Clinic Study on the Change Tendency of Platelet Count in Healthy Pregnant Women.

doi:10.3877/cma.j.issn.1673-5250.2009.03.108

Objective

To investigate the change tendency of platelet(PLT) count in healthy pregnant women, and study the correlation between platelet count and postpartum hemorrhage, and perinatal outcomes.

Methods

From July 2006 to June 2007, the clinical data of 2 655 healthy pregnant women who delivered in the West China Second University Hospital, Sichuan University were investigated retrospectively.

Results

① The reference value of platelet count >80×10⁹/L for the healthy pregnant women. The platelet count decreased during normal pregnancy. ② The incidence of gestational thrombocytopenia (GT) of healthy pregnant women before delivering was 22.29%. ③ There were no significant correlation between platelet count and the gravidity, parity, age, and occupation (P>0.05). ④ There were no significant difference between groups compared with volume of bleeding during caesarean section and vaginal delivery(P>0.05). Platelet transfusion could decrease bleeding volume during caesarean section. ⑤ There were no significant correlation between platelet count and perinatal outcomes(P>0.05).

Conclusion

The incidence of gestational thrombocytopenia is high. But there are no significant correlation between platelet count and perinatal outcomes. Platelet transfusion can reduce bleeding volume in caesarean section.

Key words: pregnancy, platelet count, gestational thrombocytopenia

图1　孕期血小板变化趋势

	1 Emest B. Williams hematology. 6 th ed. Song SJ, Chen Y, trans. Beijing: People's Medical Publishing House, 2003, 1586–1587.[Emest B. 威廉姆斯血液学. 第6版. 宋善俊，陈燕，主译. 北京：人民卫生出版社，2003, 1586–1587.]
	2　Yue J, ed. Obstetrics and gynecology. 7 th ed. Beijing: People's Medical Publishing House, 2008, 205–208.[乐杰，主编. 妇产科学. 第7版. 北京：人民卫生出版社，2008，205–208.]
	3　Faridi AW. Differential diagnosis of thrombocytopenia in pregnancy. Zentralbl Gynakol, 2001, 123(2)：80–90.
	4　Yang JQ, Ma LK, Gai MY, et al. Clinical analysis of idiopathic thrombocytopenic purpura with pregnancy. Chin J Obstet Gynecol, 2001, 36(6): 333–335.[杨剑秋，马良昆，盖铭英，等. 特发性血小板减少性紫癜合并妊娠的临床分析. 中华妇产科杂志，2001，36(6)：333–335.]
	5　British Committee for Standards in Hematology General Hametological Task Force. Guidelines for the investigation and management of idiopathic thrombocytopenic purpura in adults, children and in pregnancy. Br J Haematol, 2003, 120(4): 574–596.
	6　Kelton JG. Idiopathic thrombocytopenic purpura complicating pregnancy. Blood Rev, 2002, 16(1): 43–46.
	7　Liang MY, Wang JW. Clinical analysis of 40 cases of idiopathic thrombocytopenic purpura with pregnancy. Chin J Perinat Med, 2003, 6: 273–276.[梁梅英，王建文. 妊娠合并特发性血小板减少性紫癜40例临床分析. 中华围产医学杂志，2003，6：273–276.]
	8　Schwartz KA. Gestational thrombocytopenia and immune thrombocytopenias in pregnancy. J Hematol Oncol Clin North Am, 2000, 14(5): 1101–1116.
	9　Hua K, Zhou CH. The progress treatment of idiopathic thrombocytopenic purpura with pregnancy. J Int Obstet Gynecol, 2000, 27(1): 29–33.[华凯，周春华. 妊娠合并特发性血小板减少性紫癜处理的进展. 国外医学妇产科分册，2000，27(1): 29–33.]
	10　The American Society of Hematology ITP Practice Guideline Panel. Diagnosis and treatment of idiopathic thrombocytopenic purpura: Recommendations of the American Society of Hematology. Ann Int Med，1997, 126(4): 319–326.
	11　Sainio S，Joutsi L，Jarvenpaa AL, et al. Idiopathic thrompocytopenic purpura in pregnancy. Acta Obstet Gynecol Scand, 1998, 77(3): 272–277.
	12　Cao ZY. Chinese obstetrics and gynecology. 2 th ed. Beijing: People's Medical Publishing House, 2004, 622–624.[曹泽毅，主编. 中华妇产科学. 第2版. 北京：人民卫生出版社，2004，622–624.]
	13　Contreras M. The appropriate use of platelets: An update from the Edinburgh Consensus Conference. Br J Haematol, 1998, 101(Suppl 1): 10–21.
	14　Payne SD, Resnik R, Moore TR, et al. Maternal characteristics and risk of severe neonatal thrombocytopenia and intracranial homorrhage in pregnancies complicated by autoimmune thrombocytopenia. Am J Obstet Gynecol, 1997, 117 (1): 149–155.

