Infertile Factors Associated With Abortion in Nonparous Women

doi:10.3877/cma.j.issn.1673-5250.2012.01.009

Objective

To study the difference between primary and postabortal (spontaneous, medical or artificial abortion) infertile women.

Methods

From January 2007 to December 2009, 1753 women who underwent the treatment of in vitro fertilization and embryo transfer (IVF-ET) were included in the study, and were divided into postabortal infertile group (n=706) and primary infertile group (n=1047). The general characteristics and infertile factors were analyzed in both groups. The study protocol was approved by the Ethical Review Board of Investigation in Human Being of First Affiliated Hospital of Nanjing Medical University.Informed consent was obtained from each patient. There had no significant difference in age between two groups(P>0.05).

Results

The duration of infertility in postabortal infertile group was shorter than that in primary infertile group (P<0.05). There was no significant difference in body mass index (BMI) between two groups (P>0.05). The education level of patients in postabortal infertile group was significantly lower than that in primary infertile group(P<0.01). Comparing to primary infertile group, the incidence of the tubal infertility was much higher than that in postabortal infertile group (P<0.001). However, the incidence of infertility with ovulation failure, endometriosis, uterine and other factors in postabortal infertile group were significantly lower than those in primary infertile group (P<0.001).

Conclusions

The tubal factor was the major factor in the postabortal infertile women, especially those who with little education experience. We should pay more attention to the nonparous women and provide necessary information on reproductive health to them in order to decrease the incidence of infertility due to the unplanned pregnancy and abortion.

Key words: infertility, etiology, spontaneous, medical or artificial abortion, in vitro fertilization and embryo transfer

表1 两组一般资料比较(±s)

Table 1 Comparison of general data between two groups(±s)

组别	n	不孕年限(年)	BMI(kg/m²)	文化程度[n(%)]
组别	n	不孕年限(年)	BMI(kg/m²)	初中及以下	高中	大学及以上
流产后不孕组	706	5.09±3.56	21.64±2.52	2(31.16)	258(36.54)	228(32.29)
原发不孕组	1047	5.60±3.56	21.77±2.57	313(29.89)	296(28.27)	438(41.83)
P	?	<0.05	>0.05	<0.001	<0.001	<0.001

表1 两组一般资料比较(±s)

Table 1 Comparison of general data between two groups(±s)

组别	n	不孕年限(年)	BMI(kg/m²)	文化程度[n(%)]
组别	n	不孕年限(年)	BMI(kg/m²)	初中及以下	高中	大学及以上
流产后不孕组	706	5.09±3.56	21.64±2.52	2(31.16)	258(36.54)	228(32.29)
原发不孕组	1047	5.60±3.56	21.77±2.57	313(29.89)	296(28.27)	438(41.83)
P	?	<0.05	>0.05	<0.001	<0.001	<0.001

表2 两组不孕病因比较[n(%)]

Table 2 Comparison of infertile factors between two groups[n(%)]

不孕病因	流产后不孕组		原发不孕组
不孕病因	n	构成比(%)	n	构成比(%)
输卵管因素	568	80.45	631	60.27
排卵因素	42	5.95	157	15.00
子宫内膜异位症	36	5.10	138	13.18
子宫及其他因素(包括免疫因素及不明原因)	60	8.50	121	11.56
总计	706	100.00	1047	100.01

表2 两组不孕病因比较[n(%)]

Table 2 Comparison of infertile factors between two groups[n(%)]

不孕病因	流产后不孕组		原发不孕组
不孕病因	n	构成比(%)	n	构成比(%)
输卵管因素	568	80.45	631	60.27
排卵因素	42	5.95	157	15.00
子宫内膜异位症	36	5.10	138	13.18
子宫及其他因素(包括免疫因素及不明原因)	60	8.50	121	11.56
总计	706	100.00	1047	100.01

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