Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2009, Vol. 05 ›› Issue (04): 393 -396. doi: 10.3877/cma.j.issn.1673-5250.2009.04.115

Original Article

Therapeutic Effects of Naloxone Combined With Aminofilina in the Treatment of Premature Infants Apnea

Xue-ni LIANG, Sheng-tao XIAO   

  1. Department of Pediatrics, Maternal and Child Health Hospital of Zigong (Women and children's Hospital of Zigong), Zigong 643000, Sichuan Province, China
  • Published:2009-08-01
Objective

To observe the therapeutic effects of naloxone combined with aminofilina in the treatment of premature infants apnea.

Methods

From January 2006 to December 2007, 86 cases who were diagnosed as premature infants apnea were randomly divided into observation group (n=46) and control group (n=40). Informed consent was obtained from all participates. Observation group injected naloxone at the dose of 0.1 mg/kg into veins at first, then received naloxone at the dose of 0.1 mg/kg mixed with 20 mL 10% glucose through intervenous drop infusion, twice per day. The first dose of 5 mg/kg for aminofilina mixed with (10~20)mL 10% glucose intravenous drop. Then the dose was reduced and maintained at the level of 2.5 mg/kg each time, twice per day. Treatment methods alternated for 3 days. Control group used aminofilina only, the application was the same as observation group. Therapeutic effects of two groups were compared.

Results

Effective rates of observation group and control group were 87% (40/46), and 67.5%(27/40), respectively. There had statistically significant difference between two groups(P<0.05).

Conclusion

Therapeutic effects of naloxone combination with aminofilina in the treatment of premature infants apnea surpasses aminofilina only.

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