[1]	Peipei Zhang, Hua Meng, Zihan Niu, Yunshu Ouyang, Yixiu Zhang, Xining Wu, Yuxin Jiang. Normal reference value of fetal bowel width during middle and late pregnancy[J]. Chinese Journal of Medical Ultrasound (Electronic Edition), 2023, 20(03): 288-291.
[2]	Haoyuan Yang, Jie Gong, Qingwei Zou, Hang Ruan. Current research status on adverse pregnancy outcomes of maternal and infant in pregnant women with asthma[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 522-529.
[3]	Tiantian Chen, Xiaodong Wang, Haiyan Yu. Pregnancy outcome of twin pregnancy with Gitelman syndrome: a case report and literature review[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 559-568.
[4]	Xiaoqing Ju, Yunjie Jin, Xiaoyan Wang. Influencing factors of uterine rupture during vaginal delivery in patients with scarred uterus after cesarean section[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 575-581.
[5]	Juan Gu, Qingqing Sun, Fangfang Hu, Yijuan Cao, Yujuan Qi. Clinical application of endometrial receptivity array to improve pregnancy outcomes in women with repeated embryo implantation failure[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 582-587.
[6]	Beibei Wang, Qixiu Dong, Hongyan Xi, Qingyun Yu, Lijun Zhang, Guang Shi. Analysis of influencing factors of medical abortion failure of pregnant women in early pregnancy and construction of related prediction model and its predictive value for medical abortion success[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 588-594.
[7]	Mengling Zhou, Zhiwei Xue, Shu Zhou. Changes in size of uterine myoma during pregnancy and its association with adverse pregnancy outcomes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(05): 611-615.
[8]	Chenxi Ran, Rufei Shen, Mingyu Liao, Qian Liao, Ling Zhou, Yuling Zhang, Min Long. Treatment and management of pituitary tumor during pregnancy[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2023, 19(04): 487-491.
[9]	Jinke Hu, Wen Zhong. Management and outcome of ureteral calculi in pregnancy[J]. Chinese Journal of Endourology(Electronic Edition), 2023, 17(04): 377-381.
[10]	Guohua Ren, Xiaoxiao Du, Shanling Hong, Shuai Shao. Change and significance of serum interleukin-22, hydrogen sulfide, and osteoprotegerin levels of patients with hypertensive acute kidney injury in pregnancy[J]. Chinese Journal of Kidney Disease Investigation(Electronic Edition), 2023, 12(03): 150-155.
[11]	Yuyan Zhang, Bin Hu, Weihong Zhang, Mei Xu, Hui Zhu, Xinyue Yang, Hailing Liu. Relationship between echocardiography parameters and liver function during the second trimester of pregnancy and their predictive value for adverse pregnancy outcomes[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2023, 13(06): 499-504.
[12]	Xin Wang, Lin Liu, Zhejia Wen, Chunling Liu, Hong Zhang, Fang Lyu. Effect of stress exposure before pregnancy on subsequent pregnancy outcomes in mice[J]. Chinese Journal of Clinicians(Electronic Edition), 2023, 17(04): 431-437.
[13]	Lizi Zhang, Dunjin Chen. Adverse outcomes and longterm prognosis of placenta accreta spectrum disorders[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(03): 155-158.
[14]	Wenshi Wu, Songquan Wei, Guimin Li, Xiaofang Zheng, Wen Sun, Dunjin Chen, Lin Yu. Outcomes of subsequent pregnancies after partial hysterectomy for placenta accreta spectrum[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2023, 12(03): 180-186.
[15]	Yanli Zou, Wenjie Luan, Shujuan Wang, Yaqin Liu, Guizhi Chu, Songyang Li, Haoling Wang, Jinting Zhang, Xin Jiang, Zedong Luan. Ultrasonographic features of fetal right aortic arch in the first trimester[J]. Chinese Journal of Diagnostics(Electronic Edition), 2023, 11(04): 227-232.

Viewed

Full text

Abstract

Please choose a citation manager

Content to export