Chinese Medical E-ournals Database

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2008, Vol. 04 ›› Issue (04): 311 -315. doi: 10.3760/cma.j.issn.1673-5250.2008.04.105

Original Article

Blood Sugar Management in Delivery for Pregnant Women With Abnormal Glucose Metabolism Associated With Neonatal Hypoglycemia

Yu-li ZHANG, Hui-xia YANG   

  1. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
  • Published:2008-08-01
Objective

To analyze the relationship between maternal blood glucose level and the incidence of neonatal hypoglycemia, and evaluate ways and significances of maternal blood glucose management of gestational diabetes mellitus(GDM)women during labor.

Methods

A retrospective analysis was conducted on 435 cases from August 2002 to October 2007 of singleton pregnancy with abnormal gestational glucose tolerance, whose blood glucose levels were monitored during labor, were subdivided into 206 cases with the gestational impaired glucose tolerance group(GIGT group),136 cases and 93 cases with the gestational diabetes mellitus Al(GDMA1 group)and A2 group(GDMA2 group), respectively.

Results

The morbidity of neonatal hypoglycemia in GIGT group, GDMAl group and GDMA2 group was 2.9%,2.9% and 1.1%,respectively(P=0.602). Within the 3 gestational groups of abnormal glucose metabolism, no significant difference was found in the incidence of neonatal hypoglycemia between women with the blood glucose<7.8 mmol/L and those with the blood glucose≥7.8 mmol/L occurring in labor without insulin treatment[the gestational impaired glucose tolerance group was 3% vs.1.3%;the gestational diabetes mellitus Al group was 0% vs.1.8%; the gestational diabetes mellitus A2 group was 0% vs. 0%(P>0.05)]. No correlation was detected between the immediate neonatal blood glucose value at birth and maternal mean blood glucose during labor in 3 groups(P=0. 260, 0.861,0.296).

Conclusion

With strict glycemia control for pregnant women and appropriate management of newborns, maternal hyperglycemia of the women with gestational diabetes mellitus during labor has limited effect on the level and the incidence of neonatal hypoglycemia. Blood glucose assay and immediate feed for high risk neonates might have more clinical importance.

