Vaginal microenvironmental imbalance and persistent infection with high-risk human papillomavirus

doi:10.3877/cma.j.issn.1673-5250.2021.06.017

Objective

To investigate relationship between vaginal microecological imbalance and persistent high-risk human papillomavirus (HR-HPV) infection.

Methods

From January 2014 to December 2015, a total of 240 patients, aged 19-73 years old, diagnosed with HR-HPV infection in Department of Gynecology, Science City Hospital of Sichuan. According to HR-HPV infection statuses, they were divided into study group (n=121, those who with persistent HR-HPV infection) and control group (n=119, those who with negative HR-HPV retest). Independent-samples t test was used to statistically analyze weight, body mass index (BMI), gravidity and parity between two groups. The incidence of bacterial vaginosis (BV), vulvovaginal pseudo vaginosis (VVC), trichomoniasis vaginosis (TV), and aerobic vaginitis (AV) between 2 groups were statistically analyzed by chi-square test. The procedures followed in this study were in accordance with the requirements of the World Medical Association Declaration of Helsinki revised in 2013.

Results

① There were no statistically significant differences in general clinical data such as weight, BMI, gravidity and parity between 2 groups (P>0.05). ②The detection rates of BV and VVC in study group were 43.0% (52/121) and 38.0% (46/121), respectively, which were significantly higher than those 20.2% (24/119) and 15.1% (18/119) in control group, and differences were statistically significant (χ²=14.422, 16.075; P=0.002, <0.001). Besides, the differences were not statistically significant in detection rates of TV, AV between 2 groups (P>0.05).

Conclusions

BV and VVC are closely associated with persistent HR-HPV infection, and improving the vaginal microecological environment may help to reduce the incidence of HR-HPV.

Key words: Vagina, Human papillomavirus, Infection, Vaginosis, bacterial, Candidiasis, vulvovaginal, Trichomonas vaginitis, Female

表1 2组患者一般临床资料比较(±s)

组别	例数	体重(kg)	BMI(kg/m²)	孕次(次)	产次(次)
研究组	121	61.1±6.5	23.7±2.0	2.12±0.03	1.31±0.03
对照组	119	61.0±6.3	23.5±2.4	2.15±0.01	1.33±0.02
t值		0.121	0.702	<0.001	<0.001
P值		0.452	0.242	0.999	0.999

表1 2组患者一般临床资料比较(±s)

组别	例数	体重(kg)	BMI(kg/m²)	孕次(次)	产次(次)
研究组	121	61.1±6.5	23.7±2.0	2.12±0.03	1.31±0.03
对照组	119	61.0±6.3	23.5±2.4	2.15±0.01	1.33±0.02
t值		0.121	0.702	<0.001	<0.001
P值		0.452	0.242	0.999	0.999

表2 2组患者阴道分泌物检测异常情况比较[例数(%)]

组别	例数	BV	VVC	TV	AV	混合性感染
研究组	121	52(43.0)	46(38.0)	13(10.7)	19(15.7)	15(12.4)
对照组	119	24(20.2)	18(15.1)	10(8.4)	10(8.4)	10(8.4)
χ²值		14.422	16.075	0.379	3.009	1.025
P值		0.002	<0.001	0.538	0.083	0.311

表2 2组患者阴道分泌物检测异常情况比较[例数(%)]

组别	例数	BV	VVC	TV	AV	混合性感染
研究组	121	52(43.0)	46(38.0)	13(10.7)	19(15.7)	15(12.4)
对照组	119	24(20.2)	18(15.1)	10(8.4)	10(8.4)	10(8.4)
χ²值		14.422	16.075	0.379	3.009	1.025
P值		0.002	<0.001	0.538	0.083	0.311

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