yaqin Li, Weihong Zhao()   

  1. Department of Obstetrics and Gynecology, Second Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China
  • Received:2022-01-30 Revised:2022-09-06 Published:2022-10-01
  • Corresponding author: Weihong Zhao
  • Supported by:
    National Natural Science Foundation of China(81702583); China Postdoctoral Science Foundation Project(2019M651072); Applied Basic Research Program of Shanxi Province(201901D211506)

Cervical cancer is one of the most common gynecological malignancies, and its morbidity and mortality both rank fourth in the world. It is now clear that the occurrence and development of cervical cancer are related to persistent infection with high risk-human papillomavirus (HR-HPV). Circular RNA (circRNA) is a new type of endogenous non-coding RNA (ncRNA), compared with other types of RNA, the three main characteristics of circRNA are evolutionary conservation, structural stability and tissue specificity. Different kinds of circRNA are abnormally expressed in cervical cancer and can participate in proliferation, migration and invasion of cervical cancer cells by regulating their corresponding binding elements, thereby playing an important role in the occurrence and development of cervical cancer. In this paper, the biological functions of circRNA and latest researches on its role of cervical cancer pathogenesis are reviewed, so as to provide a new target for the diagnosis and treatment of cervical cancer.

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