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中华妇幼临床医学杂志(电子版) ›› 2026, Vol. 22 ›› Issue (02) : 103 -108. doi: 10.3877/cma.j.issn.1673-5250.2026.02.002

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孕妇低剂量抗菌药物应用对新生儿肠道菌群影响的研究现状
冉金玲1,2, 冯卓慧3, 赵智2,()   
  1. 1西安医学院研究生院,西安 710021
    2陕西省人民医院新生儿科,西安 710068
    3西藏民族大学医学院,咸阳 712082
  • 收稿日期:2025-11-22 修回日期:2026-03-01 出版日期:2026-04-01
  • 通信作者: 赵智

Current research status on effects of applying low-dose antibiotics during pregnancy on intestinal flora in neonates

Jinling Ran1,2, Zhuohui Feng3, Zhi Zhao2,()   

  1. 1Graduate School, Xi′an Medical University, Xi′an 710021, Shaanxi Province, China
    2Department of Neonatology, Shaanxi Provincial People′s Hospital, Xi′an 710068, Shaanxi Province, China
    3School of Medicine, Xizang Minzu University, Xianyang 712082, Shaanxi Province, China
  • Received:2025-11-22 Revised:2026-03-01 Published:2026-04-01
  • Corresponding author: Zhi Zhao
  • Supported by:
    Top-notch Talent Project of Science and Technology Talents, Shaanxi Provincial People′s Hospital(2022BJ-10); Reserve Academic Leader Development Program of Shaanxi Provincial People′s Hospital(2025)
引用本文:

冉金玲, 冯卓慧, 赵智. 孕妇低剂量抗菌药物应用对新生儿肠道菌群影响的研究现状[J/OL]. 中华妇幼临床医学杂志(电子版), 2026, 22(02): 103-108.

Jinling Ran, Zhuohui Feng, Zhi Zhao. Current research status on effects of applying low-dose antibiotics during pregnancy on intestinal flora in neonates[J/OL]. Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition), 2026, 22(02): 103-108.

随着抗菌药物在医疗领域的广泛应用,其治疗感染性疾病的同时,潜在不良反应对人类健康的影响亦日益受到关注。孕期作为女性的一个特殊生理阶段,抗菌药物的使用不仅对孕妇产生影响,还可能对其子代包括胎儿及新生儿产生累积效应,特别是影响新生儿正常肠道菌群的建立,并与菌群代谢稳态、抗菌药物抗性基因(ARG)表达相关,从而可能导致新生儿相关疾病,甚至与婴幼儿期发生变态反应疾病、肥胖症等相关。笔者拟系统阐述孕妇抗菌药物应用现状,重点阐述孕期抗菌药物暴露对新生儿肠道菌群定植的影响及其潜在作用机制的最新研究现状,旨在为临床合理用药及保护子代健康提供理论依据。

Given widespread use of antibiotics in medicine, concerns are growing about their potential adverse reactions on human health when used to treat infectious diseases. During pregnancy, a special physiological stage, the use of antibiotics affects not only the pregnant woman, but also has a cumulative effect on the neonate. This can affect the establishment of normal intestinal flora in the neonate, as well as the metabolic homeostasis and expression of antimicrobial resistance gene (ARG). This may lead to diseases in the neonate, as well as allergies and obesity in infancy and childhood. This article aims to systematically elucidate the current status of antimicrobial use in pregnant women, specifically focus on the latest research regarding the impact of prenatal antimicrobial exposure on neonatal intestinal microbiota colonization and the underlying mechanisms involved, with the objective of providing a theoretical basis for rational clinical drug use and the health protection of offspring.

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