Analysis of 123 Children of Idiopathic Thrombocytopenic Purpura Combined With Helicobacter Pylori Infection

doi:10.3877/cma.j.issn.1673-5250.2011.02.007

Objective

To explore the relationship between idiopathic thrombocytopenic purpura (ITP) and Helicobacter pylori (HP) infection in children.

Methods

From August 2006 to April 2010, a total of 123 children were included into this study, who were diagnosed as idiopathic thrombocytopenic purpura by clinical characters and bow marrow cells examinations. Serum Helicobacter pylori antibodies and soluble-Helicobacter pylori (S-HP) antigen were measured by immune blotting method (Western Blot). The study protocol was approved by the Ethical Review Board of Investigation in Human Being of Kunming Children's Hospital. Informed consent was obtained from all participants.

Results

The results showed 50 (40.7%) cases accompanied with Helicobacter pylori infection among 123 patients with idiopathic thrombocytopenic purpura. The main serum antibody types of Helicobacter pylori infection in 50 Helicobacter pylori-positive patients with idiopathic thrombocytopenic purpura included anti-UreB, anti-VacA, anti-CagA and all with soluble-Helicobacter pylori antigen. The glucocorticoid combined with Helicobacter pylori eradication was effective therapy for the idiopathic thrombocytopenic purpura combined with Helicobacter pylori infection.

Conclusion

The pathogenesis of idiopathic thrombocytopenic purpura may related with Helicobacter pylori infection.

Key words: child, idiopathic thrombocytopenic purpura (ITP), Helicobacter pylori infection

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