Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2008, Vol. 04 ›› Issue (04): 321 -324. doi: 10.3760/cma.j.issn.1673-5250.2008.04.107

Original Article

Analysis of Phleboclysis of γ-Globulin Combined With Naloxone in 43 Encephalitis B Children Treatment

Ming-fang SHI, Miao CAI, Ying CHEN, Yong-bin LV, Xiao-min ZONG, Jie-mei YANG   

  1. Department of Pediatrics, the First People's Hospital of Yibin, Yibin 644000, China
  • Published:2008-08-01
Objective

To investigate the curative effect of intravenous infusion of γ-globulin combined with naloxone in the encephalitis B.

Methods

85 cases of children suffered of epidemic encephalitis B were divided into the therapeutic group(43 cases, odd number)and the control group(42 cases, even number)according to their hospitalization sequence from October 2005 to October 2007 in the Department of Pediatrics, the First People's Hospital of Yibin with the agreement of their guardians. The therapeutic group was treated with the routine comprehensive treatment(RCT)plus γ-globulin[400 mg/(kg•d), intravenous infusion, for 5 days]combined with naloxone[(0.01~0.02)mg/kg per time, 1~3 times per day,intravenous infusion, for 5~7 days], the control group was administered with the routine comprehensive treatment.

Results

The average time for pyretolysis, the convulsion and conscious disturbance in the therapeutic group was significant shorter than that of the control group with statistical significance(P<0. 01). And the incidence of respiratory failure in the therapeutic group was lower than that in the control group(P<0.05). In the follow-up with 6 months, the cure rate in the therapeutic group was significantly higher than that in the control group(P<0.01); the mortality and the incidence of sequelae(sustained neuro-psychiatric symptoms and abnormalities in the EEG or MRI)in the therapeutic group were strikingly lower than that in the control group(P<0.05).

Conclusion

Intravenous infusion of γ-globulin combined with naloxone in the encephalitis B can prevent the process of pars encephalica from getting worse. This therapeutic measure can also balance the function of central nervous system,regain palinesthesia efficiently, reduce the disability and enhance the cure rate. So it can be used as an effective way in the encephalitis B treatment.

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