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中华妇幼临床医学杂志(电子版)

Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition) ›› 2023, Vol. 19 ›› Issue (03): 273 -277. doi: 10.3877/cma.j.issn.1673-5250.2023.03.005

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Current research status in diagnosis and treatment of children with Mycoplasma pneumoniae pneumonia

Juan Shen, Yu Chen†(), Yufeng Shen, Pei Zhang   

  1. Department of Pediatrics, Shanghai Fourth People′s Hospital Affiliated to Tongji University, Shanghai 200434, China
  • Received:2022-12-27 Revised:2023-04-03 Published:2023-06-01
  • Corresponding author: Yu Chen
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Mycoplasma pneumoniae (MP) is one of the common pathogens of Mycoplasma pneumoniae pneumonia (MPP) in children. The diagnosis of children with MPP should be based on clinical symptoms, imaging and laboratory tests. With the incidence of severe MPP (SMPP) and macrolide-resistant MPP increasing year by year, the clinical symptoms of those children are severe, often complicated with systemic symptoms and organ damage, and the treatment is difficult. This article reviews the latest research progress of epidemiologic feature, clinical manifestation, imaging and laboratory examination characteristics and treatment of MPP.

Key words: Mycoplasma pneumoniae, Pneumonia, Mycoplasma, Imaging, Laboratory testing, Treatment, Child
[1]
Chang CH, Tsai CK, Tsai TA, et al. Epidemiology, and clinical manifestations of children with macrolide-resistant Mycoplasma pneumoniae pneumonia in Southern Taiwan[J]. Pediatr Neonatol, 2021, 62(5): 536-542. DOI: 10.1016/j.pedneo.2021.05.017.
[2]
Krafft C, Christy C. Mycoplasma pneumonia in children and adolescents[J]. Pediatr Rev, 2020, 41(1): 12-19. DOI: 10.1542/pir.2018-0016.
[3]
Wang X, Li M, Luo M, et al. Mycoplasma pneumoniae triggers pneumonia epidemic in autumn and winter in Beijing: a multicentre, population-based epidemiological study between 2015 and 2020[J]. Emerg Microbes Infect, 2022, 11(1): 1508-1517. DOI: 10.1080/22221751.2022.2078228.
[4]
张敏. 儿童重症肺炎支原体肺炎的临床特点及影像学表现分析[J]. 中国CT和MRI杂志，2020, 18(2): 37-40. DOI: 10.3969/j.issn.1672-5131.2020.02.012.
[5]
Li F, Zhang Y, Shi P, et al. Mycoplasma pneumoniae and adenovirus coinfection cause pediatric severe community-acquired pneumonia[J]. Microbiol Spectr, 2022, 10(2): e0002622. DOI: 10.1128/spectrum.00026-22.
[6]
王雷，丰小希，陆振. 小儿肺炎支原体肺炎及肺外并发症的临床研究[J]. 深圳中西医结合杂志，2020, 30(2): 87-89. DOI: 10.16458/j.cnki.1007-0893.2020.02.043.
[7]
Sheng CQ, Yang CF, Ao Y, et al. Mycoplasma pneumoniae pneumonia with pulmonary embolism: a study on pediatric cases in Jilin province of China[J]. Exp Ther Med, 2021, 21(3): 201. DOI: 10.3892/etm.2021.9634.
[8]
Han C, Zhang T, Zheng J, et al. Analysis of the risk factors and clinical features of Mycoplasma pneumoniae pneumonia with embolism in children: a retrospective study[J]. Ital J Pediatr, 2022, 48(1): 153. DOI: 10.1186/s13052-022-01344-0.
[9]
刘胜，范承武. CT诊断重症肺炎支原体肺炎的价值[J]. 中国医学物理学杂志，2021, 38(7): 842-845. DOI: 10.3969/j.issn.1005-202X.2021.07.010.
[10]
Leng J, Yang Z, Wang W. Diagnosis and prognostic analysis of Mycoplasma pneumoniae pneumonia in children based on high-resolution computed tomography[J]. Contrast Media Mol Imaging, 2022, 1985531. DOI: 10.1155/2022/1985531.
