Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (02): 146 -150. doi: 10.3877/cma.j.issn.1673-5250.2009.02.111

Original Article

Clinico-Serlogical Observation on the Tic Disorder and Pediatric Autoimmune Neuropsychiatric Disorder With Streptococcal Infections

Hui CHEN, You-quan ZHONG, Zhi-xu HE, Ju WU, Wen-zhi ZHOU, Ming-xia SUN   

  1. Chengdu children's Hospital, 610017, Chengdu, China
  • Published:2009-04-01
Objective

To explore the relationship between pediatric autoimmune neuropsychiatric disorder with streptococcal infections(PANDAS)and tic disorder(TD)from clinical serum research angle.

Methods

The titers of anti-streptococcal antibody(ASO, ADNB)and anti-basal ganglia antibodies(ABGA)were assaied by adoptlatex agglutination, micromethod and indirect immunofluorescence(IFL)in 80 tic disorder patients (who were diagnosed in the Department of Nerve-Spiritual, Chengdu Children's Hospital from March to June, 2007), and 40 health children were involved in the control group in the same period. TD group were subdivided into TD1 group (n=48) and TD2 group (n=32). TD1 group had episodic course and/or the history of upper respiratory infection with fever and sore throat prior to symptomatic attacks. Informed consent was obtained from all participants.

Results

The positive rate of serum anti-streptococcal antibody and anti-basal ganglia antibody in TD group were significantly higher than those in the control group(χ2=9.216, P<0.05; χ2=11.326, P<0.05). 51.4% of tic disorder children with positive anti-basal ganglia antibody had at least one positive anti-streptococcal antibody, which significantly higher than that in tic disorder children with negative anti-basal ganglia antibody (χ2=8.09, P<0.05). Meanwhile, the positive rate of serum anti-streptococcal antibody and anti-basal ganglia antibody in TD1 group were significantly higher than those in TD2 group(χ2=7.068, P<0.05; χ2=20.122, P<0.05). There were 9 patients in TD1 group consistent with the diagnostic criteria of pediatric autoimmune neuropsychiatric disorder with streptococcal infections.

Conclusion

①On the base of genetic predisposition, post-streptococcal autoimmune may be an environmental factor that can induce tic disorder. ② Pediatric autoimmune neuropsychiatric disorder with streptococcal infections may be one of the clinical groups of tic disorder.

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