Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (04): 373 -376. doi: 10.3877/cma.j.issn.1673-5250.2009.04.110

Original Article

Captopril and Losartan Intervention Change the Zero-Stress State of the Pulmonary Artery in Rats With Pulmonary Arterial Hypertension

Xian-min WANG, Kui ZHANG, Xiao-qin WANG, Bin LIU, Li WEI, Han-min LIU, Tong-fu ZHOU   

  1. Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, Chengdu 610041, China
  • Published:2009-08-01
Objective

To observe the opening angle of rats' pulmonary artery and explore effects of captopril and losartan on the zero-stress state of the pulmonary artery in rats with pulmonary artery hypertension(PAH).

Methods

Forty male Spraque-Dawley rats were average divided into 4 groups randomly which included the pulmonary artery hypertension (created by pneumonectomy plus MCT injection) model group(PM group), PAH model treated with captopril [captopril group, 10 mg/(kg·d)] or losartan [(losartan group, 15 mg/(kg·d)] and normal control(control group). Mean pulmonary arterial pressure (mPAP), weight ratio of RV to LV+ S were measured at day 35. Meanwhile, the zero-stress state characterized by opening angle of the pulmonary arterial was observed by an image processing system.

Results

Mean pulmonary artery pressure and RV/(LV+ S) in PM group [(39.62±1.46) mm Hg, (62.66±0.61)%] increased significantly than those of captopril group [(24.38±1.19) mm Hg, (48.82±1.12)%], losartan group [(23.95±0.97)mm Hg, (49.15±1.41)%], and control group [(17.62±1.12) mm Hg, (26.86±0.96)%] (P<0.001). Opening angle in PM group [(79.13±4.19)°] decreased significantly than those of captopril group[(103.63±5.69)°], losartan group [(102.91±5.77)°], and control group[(139.17±4.27)°] (P<0.001). Mean pulmonary artery pressure, RV/(LV+ S) and opening angle in captopril group and losartan group had no significant difference (P>0.05).

Conclusion

Captopril and losartan induced attenuation of pulmonary artery pressure and associated pulmonary vascular remodeling are likely related to their action on the regulation of the zero-stress state of the pulmonary artery in rats.

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