[11]
Wang X, Lin X. Analysis of clinical related factors of severe Mycoplasma pneumoniae pneumonia in children based on imaging diagnosis[J]. Comput Math Methods Med, 2022, 4852131. DOI: 10.1155/2022/4852131.
[12]
杨洁，付红敏，王凡，等. 儿童重症肺炎支原体肺炎的CT影像学特点分析[J]. 实用临床医药杂志，2021, 25(1): 66-68, 73. DOI: 10.7619/jcmp.20200303.
[13]
赵志勇，郑昊宇，张巍. 细菌性、病毒性及支原体肺炎的高分辨率CT征象分析与鉴别[J]．武警医学，2020, 31(9): 774-777. DOI: 10.14010/j.cnki.wjyx.2020.09.010.
[14]
Li H, Li T, Cai Q, et al. Development and validation of a radiomics nomogram for differentiating Mycoplasma pneumonia and bacterial pneumonia[J]. Diagnostics (Basel), 2021, 11(8): 1330. DOI: 10.3390/diagnostics11081330.
[15]
Chen X, Li W, Wang F, et al. Early recognition of necrotizing pneumonia in children based on non-contrast-enhanced computed tomography radiomics signatures[J]. Transl Pediatr, 2021, 10(6): 1542-1551. DOI: 10.21037/tp-20-241.
[16]
Li S, Jiang W, Huang J, et al. Highly sensitive and specific diagnosis of COVID-19 by reverse transcription multiple cross-displacement amplification-labelled nanoparticles biosensor[J]. Eur Respir J, 2020, 56(6): 2002060. DOI: 10.1183/13993003.02060-2020.
[17]
Li J, Sun L, Wu X, et al. Early diagnosis of Mycoplasma pneumoniae in children: simultaneous amplification and testing (SAT) is the key[J]. Front Pediatr, 2019, 7: 441. DOI: 10.3389/fped.2019.00441.
[18]
Dai FF, Liu FQ, Chen X, et al. The treatment of macrolide-resistant Mycoplasma pneumoniae pneumonia in children[J]. J Clin Pharm Ther, 2021, 46(3): 705-710. DOI: 10.1111/jcpt.13331.
[19]
Ahn JG, Cho HK, Li D, et al. Efficacy of tetracyclines and fluoroquinolones for the treatment of macrolide-refractory Mycoplasma pneumoniae pneumonia in children: a systematic review and Meta-analysis[J]. BMC Infect Dis, 2021, 21(1): 1003. DOI: 10.1186/s12879-021-06508-7.
[20]
Shen HX, Liu C, Lin HJ, et al. The efficacy and safety of minocycline as adjuvant therapy in refractory mycoplasma pneumonia in Chinese children: a Meta-analysis[J]. Ital J Pediatr, 2022, 48(1): 176. DOI: 10.1186/s13052-022-01362-y.
[21]
Sun LL, Ye C, Zhou YL, et al. Meta-analysis of the clinical efficacy and safety of high- and low-dose methylprednisolone in the treatment of children with severe Mycoplasma pneumoniae pneumonia[J]. Pediatr Infect Dis J, 2020, 39(3): 177-183. DOI: 10.1097/INF.0000000000002529.
[22]
孙建华，赵雨芳，叶君红. 糖皮质激素辅助治疗儿童重症肺炎支原体肺炎的临床研究[J]．中国临床药理学杂志，2021, 37(7): 795-797, 801. DOI: 10.13699/j.cnki.1001-6821.2021.07.001.
[23]
Chen N, Li M. Case report and literature review: clinical characteristics of 10 children with Mycoplasma pneumoniae-induced rash and mucositis[J]. Front Pediatr, 2022, 10: 823376. DOI: 10.3389/fped.2022.823376.
[24]
Daba M, Kang PB, Sladky J, et al. Intravenous immunoglobulin as a therapeutic option for Mycoplasma pneumoniae encephalitis[J]. J Child Neurol, 2019, 34(11): 687-691. DOI: 10.1177/0883073819854854.
[25]
卢保霞，陈荣寿，汪珊，等. 纤维支气管镜下肺泡灌洗治疗小儿肺炎支原体大叶性肺炎的临床疗效分析[J]. 中华全科医学，2021, 19(7): 1138-1141. DOI: 10.16766/j.cnki.issn.1674-4152.002005.
[26]
Jiang Z, Li S, Zhu C, et al. Mycoplasma pneumoniae infections: pathogenesis and vaccine development. pathogens[J]. Pathogens, 2021, 10(2): 119. DOI: 10.3390/pathogens10020119.
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