1 Taylor R, Lee C,Kyne-Grzebalski D. Clinical outcomes of pregnancy in women with type 1 diabetes. Obstet Gynecol,2002,99(4):537-541.
2 Fan ZT, Yang HX, Gao XL, et al. Pregnancy outcomes in gestational diabetes. Inter J Gynecol Obstet, 2006,94:12-16.
3 Yang HX, Zhao Y.A controlled study for pregnant outcomes in women with abnormal gestational glucose tolerance. Chin Gen Pract, 2004,7:1044-1067.[杨慧霞,赵怿.妊娠期糖代谢异常对母儿结局影响的前瞻性对照研究.中国全科医学,2004,7:1044-1067.]
4 Vannucci RC, Vannucci SJ. Hypoglycemia brain injury. Semin Neonatol, 2001,6:147-149.
5 Li H, Zhu ZL. Progress of neonatal hypoglycemia. Foreign Med Sci: Sect Matern Child Health, 2002,11(3):112-114.[李晖,朱忠良.新生儿血糖异常进展.国外医学妇幼保健分册,2002,11(3):112-114.]
6 Jovanovic L.Achieving euglycaemia in women with gestational diabetes mellitus: Current options for screening,diagnosis and treatment. Drugs,2004, 64(13):1401-1417.
7 Srinivasan G,Pildes RD,Cattamanchi G,et al. Clinical and laboratory observations.J Pediatr,1986,109:114-117.
8 Langer O, Yogev Y, Most O. Gststional diabetes: The consequences of not treating. Am J Obstet Gynecol, 2005,192(4):989-997.
9 Sun WJ, Yang HX. Maternal and fetal outcomes in pregnant women with abnormal glucose metabolism. Chin J Obstet Gynecol, 2007,6(42):377-381.[孙伟杰,杨慧霞.妊娠合并糖代谢异常孕妇的妊娠结局分析.中华妇产科杂志,2007, 6(42):377-381.]
10 Buchanan TA, Xiang AH. Gestational diabetes mellitus.J Clin Invest,2005,115(3):485-491.
11 Shan D, Yang HX, Han XM, et al. Study on controlling the blood glucose level of gestational diabetes mellitus sufferer regularly during labor. Chin J Obstet Gynecol, 2003, 38(11):673-675.[山丹,杨慧霞,韩小妹等.妊娠合并糖代谢异常孕妇产程中血糖监测的前瞻性研究.中华妇产科杂志,2003, 38(11):673-675.]
[1] Lin Lin, Simeng Tian, Yonghua Yu, Feifei Xu, Mingli Huang. Current research status on treatment of intrauterine adhesion by stem cells and their exosomes[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(03): 271-275.
[2] Qian Li, Qian Liu, Hailing Zhu, Juan Ni, Baoqin Ren, Changyun Liu. Efficacy of recombinant human growth hormone therapy in children with idiopathic short stature[J]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2024, 20(03): 346-352.
[3] Yan Meng, Rubing Tang, Yi Jiang, Hua Lu, Yulan Su, Qiong Zhang, Yingyu He. Application of preventive lymphaticovenular anastomosis in breast cancer patients with axillary lymph node dissection based on multidisciplinary collabration[J]. Chinese Journal of Injury Repair and Wound Healing(Electronic Edition), 2024, 19(03): 204-207.
[4] Jia Dong, Kun Wang, Li Zhang. Prognostic nutritional index combined with immunoglobulin,fasting blood glucose level and serum alpha-fetoprotein in predicting poor prognosis in patients with HBV associated chronic acute liver failure after treatment[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(06): 555-559.
[5] Qiuzi Cui, Hongman Yao, Yingchun Ai. Analysis of the predictive value of monitoring NLR, PLR, CAR, albumin, serum calcium and blood glucose levels in acute kidney injury in patients with acute pancreatitis[J]. Chinese Journal of Digestion and Medical Imageology(Electronic Edition), 2024, 14(03): 244-248.
[6] Xiaoyan Wang, Liping Zhu, Shunyu Hou, Yongfei Yue. The impact of intraspinal analgesia on vaginal delivery in pregnant women with Group B hemolytic streptococcus[J]. Chinese Journal of Obstetric Emergency(Electronic Edition), 2024, 13(02): 112-116.
[7] Yuan Mao, Yuzhuo Wang, Juan Gao, Lincui Bian, Zheng Yuan, Zhiqiang Li, Mingliang Zhang. Exploration of lean management practice in independent clinical laboratory[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(04): 193-198.
[8] Zongyong Wu, Xiaoyu Zhang, Junjie Wan, Yiteng Lin, Li Zhang, Jun Qi, Yongping Lin. Quality control of laboratory specimens sent to the third-party medical laboratories[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(04): 199-203.
[9] Wenying Luo, Lihong Qiu, Hui Liu, Jiaze Dai. Practical study of problem-based learning teaching model in labor education of “quality control before examination and analysis”[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(04): 244-250.
[10] Yuwei Di, Yanfei Luo, Chenglong Lin, Ying Luo, Zhengkang Li, Huaxin Mai, Bing Gu. Innovative application of excellent worker interviews and speech contests into the cognitive teaching of job competency for clinical laboratory science students[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(03): 140-144.
[11] Chunmin Lu, Yasha Luo, Yuan Chen, Xianhua Zheng, Ru Bai, Mingyong Luo. Evaluation of teaching effect of clinical communication competence course based on outcome based education concept[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(03): 145-149.
[12] Sicong Chen, Tao Zhang. Application of case analysis combined with mini-clinical evaluation exercise scale in clinical biochemical laboratory technology teaching[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(03): 150-154.
[13] Wanjun Chen, Yueting Gao, Jinlong Song. Report and analysis of a case of POEMS syndrome[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(03): 179-183.
[14] Jing Zheng, Hong Zhang, Li Wan, Pinjia Wang, Nianhua Deng, Qinglian Zhang. Practice and exploration of "five elements" curriculum ideological and political for application-oriented talents of medical laboratory[J]. Chinese Journal of Clinical Laboratory Management(Electronic Edition), 2024, 12(02): 122-127.
[15] Changen Liu, Yan Li, Qide Zhang. Analysis of clinical characteristics of autoimmune gastritis detected by endoscopic screening[J]. Chinese Journal of Gastrointestinal Endoscopy(Electronic Edition), 2024, 11(04): 233-237.
Viewed
Full text


Abstract